| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | CDK5R1 | Thr138 | PAVTSAGtPKRVIVQ | phosphorylation down-regulates | 18326489 | SIGNOR-177967 |
| SIK2 | CDK5R1 | Ser91 | ENLKKSLsCANLSTF | phosphorylation down-regulates | 24561619 | SIGNOR-204648 |
| CDK5 | CDK5R1 | Ser8 | MGTVLSLsPSYRKAT | phosphorylation down-regulates | 18326489 | SIGNOR-177963 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | phosphorylation up-regulates → | CDK5R1 PThr138 | phosphorylation down-regulates ⊣ | CDK5R1 | 18326489 | SIGNOR-177967 |
| SIK2 | phosphorylation up-regulates → | CDK5R1 PSer91 | phosphorylation down-regulates ⊣ | CDK5R1 | 24561619 | SIGNOR-204648 |
| CDK5 | phosphorylation up-regulates → | CDK5R1 PSer8 | phosphorylation down-regulates ⊣ | CDK5R1 | 18326489 | SIGNOR-177963 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5 | phosphorylation down-regulates | CDK5R1 | SIGNOR-177967 |
| SIK2 | phosphorylation down-regulates | CDK5R1 | SIGNOR-204648 |
| CDK5 | phosphorylation down-regulates | CDK5R1 | SIGNOR-177963 |
