| + |
CyclinD/CDK4 | down-regulates quantity by destabilization 
phosphorylation
|
MEF2D |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276888 |
Ser110 |
GEDSLEQsPLLEDKY |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 25733682 |
MEF2C and MEF2D interact with the E3 ligase F-box protein SKP2, which mediates their subsequent degradation through the ubiquitin-proteasome system. The cyclin-dependent kinase 4 (CDK4)/cyclin D1 complex phosphorylates MEF2D on serine residues 98 and 110, and phosphorylation of these residues is an important determinant for SKP2 binding. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276887 |
Ser98 |
KGFNGCDsPEPDGED |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 25733682 |
MEF2C and MEF2D interact with the E3 ligase F-box protein SKP2, which mediates their subsequent degradation through the ubiquitin-proteasome system. The cyclin-dependent kinase 4 (CDK4)/cyclin D1 complex phosphorylates MEF2D on serine residues 98 and 110, and phosphorylation of these residues is an important determinant for SKP2 binding. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| Pathways: | IGF and Myogenesis |
| + |
MAPK7 | up-regulates 
phosphorylation
|
MEF2D |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236041 |
Ser180 |
LTDPRLLsPQQPALQ |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10849446 |
Here, we demonstrate that, in addition to mef2c, bmk1 phosphorylates and activates mef2a and mef2d but not mef2b. the sites phosphorylated by activated bmk1 were mapped to ser-355, thr-312, and thr-319 of mef2a and ser-179 of mef2d both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | down-regulates activity
phosphorylation
|
MEF2D |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277565 |
Ser251 |
NKVIPAKsPPPPTHS |
in vitro |
|
| pmid |
sentence |
| 34109727 |
Here, we uncovered that dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A), a kinase critical in Down's syndrome pathogenesis, directly bound to and phosphorylated MEF2D at Ser251 in vitro. Phosphorylation of MEF2D by DYRK1A significantly increased MEF2D protein level but attenuated its transcriptional activity, which resulted in decreased transcriptions of MEF2D target genes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277901 |
Ser251 |
NKVIPAKsPPPPTHS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 34109727 |
DYRK1A phosphorylates MEF2D and decreases its transcriptional activity |
|
| Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
| + |
CDK5 | down-regulates activity
phosphorylation
|
MEF2D |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279509 |
Ser444 |
SIKSEPVsPSRERSP |
Homo sapiens |
|
| pmid |
sentence |
| 19812325 |
In this case, cdk5 phosphorylates MEF2D on Ser444 suppressing its transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2D | up-regulates quantity by expression
transcriptional regulation
|
MYH10 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238766 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15728583 |
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
HDAC5 | down-regulates
binding
|
MEF2D |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84029 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11062529 |
The histone deacetylase hdac-5, upon dephosphorylation and translocation to the nucleus, directly inactivates mef2, preventing myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
MEF2D | up-regulates quantity by expression
transcriptional regulation
|
MYH1 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238751 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15728583 |
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
MEF2D | up-regulates quantity by expression 
transcriptional regulation
|
MYH7 |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251957 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 17111365 |
Transient transfection assays demonstrated that the calcineurin/NFATc1 signaling pathway is essential for MyHCbeta promoter activation during transformation of C2C12 myotubes but is not sufficient for complete fast MyHCIId/x promoter inhibition. Along with NFATc1, myocyte enhancer factor-2D (MEF-2D) and the myogenic transcription factor MyoD transactivated the MyHCbeta promoter in calcium-ionophore-treated myotubes in a calcineurin-dependent manner. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MEF2D | up-regulates quantity by expression
transcriptional regulation
|
MYH2 |
0.322 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238712 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15728583 |
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive transcription factors, the serum response factor, Oct-1, and myocyte enhancer factor-2, whereas the other two genes (IIa and IId/x) have nucleotide substitutions in these sites that reduce binding and transcriptional activation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | IGF and Myogenesis |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MEF2D |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159331 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18026121 |
Targeting of ash2l to specific genes is mediated by the transcriptional regulator mef2d. Furthermore, this interaction is modulated during differentiation through activation of the p38 mapk signaling pathway via phosphorylation of mef2d. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176554 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Through phosphorylation of mef2d, p38 recruits an ash2l-containing complex to myogenic loci during differentiation, which results in the marking of these genes for expression. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MEF2D | form complex 
binding
|
Myog/SWI/SNF complex |
0.666 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151679 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17194702 |
Upon the expression of myogenin, myogenin, mef2d, and brg1 localize to the myogenin promoter to maintain myogenin expression./ Swi/snf chromatin-remodeling activity is required for myogenin expression in differentiated skeletal muscle |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| + |
MEF2D | up-regulates
|
ASH2L |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159334 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18026121 |
Targeting of ash2l to specific genes is mediated by the transcriptional regulator mef2d. Furthermore, this interaction is modulated during differentiation through activation of the p38 mapk signaling pathway via phosphorylation of mef2d. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
NFATC2 | up-regulates
binding
|
MEF2D |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-117589 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11796223 |
Upon dephosphorylation by calcineurin, nfatc2, also referred to as nfatp/nfat1, translocates to the nucleus where it directly associates with mef2a and -d. Nfatc2 stimulates mef2-dependent transcription by facilitating recruitment of the p300 coactivator to mef2-response elements. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
AKT | up-regulates
|
MEF2D |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244303 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10896679 |
Two candidates that may function as mediators of pi3-k in the phosphorylation of mef2 proteins are pkb and big map kinase 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
SCF-SKP2 | down-regulates quantity by destabilization
ubiquitination
|
MEF2D |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276889 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 25733682 |
MEF2C and MEF2D interact with the E3 ligase F-box protein SKP2, which mediates their subsequent degradation through the ubiquitin-proteasome system. The cyclin-dependent kinase 4 (CDK4)/cyclin D1 complex phosphorylates MEF2D on serine residues 98 and 110, and phosphorylation of these residues is an important determinant for SKP2 binding. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CyclinD/CDK4 | down-regulates
binding
|
MEF2D |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216966 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
In contrast to cdk2, cyclin d/cdk4 blocks myod activity through an as yet unclear mechanism that may involve direct binding. Cyclin d/cdk4 can also block the activity of myogenin and all mef2 isoforms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
CDK4 | down-regulates
binding
|
MEF2D |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176524 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
In contrast to cdk2, cyclin d/cdk4 blocks myod activity through an as yet unclear mechanism that may involve direct binding. Cyclin d/cdk4 can also block the activity of myogenin and all mef2 isoforms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2D | up-regulates quantity by expression
transcriptional regulation
|
MYF6 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238715 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 7739551 |
Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | IGF and Myogenesis |
| + |
EP300 | up-regulates
binding
|
MEF2D |
0.751 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232162 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11796223 |
Once released from associated repressors, MEF2 is bound by the p300 coactivator, which possesses histone acetyltransferase activity. Thus, the net result of CaMK signaling to MEF2 complexes is increased histone acetylation (Ac), which relaxes chromatin and stimulates MEF2 target gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
YWHAQ | up-regulates
binding
|
MEF2D |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11433030 |
14-3-3tau associates with and activates the mef2d transcription factor during muscle cell differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HDAC4 | down-regulates
binding
|
MEF2D |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-76237 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10737771 |
We discovered that mef2 interacts with histone deacetylases (hdacs) 4 and 5, resulting in repression of the transcriptional activity of mef2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IGF and Myogenesis |
| + |
CABIN1 | down-regulates 
|
MEF2D |
0.803 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17172641 |
Thus, cabin1 recruits chromatin-modifying enzymes, both histone deacetylases and a histone methyltransferase, to repress mef2 transcriptional activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | down-regulates
|
MEF2D |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235602 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14739161 |
Tgf-beta was shown to inhibit myogenin and mef2d expression and myotube formation in c2c12. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
AKT1 | up-regulates
|
MEF2D |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79338 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 10896679 |
Two candidates that may function as mediators of pi3-k in the phosphorylation of mef2 proteins are pkb and big map kinase 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | IGF and Myogenesis, P38 Signaling and Myogenesis |
| + |
MEF2D | up-regulates quantity by expression
transcriptional regulation
|
DES |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241504 |
|
|
Mus musculus |
Myoblast |
| pmid |
sentence |
| 25653159 |
Ectopic expression of myogenin and a specific Mef2 isoform induced myogenic differentiation without activating endogenous MyoD expression. Under these conditions, the regulatory sequences of late gene loci were not in close proximity, and these genes were prematurely activated. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
MEF2D
- 
- 