Summary

Name PTPN14
Full Name Tyrosine-protein phosphatase non-receptor type 14
Synonyms Protein-tyrosine phosphatase pez | PEZ, PTPD2
Primary ID Q15678
Links - -
Type protein
Relations 1
Function Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png dephosphorylation BCAR1 0.408
Publications: 1 Organism: Homo Sapiens