Entity Details

Name PTPN14
ID Q15678
Role phosphatase
Enzymatic Domains
FERM 21-306
PROSITE-ProRule
Tyrosine-protein phosphatase 909-1180
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN14STAT3–dephosphorylation
down-regulates activity		35259601SIGNOR-277088
PTPN14BCAR1Tyr128SKAQQGLyQVPGPSPdephosphorylation
down-regulates		22710723SIGNOR-197923
PTPN14CAV1–dephosphorylation
down-regulates activity		32152405SIGNOR-277054
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN14dephosphorylation
down-regulates
⊣
BCAR1
PTyr128		dephosphorylation
up-regulates
→		BCAR122710723SIGNOR-197923
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN14dephosphorylation
→
down-regulates activity 		STAT3SIGNOR-277088
PTPN14dephosphorylation
img/direct_inhibition.png
down-regulates 		BCAR1SIGNOR-197923
PTPN14dephosphorylation
→
down-regulates activity 		CAV1SIGNOR-277054