Entity Details

Name RPS6KA1
ID Q15418
Role kinase
Enzymatic Domains
Protein kinase 1 62-321
PROSITE-ProRule
AGC-kinase C-terminal 322-391
PROSITE-ProRule
Protein kinase 2 418-675
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
RPS6KA1MITFSer409HGLSLIPsTGLCSPDphosphorylation
down-regulates
10673502SIGNOR-75034
RPS6KA1FLNASer2152TRRRRAPsVANVGSHphosphorylation
up-regulates
15024089SIGNOR-123458
RPS6KA1EIF4BSer422RERSRTGsESSQTGTphosphorylation
up-regulates
15071500SIGNOR-123993
RPS6KA1CEBPBphosphorylation
up-regulates activity
22068162SIGNOR-280112
RPS6KA1EPHA2Ser897RVSIRLPsTSGSEGVphosphorylation
up-regulates activity
32574556SIGNOR-280113
RPS6KA1NFKBIBSer19DADEWCDsGLGSLGPphosphorylation
down-regulates quantity by destabilization
16822942SIGNOR-280114
RPS6KA1NFKBIBSer23WCDSGLGsLGPDAAAphosphorylation
down-regulates quantity by destabilization
16822942SIGNOR-280115
RPS6KA1WWC1Ser947CRLNRSDsDSSTLSKphosphorylation
up-regulates
24269383SIGNOR-203294
RPS6KA1BADSer75EIRSRHSsYPAGTEDphosphorylation
down-regulates activity
10558990SIGNOR-180910
RPS6KA1CDC25ASer295TKRRKSMsGASPKESphosphorylation
down-regulates
23708659SIGNOR-202117
RPS6KA1mTORC1phosphorylation
up-regulates
18722121SIGNOR-217553
RPS6KA1H3-3ASer11TKQTARKsTGGKAPRphosphorylation
down-regulates activity
10464286SIGNOR-70428
RPS6KA1SENP2Thr369TDDLLELtEDMEKEIphosphorylation
down-regulates activity
25689261SIGNOR-273839
RPS6KA1TSC2Ser1798GQRKRLIsSVEDFTEphosphorylation
down-regulates
15342917SIGNOR-128634
RPS6KA1EEF2KSer366SPQVRTLsGSRPPLLphosphorylation
down-regulates activity
11500364SIGNOR-109708
RPS6KA1BADSer153SWTRVFQsWWDRNLGphosphorylation
down-regulates activity
10837486SIGNOR-249045
RPS6KA1BADSer75EIRSRHSsYPAGTEDphosphorylation
down-regulates activity
18246127SIGNOR-160635
RPS6KA1L1CAMSer1152RSKGGKYsVKDKEDTphosphorylation
up-regulates activity
8663493SIGNOR-248948
RPS6KA1TSCphosphorylation
down-regulates activity
15342917SIGNOR-217900
RPS6KA1MITFSer409HGLSLIPsTGLCSPDphosphorylation
down-regulates
21749389SIGNOR-174760
RPS6KA1H3-3ASer11TKQTARKsTGGKAPRphosphorylation
down-regulates activity
15994958SIGNOR-138467
RPS6KA1NFKBIASer32LLDDRHDsGLDSMKDphosphorylation
up-regulates activity
10398585SIGNOR-279311
RPS6KA1RPS6KA1Ser221 DHEKKAYsFCGTVEYphosphorylation
up-regulates activity
20048145SIGNOR-162681
RPS6KA1CDC25BSer353VQNKRRRsVTPPEEQphosphorylation
up-regulates
23708659SIGNOR-202121
RPS6KA1OSTF1Ser202TDAVRTLsNAEDYLDphosphorylation
down-regulates activity
21501342SIGNOR-273838
RPS6KA1ZFP36L1phosphorylation
down-regulates activity
25106868SIGNOR-279280
RPS6KA1CCT2Ser260GSRVRVDsTAKVAEIphosphorylation
up-regulates
21440620SIGNOR-172986
RPS6KA1DEPTORSer287SMSSCGSsGYFSSSPphosphorylation
down-regulates
22017877SIGNOR-176887
RPS6KA1RPS6Ser240RLSSLRAsTSKSESSphosphorylation
up-regulates
21233202SIGNOR-171243
RPS6KA1RPTORSer719PCTPRLRsVSSYGNIphosphorylation
up-regulates
18722121SIGNOR-180458
RPS6KA1BADSer118GRELRRMsDEFVDSFphosphorylation
down-regulates activity
10837486SIGNOR-78020
RPS6KA1RANBP3Ser126VKRERTSsLTQFPPSphosphorylation
unknown
18280241SIGNOR-160904
RPS6KA1SLC9A3R1Thr156ELRPRLCtMKKGPSGphosphorylation
up-regulates activity
26862730SIGNOR-278290
RPS6KA1RPTORSer722PRLRSVSsYGNIRAVphosphorylation
up-regulates
18722121SIGNOR-180466
RPS6KA1FOSSer374PSSDSLSsPTLLALphosphorylation
up-regulates activity
16055710SIGNOR-262999
RPS6KA1STK11Ser428SSKIRRLsACKQQphosphorylation
down-regulates activity
25846811SIGNOR-209871
RPS6KA1MXD1Ser145IERIRMDsIGSTVSSphosphorylation
down-regulates
18451027SIGNOR-178586
RPS6KA1RPS6Ser235IAKRRRLsSLRASTSphosphorylation
up-regulates
17360704SIGNOR-153618
RPS6KA1ETV1Ser191HRFRRQLsEPCNSFPphosphorylation
up-regulates activity
12213813SIGNOR-249162
RPS6KA1CARHSP1Ser52TRRTRTFsATVRASQphosphorylation
unknown
15910284SIGNOR-137482
RPS6KA1NR4A3Ser376GRRGRLPsKPKSPLQphosphorylation
unknown
16223362SIGNOR-249297
RPS6KA1FOSSer362AAAHRKGsSSNEPSSphosphorylation
up-regulates activity
8248197SIGNOR-37154
RPS6KA1CDC25BThr355NKRRRSVtPPEEQQEphosphorylation
up-regulates
23708659SIGNOR-202125
RPS6KA1DEPTORSer291CGSSGYFsSSPTLSSphosphorylation
down-regulates
22017877SIGNOR-176891
RPS6KA1MAGI1Ser741QPLERKDsQNSSQHSphosphorylation
up-regulates activity
30944250SIGNOR-273837
RPS6KA1WWC1Thr929STIIRSKtFSPGPQSphosphorylation
up-regulates
24269383SIGNOR-203298
RPS6KA1DEPTORSer286SSMSSCGsSGYFSSSphosphorylation
down-regulates
22017877SIGNOR-176883
RPS6KA1CDKN1BThr198PGLRRRQtphosphorylation
up-regulates activity
19470470SIGNOR-279653
RPS6KA1SLC9A1Ser703MSRARIGsDPLAYEPphosphorylation
up-regulates
10400637SIGNOR-69171
RPS6KA1ETV1Ser216PMYQRQMsEPNIPFPphosphorylation
up-regulates activity
12213813SIGNOR-249163
RPS6KA1Histone H3phosphorylation
down-regulates activity
14625384SIGNOR-265346
RPS6KA1RPS6Ser236AKRRRLSsLRASTSKphosphorylation
up-regulates
17360704SIGNOR-153622
RPS6KA1CICSer173PGKRRTQsLSALPKEphosphorylation
down-regulates
21087211SIGNOR-169883
RPS6KA1RPTORSer721TPRLRSVsSYGNIRAphosphorylation
up-regulates
18722121SIGNOR-180462
RPS6KA1CREB1Ser119EILSRRPsYRKILNDphosphorylation
up-regulates activity
10558990SIGNOR-72117
RPS6KA1ESR1Ser167GGRERLAsTNDKGSMphosphorylation
up-regulates
7838153SIGNOR-34113
RPS6KA1RANBP3Ser57HGTGHPEsAGEHALEphosphorylation
up-regulates quantity
18280241SIGNOR-276149
RPS6KA1METTL1Ser27YYRQRAHsNPMADHTphosphorylation
down-regulates
15861136SIGNOR-135948
RPS6KA1PPP1R3ASer46PQPSRRGsDSSEDIYphosphorylation
up-regulates activity
10648825SIGNOR-249036
RPS6KA1H3-3ASer11TKQTARKsTGGKAPRphosphorylation
down-regulates activity
14625384SIGNOR-119221
RPS6KA1RPS6Ser244LRASTSKsESSQKphosphorylation
up-regulates
21233202SIGNOR-171247
RPS6KA1CDC25ASer293GSTKRRKsMSGASPKphosphorylation
down-regulates
23708659SIGNOR-202113
RPS6KA1IRS1phosphorylation
down-regulates quantity by destabilization
21798082SIGNOR-175687
RPS6KA1CDC34Thr162KGKDREYtDIIRKQVphosphorylation
down-regulates quantity by destabilization
27786305SIGNOR-277330
RPS6KA1YBX1Ser102NPRKYLRsVGDGETVphosphorylation
up-regulates
19036157SIGNOR-182497
RPS6KA1VASPThr278LARRRKAtQVGEKTPphosphorylation
down-regulates
21423205SIGNOR-172899
RPS6KA1GSK3BSer9SGRPRTTsFAESCKPphosphorylation
down-regulates
11584304SIGNOR-110917
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
RPS6KA1phosphorylation
up-regulates
MITF
PSer409
phosphorylation
down-regulates
MITF10673502SIGNOR-75034
RPS6KA1phosphorylation
up-regulates
FLNA
PSer2152
phosphorylation
up-regulates
FLNA15024089SIGNOR-123458
RPS6KA1phosphorylation
up-regulates
EIF4B
PSer422
phosphorylation
up-regulates
EIF4B15071500SIGNOR-123993
RPS6KA1phosphorylation
up-regulates
EPHA2
PSer897
phosphorylation
up-regulates
EPHA232574556SIGNOR-280113
RPS6KA1phosphorylation
up-regulates
NFKBIB
PSer19
phosphorylation
down-regulates
NFKBIB16822942SIGNOR-280114
RPS6KA1phosphorylation
up-regulates
NFKBIB
PSer23
phosphorylation
down-regulates
NFKBIB16822942SIGNOR-280115
RPS6KA1phosphorylation
up-regulates
WWC1
PSer947
phosphorylation
up-regulates
WWC124269383SIGNOR-203294
RPS6KA1phosphorylation
up-regulates
BAD
PSer75
phosphorylation
down-regulates
BAD10558990SIGNOR-180910
RPS6KA1phosphorylation
up-regulates
CDC25A
PSer295
phosphorylation
down-regulates
CDC25A23708659SIGNOR-202117
RPS6KA1phosphorylation
up-regulates
H3-3A
PSer11
phosphorylation
down-regulates
H3-3A10464286SIGNOR-70428
RPS6KA1phosphorylation
up-regulates
SENP2
PThr369
phosphorylation
down-regulates
SENP225689261SIGNOR-273839
RPS6KA1phosphorylation
up-regulates
TSC2
PSer1798
phosphorylation
down-regulates
TSC215342917SIGNOR-128634
RPS6KA1phosphorylation
up-regulates
EEF2K
PSer366
phosphorylation
down-regulates
EEF2K11500364SIGNOR-109708
RPS6KA1phosphorylation
up-regulates
BAD
PSer153
phosphorylation
down-regulates
BAD10837486SIGNOR-249045
RPS6KA1phosphorylation
up-regulates
BAD
PSer75
phosphorylation
down-regulates
BAD18246127SIGNOR-160635
RPS6KA1phosphorylation
up-regulates
L1CAM
PSer1152
phosphorylation
up-regulates
L1CAM8663493SIGNOR-248948
RPS6KA1phosphorylation
up-regulates
MITF
PSer409
phosphorylation
down-regulates
MITF21749389SIGNOR-174760
RPS6KA1phosphorylation
up-regulates
H3-3A
PSer11
phosphorylation
down-regulates
H3-3A15994958SIGNOR-138467
RPS6KA1phosphorylation
up-regulates
NFKBIA
PSer32
phosphorylation
up-regulates
NFKBIA10398585SIGNOR-279311
RPS6KA1phosphorylation
up-regulates
RPS6KA1
PSer221
phosphorylation
up-regulates
RPS6KA120048145SIGNOR-162681
RPS6KA1phosphorylation
up-regulates
CDC25B
PSer353
phosphorylation
up-regulates
CDC25B23708659SIGNOR-202121
RPS6KA1phosphorylation
up-regulates
OSTF1
PSer202
phosphorylation
down-regulates
OSTF121501342SIGNOR-273838
RPS6KA1phosphorylation
up-regulates
CCT2
PSer260
phosphorylation
up-regulates
CCT221440620SIGNOR-172986
RPS6KA1phosphorylation
up-regulates
DEPTOR
PSer287
phosphorylation
down-regulates
DEPTOR22017877SIGNOR-176887
RPS6KA1phosphorylation
up-regulates
RPS6
PSer240
phosphorylation
up-regulates
RPS621233202SIGNOR-171243
RPS6KA1phosphorylation
up-regulates
RPTOR
PSer719
phosphorylation
up-regulates
RPTOR18722121SIGNOR-180458
RPS6KA1phosphorylation
up-regulates
BAD
PSer118
phosphorylation
down-regulates
BAD10837486SIGNOR-78020
RPS6KA1phosphorylation
up-regulates
RANBP3
PSer126
phosphorylation
down-regulates
RANBP318280241SIGNOR-160904
RPS6KA1phosphorylation
up-regulates
SLC9A3R1
PThr156
phosphorylation
up-regulates
SLC9A3R126862730SIGNOR-278290
RPS6KA1phosphorylation
up-regulates
RPTOR
PSer722
phosphorylation
up-regulates
RPTOR18722121SIGNOR-180466
RPS6KA1phosphorylation
up-regulates
FOS
PSer374
phosphorylation
up-regulates
FOS16055710SIGNOR-262999
RPS6KA1phosphorylation
up-regulates
STK11
PSer428
phosphorylation
down-regulates
STK1125846811SIGNOR-209871
RPS6KA1phosphorylation
up-regulates
MXD1
PSer145
phosphorylation
down-regulates
MXD118451027SIGNOR-178586
RPS6KA1phosphorylation
up-regulates
RPS6
PSer235
phosphorylation
up-regulates
RPS617360704SIGNOR-153618
RPS6KA1phosphorylation
up-regulates
ETV1
PSer191
phosphorylation
up-regulates
ETV112213813SIGNOR-249162
RPS6KA1phosphorylation
up-regulates
CARHSP1
PSer52
phosphorylation
down-regulates
CARHSP115910284SIGNOR-137482
RPS6KA1phosphorylation
up-regulates
NR4A3
PSer376
phosphorylation
down-regulates
NR4A316223362SIGNOR-249297
RPS6KA1phosphorylation
up-regulates
FOS
PSer362
phosphorylation
up-regulates
FOS8248197SIGNOR-37154
RPS6KA1phosphorylation
up-regulates
CDC25B
PThr355
phosphorylation
up-regulates
CDC25B23708659SIGNOR-202125
RPS6KA1phosphorylation
up-regulates
DEPTOR
PSer291
phosphorylation
down-regulates
DEPTOR22017877SIGNOR-176891
RPS6KA1phosphorylation
up-regulates
MAGI1
PSer741
phosphorylation
up-regulates
MAGI130944250SIGNOR-273837
RPS6KA1phosphorylation
up-regulates
WWC1
PThr929
phosphorylation
up-regulates
WWC124269383SIGNOR-203298
RPS6KA1phosphorylation
up-regulates
DEPTOR
PSer286
phosphorylation
down-regulates
DEPTOR22017877SIGNOR-176883
RPS6KA1phosphorylation
up-regulates
CDKN1B
PThr198
phosphorylation
up-regulates
CDKN1B19470470SIGNOR-279653
RPS6KA1phosphorylation
up-regulates
SLC9A1
PSer703
phosphorylation
up-regulates
SLC9A110400637SIGNOR-69171
RPS6KA1phosphorylation
up-regulates
ETV1
PSer216
phosphorylation
up-regulates
ETV112213813SIGNOR-249163
RPS6KA1phosphorylation
up-regulates
RPS6
PSer236
phosphorylation
up-regulates
RPS617360704SIGNOR-153622
RPS6KA1phosphorylation
up-regulates
CIC
PSer173
phosphorylation
down-regulates
CIC21087211SIGNOR-169883
RPS6KA1phosphorylation
up-regulates
RPTOR
PSer721
phosphorylation
up-regulates
RPTOR18722121SIGNOR-180462
RPS6KA1phosphorylation
up-regulates
CREB1
PSer119
phosphorylation
up-regulates
CREB110558990SIGNOR-72117
RPS6KA1phosphorylation
up-regulates
ESR1
PSer167
phosphorylation
up-regulates
ESR17838153SIGNOR-34113
RPS6KA1phosphorylation
up-regulates
RANBP3
PSer57
phosphorylation
up-regulates
RANBP318280241SIGNOR-276149
RPS6KA1phosphorylation
up-regulates
METTL1
PSer27
phosphorylation
down-regulates
METTL115861136SIGNOR-135948
RPS6KA1phosphorylation
up-regulates
PPP1R3A
PSer46
phosphorylation
up-regulates
PPP1R3A10648825SIGNOR-249036
RPS6KA1phosphorylation
up-regulates
H3-3A
PSer11
phosphorylation
down-regulates
H3-3A14625384SIGNOR-119221
RPS6KA1phosphorylation
up-regulates
RPS6
PSer244
phosphorylation
up-regulates
RPS621233202SIGNOR-171247
RPS6KA1phosphorylation
up-regulates
CDC25A
PSer293
phosphorylation
down-regulates
CDC25A23708659SIGNOR-202113
RPS6KA1phosphorylation
up-regulates
CDC34
PThr162
phosphorylation
down-regulates
CDC3427786305SIGNOR-277330
RPS6KA1phosphorylation
up-regulates
YBX1
PSer102
phosphorylation
up-regulates
YBX119036157SIGNOR-182497
RPS6KA1phosphorylation
up-regulates
VASP
PThr278
phosphorylation
down-regulates
VASP21423205SIGNOR-172899
RPS6KA1phosphorylation
up-regulates
GSK3B
PSer9
phosphorylation
down-regulates
GSK3B11584304SIGNOR-110917
Regulator Mechanism/Effect Target SIGNOR-ID
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
MITFSIGNOR-75034
RPS6KA1phosphorylation

up-regulates
FLNASIGNOR-123458
RPS6KA1phosphorylation

up-regulates
EIF4BSIGNOR-123993
RPS6KA1phosphorylation

up-regulates activity
CEBPBSIGNOR-280112
RPS6KA1phosphorylation

up-regulates activity
EPHA2SIGNOR-280113
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
NFKBIBSIGNOR-280114
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
NFKBIBSIGNOR-280115
RPS6KA1phosphorylation

up-regulates
WWC1SIGNOR-203294
RPS6KA1phosphorylation

down-regulates activity
BADSIGNOR-180910
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
CDC25ASIGNOR-202117
RPS6KA1phosphorylation

up-regulates
mTORC1SIGNOR-217553
RPS6KA1phosphorylation

down-regulates activity
H3-3ASIGNOR-70428
RPS6KA1phosphorylation

down-regulates activity
SENP2SIGNOR-273839
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
TSC2SIGNOR-128634
RPS6KA1phosphorylation

down-regulates activity
EEF2KSIGNOR-109708
RPS6KA1phosphorylation

down-regulates activity
BADSIGNOR-249045
RPS6KA1phosphorylation

down-regulates activity
BADSIGNOR-160635
RPS6KA1phosphorylation

up-regulates activity
L1CAMSIGNOR-248948
RPS6KA1phosphorylation

down-regulates activity
TSCSIGNOR-217900
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
MITFSIGNOR-174760
RPS6KA1phosphorylation

down-regulates activity
H3-3ASIGNOR-138467
RPS6KA1phosphorylation

up-regulates activity
NFKBIASIGNOR-279311
RPS6KA1phosphorylation

up-regulates activity
RPS6KA1SIGNOR-162681
RPS6KA1phosphorylation

up-regulates
CDC25BSIGNOR-202121
RPS6KA1phosphorylation

down-regulates activity
OSTF1SIGNOR-273838
RPS6KA1phosphorylation

down-regulates activity
ZFP36L1SIGNOR-279280
RPS6KA1phosphorylation

up-regulates
CCT2SIGNOR-172986
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
DEPTORSIGNOR-176887
RPS6KA1phosphorylation

up-regulates
RPS6SIGNOR-171243
RPS6KA1phosphorylation

up-regulates
RPTORSIGNOR-180458
RPS6KA1phosphorylation

down-regulates activity
BADSIGNOR-78020
RPS6KA1phosphorylation

unknown
RANBP3SIGNOR-160904
RPS6KA1phosphorylation

up-regulates activity
SLC9A3R1SIGNOR-278290
RPS6KA1phosphorylation

up-regulates
RPTORSIGNOR-180466
RPS6KA1phosphorylation

up-regulates activity
FOSSIGNOR-262999
RPS6KA1phosphorylation

down-regulates activity
STK11SIGNOR-209871
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
MXD1SIGNOR-178586
RPS6KA1phosphorylation

up-regulates
RPS6SIGNOR-153618
RPS6KA1phosphorylation

up-regulates activity
ETV1SIGNOR-249162
RPS6KA1phosphorylation

unknown
CARHSP1SIGNOR-137482
RPS6KA1phosphorylation

unknown
NR4A3SIGNOR-249297
RPS6KA1phosphorylation

up-regulates activity
FOSSIGNOR-37154
RPS6KA1phosphorylation

up-regulates
CDC25BSIGNOR-202125
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
DEPTORSIGNOR-176891
RPS6KA1phosphorylation

up-regulates activity
MAGI1SIGNOR-273837
RPS6KA1phosphorylation

up-regulates
WWC1SIGNOR-203298
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
DEPTORSIGNOR-176883
RPS6KA1phosphorylation

up-regulates activity
CDKN1BSIGNOR-279653
RPS6KA1phosphorylation

up-regulates
SLC9A1SIGNOR-69171
RPS6KA1phosphorylation

up-regulates activity
ETV1SIGNOR-249163
RPS6KA1phosphorylation

down-regulates activity
Histone H3SIGNOR-265346
RPS6KA1phosphorylation

up-regulates
RPS6SIGNOR-153622
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
CICSIGNOR-169883
RPS6KA1phosphorylation

up-regulates
RPTORSIGNOR-180462
RPS6KA1phosphorylation

up-regulates activity
CREB1SIGNOR-72117
RPS6KA1phosphorylation

up-regulates
ESR1SIGNOR-34113
RPS6KA1phosphorylation

up-regulates quantity
RANBP3SIGNOR-276149
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
METTL1SIGNOR-135948
RPS6KA1phosphorylation

up-regulates activity
PPP1R3ASIGNOR-249036
RPS6KA1phosphorylation

down-regulates activity
H3-3ASIGNOR-119221
RPS6KA1phosphorylation

up-regulates
RPS6SIGNOR-171247
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
CDC25ASIGNOR-202113
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
IRS1SIGNOR-175687
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization
CDC34SIGNOR-277330
RPS6KA1phosphorylation

up-regulates
YBX1SIGNOR-182497
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
VASPSIGNOR-172899
RPS6KA1phosphorylation
img/direct_inhibition.png
down-regulates
GSK3BSIGNOR-110917