| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 24342355 | SIGNOR-244509 |
| CyclinB/CDK1 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 20937773 | SIGNOR-216737 |
| CDK1 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 20937773 | SIGNOR-168446 |
| MAPK3 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 24342355 | SIGNOR-203480 |
| MAPK1 | CASP8 | Ser387 | YLEMDLSsPQTRYIP | phosphorylation down-regulates | 24342355 | SIGNOR-203473 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERK1/2 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 24342355 | SIGNOR-244509 |
| CyclinB/CDK1 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 20937773 | SIGNOR-216737 |
| CDK1 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 20937773 | SIGNOR-168446 |
| MAPK3 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 24342355 | SIGNOR-203480 |
| MAPK1 | phosphorylation up-regulates → | CASP8 PSer387 | phosphorylation down-regulates ⊣ | CASP8 | 24342355 | SIGNOR-203473 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ERK1/2 | phosphorylation down-regulates | CASP8 | SIGNOR-244509 |
| CyclinB/CDK1 | phosphorylation down-regulates | CASP8 | SIGNOR-216737 |
| CDK1 | phosphorylation down-regulates | CASP8 | SIGNOR-168446 |
| MAPK3 | phosphorylation down-regulates | CASP8 | SIGNOR-203480 |
| MAPK1 | phosphorylation down-regulates | CASP8 | SIGNOR-203473 |
