Summary

Name MEF2D
Full Name Myocyte-specific enhancer factor 2D
Synonyms MEF2D_HUMAN
Primary ID Q14814
Links - -
Type protein
Relations 22
Pathways IGF and Myogenesis, P38 Signaling and Myogenesis
Function Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation MEF2D 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MEF2D 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png binding MEF2D 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/indirect-activation.png MEF2D 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:IGF and Myogenesis, P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH7 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png MEF2D 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Myotube
+ up-regulates img/indirect-activation.png MEF2D 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/indirect_inhibition.png MEF2D 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MEF2D 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ down-regulates img/direct_inhibition.png binding MEF2D 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/indirect-activation.png ASH2L 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding MEF2D 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation DES 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding MEF2D 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYF6 0.14
Publications: 1 Organism: Mus Musculus
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation MEF2D 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH1 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH10 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MYH2 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ form complex img/form-complex.png binding Myog/SWI/SNF complex 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ down-regulates img/direct_inhibition.png binding MEF2D 0.14
Publications: 1 Organism: Homo Sapiens