| Name | MEF2D |
| ID | Q14814 |
| Role | substrate |
| Enzymatic Domains |
MADS-box 3-57 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | MEF2D | Ser251 | NKVIPAKsPPPPTHS | phosphorylation down-regulates activity | 34109727 | SIGNOR-277901 |
| MAPK14 | MEF2D | – | phosphorylation up-regulates activity | 18026121 | SIGNOR-159331 | |
| CyclinD/CDK4 | MEF2D | Ser110 | GEDSLEQsPLLEDKY | phosphorylation down-regulates quantity by destabilization | 25733682 | SIGNOR-276888 |
| DYRK1A | MEF2D | Ser251 | NKVIPAKsPPPPTHS | phosphorylation down-regulates activity | 34109727 | SIGNOR-277565 |
| MAPK14 | MEF2D | – | phosphorylation up-regulates activity | 21902831 | SIGNOR-176554 | |
| CDK5 | MEF2D | Ser444 | SIKSEPVsPSRERSP | phosphorylation down-regulates activity | 19812325 | SIGNOR-279509 |
| CyclinD/CDK4 | MEF2D | Ser98 | KGFNGCDsPEPDGED | phosphorylation down-regulates quantity by destabilization | 25733682 | SIGNOR-276887 |
| MAPK7 | MEF2D | Ser180 | LTDPRLLsPQQPALQ | phosphorylation up-regulates | 10849446 | SIGNOR-236041 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| DYRK1A | phosphorylation up-regulates → | MEF2D PSer251 | phosphorylation down-regulates ⊣ | MEF2D | 34109727 | SIGNOR-277901 |
| CyclinD/CDK4 | phosphorylation up-regulates → | MEF2D PSer110 | phosphorylation down-regulates ⊣ | MEF2D | 25733682 | SIGNOR-276888 |
| DYRK1A | phosphorylation up-regulates → | MEF2D PSer251 | phosphorylation down-regulates ⊣ | MEF2D | 34109727 | SIGNOR-277565 |
| CDK5 | phosphorylation up-regulates → | MEF2D PSer444 | phosphorylation down-regulates ⊣ | MEF2D | 19812325 | SIGNOR-279509 |
| CyclinD/CDK4 | phosphorylation up-regulates → | MEF2D PSer98 | phosphorylation down-regulates ⊣ | MEF2D | 25733682 | SIGNOR-276887 |
| MAPK7 | phosphorylation up-regulates → | MEF2D PSer180 | phosphorylation up-regulates → | MEF2D | 10849446 | SIGNOR-236041 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| DYRK1A | phosphorylation → down-regulates activity | MEF2D | SIGNOR-277901 |
| MAPK14 | phosphorylation → up-regulates activity | MEF2D | SIGNOR-159331 |
| CyclinD/CDK4 | phosphorylation down-regulates quantity by destabilization | MEF2D | SIGNOR-276888 |
| DYRK1A | phosphorylation → down-regulates activity | MEF2D | SIGNOR-277565 |
| MAPK14 | phosphorylation → up-regulates activity | MEF2D | SIGNOR-176554 |
| CDK5 | phosphorylation → down-regulates activity | MEF2D | SIGNOR-279509 |
| CyclinD/CDK4 | phosphorylation down-regulates quantity by destabilization | MEF2D | SIGNOR-276887 |
| MAPK7 | phosphorylation → up-regulates | MEF2D | SIGNOR-236041 |