Summary

Name PDK3
Full Name [Pyruvate dehydrogenase
Synonyms Pyruvate dehydrogenase kinase isoform 3 | PDHK3
Primary ID Q15120
Links - -
Type protein
Relations 5
Function Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation PDHA1 0.864
Publications: 4 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation PDHA2 0.541
Publications: 1 Organism: Homo Sapiens