Entity Details

Name PTPN6_Tyr448
ID Q14790
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
LYNCASP8Tyr448TILTEVNyEVSNKDDphosphorylation
down-regulates activity		18086677SIGNOR-272980
PTPN6CASP8Tyr448TILTEVNyEVSNKDDdephosphorylation
up-regulates activity		18086677SIGNOR-248478
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
LYNphosphorylation
up-regulates
→
CASP8
PTyr448		phosphorylation
down-regulates
⊣		CASP818086677SIGNOR-272980
PTPN6dephosphorylation
down-regulates
⊣
CASP8
PTyr448		dephosphorylation
down-regulates
⊣		CASP818086677SIGNOR-248478
Regulator Mechanism/Effect Target SIGNOR-ID
LYNphosphorylation
→
down-regulates activity 		CASP8SIGNOR-272980
PTPN6dephosphorylation
→
up-regulates activity 		CASP8SIGNOR-248478