| + |
RPS6KA1 | down-regulates quantity by destabilization
phosphorylation
|
NFKBIB |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280114 |
Ser19 |
DADEWCDsGLGSLGP |
Homo sapiens |
|
| pmid |
sentence |
| 16822942 |
By using recombinant wild-type and mutant IkappaBbeta proteins, both active ERK2 and RSK1 were found to directly phosphorylate IkappaBbeta, but only active RSK1 phosphorylated IkappaBbeta on Ser19 and Ser23, two sites known to mediate the subsequent ubiquitination and degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280115 |
Ser23 |
WCDSGLGsLGPDAAA |
Homo sapiens |
|
| pmid |
sentence |
| 16822942 |
By using recombinant wild-type and mutant IkappaBbeta proteins, both active ERK2 and RSK1 were found to directly phosphorylate IkappaBbeta, but only active RSK1 phosphorylated IkappaBbeta on Ser19 and Ser23, two sites known to mediate the subsequent ubiquitination and degradation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
BTRC | down-regulates quantity by destabilization
binding
|
NFKBIB |
0.583 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272554 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 10514424 |
Interaction with beta-TrCP is also necessary for ubiquitination of IkappaBbeta upon stimulation of cells, and deletion of the F-box in beta-TrCP abolishes its ability to ubiquitinate IkappaBbeta. Therefore, these results indicate that beta-TrCP plays a critical role in the activation of NF-kappaB by assembling the ubiquitin ligase complex for both phosphorylated IkappaBalpha and IkappaBbeta.β-TrCP recognizes IκBα phosphorylated at Ser-32 and Ser-36 through its WD40 domain, whereas the F-box motif recruits additional proteins including Skp1 and Cullin to form the Skp1-cullin-F-box (SCF) ubiquitin ligase complex |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
IKBKB | down-regulates
phosphorylation
|
NFKBIB |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-52932 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9346241 |
We described the purification of a 900 kda protein kinase complex, the ikb kinase (ikk), that phosphorylates ikbalfa and ikbbeta at the sites that mediate their ubiquitination and degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization
polyubiquitination
|
NFKBIB |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272556 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 10514424 |
Interaction with beta-TrCP is also necessary for ubiquitination of IkappaBbeta upon stimulation of cells, and deletion of the F-box in beta-TrCP abolishes its ability to ubiquitinate IkappaBbeta. Therefore, these results indicate that beta-TrCP plays a critical role in the activation of NF-kappaB by assembling the ubiquitin ligase complex for both phosphorylated IkappaBalpha and IkappaBbeta.β-TrCP recognizes IκBα phosphorylated at Ser-32 and Ser-36 through its WD40 domain, whereas the F-box motif recruits additional proteins including Skp1 and Cullin to form the Skp1-cullin-F-box (SCF) ubiquitin ligase complex |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
MAP3K7 | down-regulates
phosphorylation
|
NFKBIB |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9480845 |
Overexpression oftak1together with its activator protein,tak1binding protein 1 (tab1), induced thenucleartranslocation of nf-kappa b p50/p65 heterodimer accompanied by the degradation of i kappa b alpha and i kappa b beta, and the expression of kappa b-dependent reporter gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |