| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDPK1 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 10480933 | SIGNOR-250270 |
| MAPK3 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-219332 |
| ERK1/2 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-250553 |
| RPS6KA1 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 20048145 | SIGNOR-162681 |
| MAPK1 | RPS6KA1 | Ser221 | DHEKKAYsFCGTVEY | phosphorylation up-regulates activity | 9430688 | SIGNOR-219308 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDPK1 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 10480933 | SIGNOR-250270 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219332 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-250553 |
| RPS6KA1 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 20048145 | SIGNOR-162681 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA1 PSer221 | phosphorylation up-regulates → | RPS6KA1 | 9430688 | SIGNOR-219308 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250270 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219332 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-250553 |
| RPS6KA1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-162681 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA1 | SIGNOR-219308 |