| + |
CDK5 | down-regulates 
phosphorylation
|
CDK5R1 |
0.942 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177963 |
Ser8 |
MGTVLSLsPSYRKAT |
Homo sapiens |
|
| pmid |
sentence |
| 18326489 |
When overexpressed with cdk5, a large fraction of the double mutant p35(s8a/t138a) co-sedimented with microtubules (fig. 5b), further supporting the idea that the phosphorylation at these two residues by cdk5 is inhibitory to the microtubule association. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177967 |
Thr138 |
PAVTSAGtPKRVIVQ |
Homo sapiens |
|
| pmid |
sentence |
| 18326489 |
P35 phosphorylation by cdk5 interferes with the microtubule-binding and polymerizing activities of p35. Using a mutational approach, we found that only phosphorylation at thr-138, one of the two residues primarily phosphorylated in vivo, inhibits the polymerizing activity |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SIK2 | down-regulates
phosphorylation
|
CDK5R1 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204648 |
Ser91 |
ENLKKSLsCANLSTF |
Homo sapiens |
|
| pmid |
sentence |
| 24561619 |
Sik2 phosphorylates p35 at ser 91, to trigger its ubiquitylation by pja2 and promote insulin secretion. _-cell knockout of sik2 leads to accumulation of p35 and impaired secretion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5R1 | up-regulates activity 
binding
|
CDK5 |
0.942 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268153 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 10604467 |
Cyclin-dependent kinase 5 (Cdk5) is required for proper development of the mammalian central nervous system. To be activated, Cdk5 has to associate with its regulatory subunit, p35. We have found that p25, a truncated form of p35, accumulates in neurons in the brains of patients with Alzheimer's disease. This accumulation correlates with an increase in Cdk5 kinase activity. Unlike p35, p25 is not readily degraded, and binding of p25 to Cdk5 constitutively activates Cdk5, changes its cellular location and alters its substrate specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5R1 | up-regulates
binding
|
CDK5 |
0.942 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123387 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15013773 |
In brain, p35 or p25 exists with and activates cdk5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAPN3 | up-regulates activity
cleavage
|
CDK5R1 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251604 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25969760 |
Calpains also modulate the activity of CDK5. Physiologically, CDK 5 is activated by p35 and its cleaved product p25. The latter has a longer half life than p35 and therefore it is a more potent activator of CDK5. The cleavage of p35 to p25 is mediated by calpain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHN1 | up-regulates
binding
|
CDK5R1 |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123439 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15013773 |
_-chimaerin was identified to interact with the p35 activator of cdk5. The complex of _-chimaerin, cdk5 and p35 is enzymatically functional |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAPN1 | up-regulates activity
cleavage
|
CDK5R1 |
0.552 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251583 |
|
|
Homo sapiens |
Alzheimer Disease Specific Cell Type |
| pmid |
sentence |
| 25969760 |
Calpains also modulate the activity of CDK5. Physiologically, CDK 5 is activated by p35 and its cleaved product p25. The latter has a longer half life than p35 and therefore it is a more potent activator of CDK5. The cleavage of p35 to p25 is mediated by calpain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer |
| + |
HNRNPA2B1 | down-regulates quantity by repression 
transcriptional regulation
|
CDK5R1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205023 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24792867 |
Hnrnpa2/b1 protein directly interacts with the r1 and r2 regions ofcdk5r13_-utr and displays a negative regulatory activity on its expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5R1 | form complex 
binding
|
CDK5/CDK5R1 |
0.942 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331872 |
Induced p35 forms a complex with Cdk5 and activates its kinase activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Alzheimer |
| + |
CAPN2 | up-regulates activity
cleavage
|
CDK5R1 |
0.545 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251610 |
|
|
Homo sapiens |
Alzheimer Disease Specific Cell Type |
| pmid |
sentence |
| 25969760 |
Calpains also modulate the activity of CDK5. Physiologically, CDK 5 is activated by p35 and its cleaved product p25. The latter has a longer half life than p35 and therefore it is a more potent activator of CDK5. The cleavage of p35 to p25 is mediated by calpain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AATK | up-regulates
binding
|
CDK5R1 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118403 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 14521924 |
Apoptosis-associated tyrosine kinase is a cdk5 activator p35 binding protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
3.0
CDK5R1
- 
- 