| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | PLEC | Thr4539 | GGLIEPDtPGRVPLD | phosphorylation down-regulates | 19709076 | SIGNOR-187766 |
| CDK1 | PLEC | Thr4539 | GGLIEPDtPGRVPLD | phosphorylation down-regulates | 8626512 | SIGNOR-41319 |
| CyclinB/CDK1 | PLEC | Thr4539 | GGLIEPDtPGRVPLD | phosphorylation down-regulates | 19709076 | SIGNOR-216904 |
| CyclinB/CDK1 | PLEC | Thr4539 | GGLIEPDtPGRVPLD | phosphorylation down-regulates | 8626512 | SIGNOR-216908 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | PLEC PThr4539 | phosphorylation down-regulates ⊣ | PLEC | 19709076 | SIGNOR-187766 |
| CDK1 | phosphorylation up-regulates → | PLEC PThr4539 | phosphorylation down-regulates ⊣ | PLEC | 8626512 | SIGNOR-41319 |
| CyclinB/CDK1 | phosphorylation up-regulates → | PLEC PThr4539 | phosphorylation down-regulates ⊣ | PLEC | 19709076 | SIGNOR-216904 |
| CyclinB/CDK1 | phosphorylation up-regulates → | PLEC PThr4539 | phosphorylation down-regulates ⊣ | PLEC | 8626512 | SIGNOR-216908 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates | PLEC | SIGNOR-187766 |
| CDK1 | phosphorylation down-regulates | PLEC | SIGNOR-41319 |
| CyclinB/CDK1 | phosphorylation down-regulates | PLEC | SIGNOR-216904 |
| CyclinB/CDK1 | phosphorylation down-regulates | PLEC | SIGNOR-216908 |
