| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | CASP8 | Ser305 | IYQLMDHsNMDCFIC | phosphorylation down-regulates quantity by destabilization | 24484936 | SIGNOR-272989 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | CASP8 PSer305 | phosphorylation down-regulates ⊣ | CASP8 | 24484936 | SIGNOR-272989 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation down-regulates quantity by destabilization | CASP8 | SIGNOR-272989 |
