| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | RPS6KA1 | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-219324 |
| MAPK3 | RPS6KA1 | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-219349 |
| ERK1/2 | RPS6KA1 | Thr359 | DTEFTSRtPKDSPGI | phosphorylation up-regulates activity | 9430688 | SIGNOR-250557 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | RPS6KA1 PThr359 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219324 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA1 PThr359 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219349 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PThr359 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250557 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219324 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219349 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250557 |