| Name | NFATC4 |
| ID | Q14934 |
| Role | substrate |
| Enzymatic Domains |
RHD 401-582 PROSITE-ProRule
IPT/TIG 586-683 |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| p38 | NFATC4 | Ser170 | GGAFFSPsPGSSSLS | phosphorylation down-regulates | 11997522 | SIGNOR-87397 |
| MAPK8 | NFATC4 | Ser213 | ASRFGLGsPLPSPRA | phosphorylation up-regulates activity | 17875713 | SIGNOR-280032 |
| MAPK8 | NFATC4 | Ser217 | GLGSPLPsPRASPRP | phosphorylation up-regulates activity | 17875713 | SIGNOR-280033 |
| MAPK9 | NFATC4 | Ser213 | ASRFGLGsPLPSPRA | phosphorylation up-regulates activity | 17875713 | SIGNOR-280035 |
| MAPK9 | NFATC4 | Ser217 | GLGSPLPsPRASPRP | phosphorylation up-regulates activity | 17875713 | SIGNOR-280036 |
| RPS6KA3 | NFATC4 | Ser289 | PALSRRGsLGEEGSE | phosphorylation up-regulates | 17213202 | SIGNOR-234473 |
| RPS6KA3 | NFATC4 | Ser281 | SGTPSSAsPALSRRG | phosphorylation up-regulates | 17213202 | SIGNOR-234465 |
| MAPK3 | NFATC4 | Ser676 | SNGRRKRsPTQSFRF | phosphorylation up-regulates | 15657420 | SIGNOR-133276 |
| RPS6KA3 | NFATC4 | Ser676 | SNGRRKRsPTQSFRF | phosphorylation up-regulates | 15657420 | SIGNOR-133283 |
| ERK1/2 | NFATC4 | – | phosphorylation up-regulates | 15657420 | SIGNOR-270160 | |
| RPS6KA3 | NFATC4 | Ser344 | QAVALPRsEEPASCN | phosphorylation up-regulates | 17213202 | SIGNOR-235652 |
| MAPK14 | NFATC4 | Ser170 | GGAFFSPsPGSSSLS | phosphorylation down-regulates activity | 11997522 | SIGNOR-250108 |
| MAPK14 | NFATC4 | Ser168 | QGGGAFFsPSPGSSS | phosphorylation down-regulates activity | 11997522 | SIGNOR-250107 |
| Gbeta | NFATC4 | – | phosphorylation up-regulates | 15657420 | SIGNOR-270047 | |
| RPS6KA3 | NFATC4 | Ser285 | SSASPALsRRGSLGE | phosphorylation up-regulates | 17213202 | SIGNOR-234469 |
| CDK3 | NFATC4 | Ser259 | APGPTPAsPRPASPC | phosphorylation up-regulates activity | 27893713 | SIGNOR-278511 |
| p38 | NFATC4 | Ser168 | QGGGAFFsPSPGSSS | phosphorylation down-regulates | 11997522 | SIGNOR-87393 |
| PPP3CA | NFATC4 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-176379 | |
| Calcineurin | NFATC4 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-252322 | |
| MAPK1 | NFATC4 | Ser676 | SNGRRKRsPTQSFRF | phosphorylation up-regulates | 15657420 | SIGNOR-133272 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| p38 | phosphorylation up-regulates → | NFATC4 PSer170 | phosphorylation down-regulates ⊣ | NFATC4 | 11997522 | SIGNOR-87397 |
| MAPK8 | phosphorylation up-regulates → | NFATC4 PSer213 | phosphorylation up-regulates → | NFATC4 | 17875713 | SIGNOR-280032 |
| MAPK8 | phosphorylation up-regulates → | NFATC4 PSer217 | phosphorylation up-regulates → | NFATC4 | 17875713 | SIGNOR-280033 |
| MAPK9 | phosphorylation up-regulates → | NFATC4 PSer213 | phosphorylation up-regulates → | NFATC4 | 17875713 | SIGNOR-280035 |
| MAPK9 | phosphorylation up-regulates → | NFATC4 PSer217 | phosphorylation up-regulates → | NFATC4 | 17875713 | SIGNOR-280036 |
| RPS6KA3 | phosphorylation up-regulates → | NFATC4 PSer289 | phosphorylation up-regulates → | NFATC4 | 17213202 | SIGNOR-234473 |
| RPS6KA3 | phosphorylation up-regulates → | NFATC4 PSer281 | phosphorylation up-regulates → | NFATC4 | 17213202 | SIGNOR-234465 |
| MAPK3 | phosphorylation up-regulates → | NFATC4 PSer676 | phosphorylation up-regulates → | NFATC4 | 15657420 | SIGNOR-133276 |
| RPS6KA3 | phosphorylation up-regulates → | NFATC4 PSer676 | phosphorylation up-regulates → | NFATC4 | 15657420 | SIGNOR-133283 |
| RPS6KA3 | phosphorylation up-regulates → | NFATC4 PSer344 | phosphorylation up-regulates → | NFATC4 | 17213202 | SIGNOR-235652 |
| MAPK14 | phosphorylation up-regulates → | NFATC4 PSer170 | phosphorylation down-regulates ⊣ | NFATC4 | 11997522 | SIGNOR-250108 |
| MAPK14 | phosphorylation up-regulates → | NFATC4 PSer168 | phosphorylation down-regulates ⊣ | NFATC4 | 11997522 | SIGNOR-250107 |
| RPS6KA3 | phosphorylation up-regulates → | NFATC4 PSer285 | phosphorylation up-regulates → | NFATC4 | 17213202 | SIGNOR-234469 |
| CDK3 | phosphorylation up-regulates → | NFATC4 PSer259 | phosphorylation up-regulates → | NFATC4 | 27893713 | SIGNOR-278511 |
| p38 | phosphorylation up-regulates → | NFATC4 PSer168 | phosphorylation down-regulates ⊣ | NFATC4 | 11997522 | SIGNOR-87393 |
| MAPK1 | phosphorylation up-regulates → | NFATC4 PSer676 | phosphorylation up-regulates → | NFATC4 | 15657420 | SIGNOR-133272 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| p38 | phosphorylation down-regulates | NFATC4 | SIGNOR-87397 |
| MAPK8 | phosphorylation → up-regulates activity | NFATC4 | SIGNOR-280032 |
| MAPK8 | phosphorylation → up-regulates activity | NFATC4 | SIGNOR-280033 |
| MAPK9 | phosphorylation → up-regulates activity | NFATC4 | SIGNOR-280035 |
| MAPK9 | phosphorylation → up-regulates activity | NFATC4 | SIGNOR-280036 |
| RPS6KA3 | phosphorylation → up-regulates | NFATC4 | SIGNOR-234473 |
| RPS6KA3 | phosphorylation → up-regulates | NFATC4 | SIGNOR-234465 |
| MAPK3 | phosphorylation → up-regulates | NFATC4 | SIGNOR-133276 |
| RPS6KA3 | phosphorylation → up-regulates | NFATC4 | SIGNOR-133283 |
| ERK1/2 | phosphorylation → up-regulates | NFATC4 | SIGNOR-270160 |
| RPS6KA3 | phosphorylation → up-regulates | NFATC4 | SIGNOR-235652 |
| MAPK14 | phosphorylation → down-regulates activity | NFATC4 | SIGNOR-250108 |
| MAPK14 | phosphorylation → down-regulates activity | NFATC4 | SIGNOR-250107 |
| Gbeta | phosphorylation → up-regulates | NFATC4 | SIGNOR-270047 |
| RPS6KA3 | phosphorylation → up-regulates | NFATC4 | SIGNOR-234469 |
| CDK3 | phosphorylation → up-regulates activity | NFATC4 | SIGNOR-278511 |
| p38 | phosphorylation down-regulates | NFATC4 | SIGNOR-87393 |
| PPP3CA | dephosphorylation → up-regulates | NFATC4 | SIGNOR-176379 |
| Calcineurin | dephosphorylation → up-regulates | NFATC4 | SIGNOR-252322 |
| MAPK1 | phosphorylation → up-regulates | NFATC4 | SIGNOR-133272 |