| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | CASP8 | Tyr380 | TDSEEQPyLEMDLSS | phosphorylation down-regulates | 16619028 | SIGNOR-146127 |
| PTPN6 | CASP8 | Tyr380 | TDSEEQPyLEMDLSS | dephosphorylation up-regulates activity | 18086677 | SIGNOR-248477 |
| LYN | CASP8 | Tyr380 | TDSEEQPyLEMDLSS | phosphorylation down-regulates activity | 18086677 | SIGNOR-272979 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | CASP8 PTyr380 | phosphorylation down-regulates ⊣ | CASP8 | 16619028 | SIGNOR-146127 |
| PTPN6 | dephosphorylation down-regulates ⊣ | CASP8 PTyr380 | dephosphorylation down-regulates ⊣ | CASP8 | 18086677 | SIGNOR-248477 |
| LYN | phosphorylation up-regulates → | CASP8 PTyr380 | phosphorylation down-regulates ⊣ | CASP8 | 18086677 | SIGNOR-272979 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation down-regulates | CASP8 | SIGNOR-146127 |
| PTPN6 | dephosphorylation → up-regulates activity | CASP8 | SIGNOR-248477 |
| LYN | phosphorylation → down-regulates activity | CASP8 | SIGNOR-272979 |
