Summary

Name CASP8
Full Name Caspase-8
Synonyms CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH | MCH5
Primary ID Q14790
Links - -
Type protein
Relations 33
Pathways Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF alpha, Alzheimer Disease
Function Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png cleavage RIPK1 0.6
Publications: 1 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF alpha
+ up-regulates activity img/direct-activation.png cleavage BID 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF alpha
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:TNF alpha
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png dephosphorylation CASP8 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CASP8 0.81
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF alpha
+ up-regulates activity img/direct-activation.png binding CASP8 0.76
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF alpha
+ up-regulates activity img/direct-activation.png binding CASP8 0.49
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF alpha
+ form complex img/form-complex.png binding Caspase 8 complex 0.14
Publications: 1
+ up-regulates activity img/indirect-activation.png CASP9 0.36
Publications: 1 Organism: In Vitro
Pathways:Death Receptor Signaling, Mitochondrial Control of Apoptosis
+ up-regulates activity img/direct-activation.png cleavage CASP3 0.49
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Alzheimer Disease, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF alpha
+ up-regulates img/direct-activation.png cleavage CASP8 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CASP8 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage CASP6 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell death 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CASP8AP2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CYCS 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Death Receptor Signaling, Mitochondrial Control of Apoptosis
+ up-regulates img/direct-activation.png cleavage CASP8 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage CASP7 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CASP8 0.66
Publications: 2 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Heart, Lymphoid Tissue
Pathways:Death Receptor Signaling
+ down-regulates img/direct_inhibition.png binding CASP8 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.52
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF alpha