Summary

Name NFATC4
Full Name Nuclear factor of activated T-cells, cytoplasmic 4
Synonyms NF-ATc4, NFATc4, T-cell transcription factor NFAT3, NF-AT3 | NFAT3
Primary ID Q14934
Links - -
Type protein
Relations 13
Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation NFATC4 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NFATC4 0.14
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation NFATC4 0.37
Publications: 5 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates img/direct-activation.png phosphorylation NFATC4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NFATC4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation NFATC4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation NFATC4 0.14
Publications: 1 Organism: Homo Sapiens