| Name | PTPRK |
| ID | Q15262 |
| Role | phosphatase |
| Enzymatic Domains |
MAM 31-194 PROSITE-ProRule
Ig-like C2-type 196-281
Fibronectin type-III 1 294-389 PROSITE-ProRule
Fibronectin type-III 2 392-488 PROSITE-ProRule
Fibronectin type-III 3 491-595 PROSITE-ProRule
Fibronectin type-III 4 597-680 PROSITE-ProRule
Tyrosine-protein phosphatase 1 887-1141 PROSITE-ProRule
Tyrosine-protein phosphatase 2 1173-1435 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRK | PROM1 | – | dephosphorylation down-regulates activity | 30947381 | SIGNOR-277133 | |
| PTPRK | EGFR | Tyr1092 | TFLPVPEyINQSVPK | dephosphorylation unknown | 16263724 | SIGNOR-248722 |
| PTPRK | EGFR | Tyr1197 | STAENAEyLRVAPQS | dephosphorylation unknown | 16263724 | SIGNOR-248723 |
| PTPRK | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | dephosphorylation down-regulates activity | 25612622 | SIGNOR-277060 |
| PTPRK | ZNRF3 | – | dephosphorylation up-regulates activity | 31934854 | SIGNOR-260110 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRK | dephosphorylation down-regulates ⊣ | EGFR PTyr1092 | dephosphorylation up-regulates → | EGFR | 16263724 | SIGNOR-248722 |
| PTPRK | dephosphorylation down-regulates ⊣ | EGFR PTyr1197 | dephosphorylation up-regulates → | EGFR | 16263724 | SIGNOR-248723 |
| PTPRK | dephosphorylation down-regulates ⊣ | STAT3 PTyr705 | dephosphorylation up-regulates → | STAT3 | 25612622 | SIGNOR-277060 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRK | dephosphorylation → down-regulates activity | PROM1 | SIGNOR-277133 |
| PTPRK | dephosphorylation → unknown | EGFR | SIGNOR-248722 |
| PTPRK | dephosphorylation → unknown | EGFR | SIGNOR-248723 |
| PTPRK | dephosphorylation → down-regulates activity | STAT3 | SIGNOR-277060 |
| PTPRK | dephosphorylation → up-regulates activity | ZNRF3 | SIGNOR-260110 |