+ |
PTPRK |
dephosphorylation
|
EGFR |
0.6 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-248722 |
Tyr1092 |
TFLPVPEyINQSVPK |
Cricetulus griseus |
CHO Cell |
pmid |
sentence |
16263724 |
RPTP-kappa also reduced epidermal growth factor-dependent EGFR tyrosine phosphorylation in CHO cells. Purified RPTP-kappa preferentially dephosphorylated EGFR tyrosines 1068 and 1173 in vitro. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-248723 |
Tyr1197 |
STAENAEyLRVAPQS |
Cricetulus griseus |
CHO Cell |
pmid |
sentence |
16263724 |
RPTP-kappa also reduced epidermal growth factor-dependent EGFR tyrosine phosphorylation in CHO cells. Purified RPTP-kappa preferentially dephosphorylated EGFR tyrosines 1068 and 1173 in vitro. |
|
Publications: |
2 |
Organism: |
Cricetulus Griseus |
+ |
PTPRK | up-regulates activity
dephosphorylation
|
ZNRF3 |
0.367 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260110 |
|
|
Homo sapiens |
NCI-H1703 Cell |
pmid |
sentence |
31934854 |
We show that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt signaling promoting Wnt receptor degradation, which is also expressed in the organizer. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |