Entity Details

Name PDK3
ID Q15120
Role kinase
Enzymatic Domains
Histidine kinase 131-362
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PDK3PDHA1Ser232NRYGMGTsVERAAASphosphorylation
down-regulates activity		11485553SIGNOR-109613
PDK3PDHA1Ser293TYRYHGHsMSDPGVSphosphorylation
down-regulates activity		11485553SIGNOR-109609
PDK3PDHA1Ser293TYRYHGHsMSDPGVSphosphorylation
down-regulates activity		11486000SIGNOR-109647
PDK3PDHA1Ser300SMSDPGVsYRTREEIphosphorylation
down-regulates activity		11486000SIGNOR-109651
PDK3PDHA2Ser291TYRYHGHsMSDPGVSphosphorylation
down-regulates		16436377SIGNOR-143974
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PDK3phosphorylation
up-regulates
→
PDHA1
PSer232		phosphorylation
down-regulates
⊣		PDHA111485553SIGNOR-109613
PDK3phosphorylation
up-regulates
→
PDHA1
PSer293		phosphorylation
down-regulates
⊣		PDHA111485553SIGNOR-109609
PDK3phosphorylation
up-regulates
→
PDHA1
PSer293		phosphorylation
down-regulates
⊣		PDHA111486000SIGNOR-109647
PDK3phosphorylation
up-regulates
→
PDHA1
PSer300		phosphorylation
down-regulates
⊣		PDHA111486000SIGNOR-109651
PDK3phosphorylation
up-regulates
→
PDHA2
PSer291		phosphorylation
down-regulates
⊣		PDHA216436377SIGNOR-143974
Regulator Mechanism/Effect Target SIGNOR-ID
PDK3phosphorylation
→
down-regulates activity 		PDHA1SIGNOR-109613
PDK3phosphorylation
→
down-regulates activity 		PDHA1SIGNOR-109609
PDK3phosphorylation
→
down-regulates activity 		PDHA1SIGNOR-109647
PDK3phosphorylation
→
down-regulates activity 		PDHA1SIGNOR-109651
PDK3phosphorylation
img/direct_inhibition.png
down-regulates 		PDHA2SIGNOR-143974