Summary

Name PDK1
Full Name [Pyruvate dehydrogenase
Synonyms Pyruvate dehydrogenase kinase isoform 1, PDH kinase 1 | PDHK1
Primary ID Q15118
Links - -
Type protein
Relations 10
Function Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation PDHA1 0.42
Publications: 3 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PDHA1 0.42
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PDHA2 0.3
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ITGB3 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PKN2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDK1 0.14
Publications: 3 Organism: Homo Sapiens