Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
FGFR1	PDK1	Tyr136	AEDAKAIyDFTDTVI	phosphorylation up-regulates	22195962	SIGNOR-191719
AKT2	PDK1	Thr346	APRPRVEtSRAVPLA	phosphorylation up-regulates activity	27505672	SIGNOR-277271
AKT1	PDK1	Thr346	APRPRVEtSRAVPLA	phosphorylation up-regulates activity	27505672	SIGNOR-277272
PGK1	PDK1	Thr338	LFNYMYStAPRPRVE	phosphorylation up-regulates activity	26942675	SIGNOR-278365
FGFR1	PDK1	Tyr243	ARRLCDLyYINSPEL	phosphorylation up-regulates	22195962	SIGNOR-191723
FGFR1	PDK1	Tyr244	RRLCDLYyINSPELE	phosphorylation up-regulates	22195962	SIGNOR-193454

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
FGFR1	phosphorylation up-regulates →	PDK1 PTyr136	phosphorylation up-regulates →	PDK1	22195962	SIGNOR-191719
AKT2	phosphorylation up-regulates →	PDK1 PThr346	phosphorylation up-regulates →	PDK1	27505672	SIGNOR-277271
AKT1	phosphorylation up-regulates →	PDK1 PThr346	phosphorylation up-regulates →	PDK1	27505672	SIGNOR-277272
PGK1	phosphorylation up-regulates →	PDK1 PThr338	phosphorylation up-regulates →	PDK1	26942675	SIGNOR-278365
FGFR1	phosphorylation up-regulates →	PDK1 PTyr243	phosphorylation up-regulates →	PDK1	22195962	SIGNOR-191723
FGFR1	phosphorylation up-regulates →	PDK1 PTyr244	phosphorylation up-regulates →	PDK1	22195962	SIGNOR-193454

Regulator	Mechanism/Effect	Target	SIGNOR-ID
FGFR1	phosphorylation → up-regulates	PDK1	SIGNOR-191719
AKT2	phosphorylation → up-regulates activity	PDK1	SIGNOR-277271
AKT1	phosphorylation → up-regulates activity	PDK1	SIGNOR-277272
PGK1	phosphorylation → up-regulates activity	PDK1	SIGNOR-278365
FGFR1	phosphorylation → up-regulates	PDK1	SIGNOR-191723
FGFR1	phosphorylation → up-regulates	PDK1	SIGNOR-193454