| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | NFKBIB | Ser19 | DADEWCDsGLGSLGP | phosphorylation down-regulates quantity by destabilization | 16822942 | SIGNOR-280114 |
| RPS6KA1 | NFKBIB | Ser23 | WCDSGLGsLGPDAAA | phosphorylation down-regulates quantity by destabilization | 16822942 | SIGNOR-280115 |
| IKBKB | NFKBIB | – | phosphorylation down-regulates | 9346241 | SIGNOR-52932 | |
| MAP3K7 | NFKBIB | – | phosphorylation down-regulates | 9480845 | SIGNOR-55719 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA1 | phosphorylation up-regulates → | NFKBIB PSer19 | phosphorylation down-regulates ⊣ | NFKBIB | 16822942 | SIGNOR-280114 |
| RPS6KA1 | phosphorylation up-regulates → | NFKBIB PSer23 | phosphorylation down-regulates ⊣ | NFKBIB | 16822942 | SIGNOR-280115 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA1 | phosphorylation![]() down-regulates quantity by destabilization | NFKBIB | SIGNOR-280114 |
| RPS6KA1 | phosphorylation![]() down-regulates quantity by destabilization | NFKBIB | SIGNOR-280115 |
| IKBKB | phosphorylation![]() down-regulates | NFKBIB | SIGNOR-52932 |
| MAP3K7 | phosphorylation![]() down-regulates | NFKBIB | SIGNOR-55719 |