| Name | PDK1 |
| ID | Q15118 |
| Role | kinase |
| Enzymatic Domains |
Histidine kinase 163-393 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDK1 | ITGB3 | Thr779 | LYKEATStFTNITYR | phosphorylation down-regulates activity | 10896934 | SIGNOR-250264 |
| PDK1 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates | 7782287 | SIGNOR-32977 |
| PDK1 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109547 |
| PDK1 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109551 |
| PDK1 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates activity | 11485553 | SIGNOR-109555 |
| PDK1 | PDHA2 | Ser291 | TYRYHGHsMSDPGVS | phosphorylation down-regulates | 16436377 | SIGNOR-143966 |
| PDK1 | AKT1 | – | phosphorylation up-regulates activity | 15068796 | SIGNOR-278973 | |
| PDK1 | AKT2 | – | phosphorylation up-regulates activity | 15068796 | SIGNOR-279248 | |
| PDK1 | PKN2 | Thr816 | GYGDRTStFCGTPEF | phosphorylation up-regulates activity | 10753910 | SIGNOR-250265 |
| PDK1 | PDH | – | phosphorylation down-regulates activity | 16517405 | SIGNOR-267445 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDK1 | phosphorylation up-regulates → | ITGB3 PThr779 | phosphorylation down-regulates ⊣ | ITGB3 | 10896934 | SIGNOR-250264 |
| PDK1 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-32977 |
| PDK1 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109547 |
| PDK1 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109551 |
| PDK1 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109555 |
| PDK1 | phosphorylation up-regulates → | PDHA2 PSer291 | phosphorylation down-regulates ⊣ | PDHA2 | 16436377 | SIGNOR-143966 |
| PDK1 | phosphorylation up-regulates → | PKN2 PThr816 | phosphorylation up-regulates → | PKN2 | 10753910 | SIGNOR-250265 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDK1 | phosphorylation → down-regulates activity | ITGB3 | SIGNOR-250264 |
| PDK1 | phosphorylation down-regulates | PDHA1 | SIGNOR-32977 |
| PDK1 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109547 |
| PDK1 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109551 |
| PDK1 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109555 |
| PDK1 | phosphorylation down-regulates | PDHA2 | SIGNOR-143966 |
| PDK1 | phosphorylation → up-regulates activity | AKT1 | SIGNOR-278973 |
| PDK1 | phosphorylation → up-regulates activity | AKT2 | SIGNOR-279248 |
| PDK1 | phosphorylation → up-regulates activity | PKN2 | SIGNOR-250265 |
| PDK1 | phosphorylation → down-regulates activity | PDH | SIGNOR-267445 |