| Name | RPS6KA1 |
| ID | Q15418 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 1 62-321 PROSITE-ProRule
AGC-kinase C-terminal 322-391 PROSITE-ProRule
Protein kinase 2 418-675 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | RPS6KA1 | – | phosphorylation up-regulates activity | 12832467 | SIGNOR-102648 | |
| MAPK3 | RPS6KA1 | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9430688 | SIGNOR-219353 |
| RPS6KA1 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 20048145 | SIGNOR-162681 |
| MAPK1 | RPS6KA1 | Ser363 | TSRTPKDsPGIPPSA | phosphorylation up-regulates activity | 9430688 | SIGNOR-219312 |
| MAPK3 | RPS6KA1 | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-219349 |
| MAPK3 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-219332 |
| MAPK1 | RPS6KA1 | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-219324 |
| PDPK1 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 10480933 | SIGNOR-250270 |
| ERK1/2 | RPS6KA1 | Ser363 | TSRTPKDsPGIPPSA | phosphorylation up-regulates activity | 9430688 | SIGNOR-250554 |
| ERK1/2 | RPS6KA1 | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9430688 | SIGNOR-250558 |
| ERK1/2 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-250553 |
| MAPK3 | RPS6KA1 | Ser732 | RRVRKLPsTTL | phosphorylation up-regulates activity | 9430688 | SIGNOR-219345 |
| MAPK3 | RPS6KA1 | – | phosphorylation up-regulates activity | 8387505 | SIGNOR-38999 | |
| MAPK3 | RPS6KA1 | Ser380 | HQLFRGFsFVATGLM | phosphorylation up-regulates activity | 9430688 | SIGNOR-219341 |
| ERK1/2 | RPS6KA1 | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-250557 |
| Gbeta | RPS6KA1 | – | phosphorylation up-regulates activity | 8387505 | SIGNOR-270002 | |
| MAPK1 | RPS6KA1 | Ser380 | HQLFRGFsFVATGLM | phosphorylation up-regulates activity | 9430688 | SIGNOR-219316 |
| MAPK1 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-219308 |
| MAPK3 | RPS6KA1 | Ser363 | TSRTPKDsPGIPPSA | phosphorylation up-regulates activity | 9430688 | SIGNOR-219337 |
| MAPK1 | RPS6KA1 | Ser732 | RRVRKLPsTTL | phosphorylation up-regulates activity | 9430688 | SIGNOR-219320 |
| MAPK1 | RPS6KA1 | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9430688 | SIGNOR-219328 |
| MAPK1 | RPS6KA1 | – | phosphorylation up-regulates activity | 12832467 | SIGNOR-102645 | |
| MAPK1 | RPS6KA1 | Thr573 | AENGLLMtPCYTANF | phosphorylation up-regulates activity | 9687510 | SIGNOR-59363 |
| ERK1/2 | RPS6KA1 | Ser732 | RRVRKLPsTTL | phosphorylation up-regulates activity | 9430688 | SIGNOR-250556 |
| ERK1/2 | RPS6KA1 | Ser380 | HQLFRGFsFVATGLM | phosphorylation up-regulates activity | 9430688 | SIGNOR-250555 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | RPS6KA1 PThr573 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219353 |
| RPS6KA1 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 20048145 | SIGNOR-162681 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA1 PSer363 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219312 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA1 PThr359 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219349 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219332 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA1 PThr359 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219324 |
| PDPK1 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 10480933 | SIGNOR-250270 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PSer363 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250554 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PThr573 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250558 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250553 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA1 PSer732 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219345 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA1 PSer380 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219341 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PThr359 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250557 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA1 PSer380 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219316 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219308 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA1 PSer363 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219337 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA1 PSer732 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219320 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA1 PThr573 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219328 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA1 PThr573 | phosphorylation up-regulates → | RPS6KA1 | 9687510 | SIGNOR-59363 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PSer732 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250556 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PSer380 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250555 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-102648 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219353 |
| RPS6KA1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-162681 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219312 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219349 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219332 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219324 |
| PDPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250270 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250554 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250558 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250553 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219345 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-38999 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219341 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250557 |
| Gbeta | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-270002 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219316 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219308 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219337 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219320 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219328 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-102645 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-59363 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250556 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250555 |