Summary

Name RPS6KA1
Full Name Ribosomal protein S6 kinase alpha-1
Synonyms S6K-alpha-1, 90 kDa ribosomal protein S6 kinase 1, p90-RSK 1, p90RSK1, p90S6K, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, Ribosomal S6 kinase 1, RSK-1 | MAPKAPK1A, RSK1
Primary ID Q15418
Links - -
Type protein
Relations 87
Pathways AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, MTOR Signaling
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation YBX1 0.545
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation H3-3A 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation L1CAM 0.504
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.396
Publications: 4 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Inhibition of Apoptosis
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.747
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis
+ img/unknown.png phosphorylation RANBP3 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MXD1 0.316
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.496
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CIC 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC2 0.767
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ETV1 0.351
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation OSTF1 0.353
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FLNA 0.384
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.2
Publications: 6 Organism: Chlorocebus Aethiops
Pathways:AMPK Signaling, FLT3-ITD signaling, Inhibition of Apoptosis, MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.629
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:AMPK Signaling, FLT3-ITD signaling, MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.759
Publications: 8 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.717
Publications: 8 Organism: Chlorocebus Aethiops, Mus Musculus, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6 0.591
Publications: 4 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation CCT2 0.249
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation METTL1 0.325
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DEPTOR 0.494
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDC25A 0.367
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC25B 0.253
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.531
Publications: 2 Organism: Homo Sapiens,
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.515
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NR4A3 0.315
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MITF 0.411
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EIF4B 0.532
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.288
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R3A 0.429
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CARHSP1 0.333
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates quantity img/direct-activation.png phosphorylation RANBP3 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SLC9A1 0.453
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPTOR 0.549
Publications: 3 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAGI1 0.287
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.36
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation WWC1 0.336
Publications: 2 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/direct-activation.png phosphorylation SLC9A3R1 0.331
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDC34 0.336
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation VASP 0.452
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SENP2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA1 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png ubiquitination RPS6KA1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation mTORC1 0.46
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates img/indirect-activation.png Translational_regulation 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RPS6KA1 0.358
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation TSC 0.722
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.359
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:AMPK Signaling, MTOR Signaling