| Name | ELAVL1 |
| ID | Q15717 |
| Role | substrate |
| Enzymatic Domains |
RRM 1 20-98 PROSITE-ProRule
RRM 2 106-186 PROSITE-ProRule
RRM 3 244-322 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | ELAVL1 | Ser202 | LLSQLYHsPARRFGG | phosphorylation down-regulates activity | 22936947 | SIGNOR-279014 |
| CHUK | ELAVL1 | Ser304 | EAAMAIAsLNGYRLG | phosphorylation down-regulates quantity by destabilization | 23115237 | SIGNOR-276422 |
| MAPK15 | ELAVL1 | – | phosphorylation down-regulates activity | 26595526 | SIGNOR-278314 | |
| CHEK2 | ELAVL1 | Thr118 | SGLPRTMtQKDVEDM | phosphorylation down-regulates activity | 21745814 | SIGNOR-278162 |
| PRKCD | ELAVL1 | Ser318 | GDKILQVsFKTNKSH | phosphorylation up-regulates | 20086103 | SIGNOR-163528 |
| MAPK14 | ELAVL1 | – | phosphorylation up-regulates | 19528229 | SIGNOR-186138 | |
| CHEK2 | ELAVL1 | Ser100 | VSYARPSsEVIKDAN | phosphorylation up-regulates activity | 21745814 | SIGNOR-278161 |
| PRKCD | ELAVL1 | Ser221 | QAQRFRFsPMGVDHM | phosphorylation up-regulates | 20086103 | SIGNOR-163524 |
| MAPK14 | ELAVL1 | Thr118 | SGLPRTMtQKDVEDM | phosphorylation up-regulates | 19528229 | SIGNOR-186135 |
| MAPKAPK2 | ELAVL1 | – | phosphorylation up-regulates | 20626350 | SIGNOR-166622 | |
| CHEK2 | ELAVL1 | Ser88 | LNGLRLQsKTIKVSY | phosphorylation down-regulates activity | 21745814 | SIGNOR-278163 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | ELAVL1 PSer202 | phosphorylation down-regulates ⊣ | ELAVL1 | 22936947 | SIGNOR-279014 |
| CHUK | phosphorylation up-regulates → | ELAVL1 PSer304 | phosphorylation down-regulates ⊣ | ELAVL1 | 23115237 | SIGNOR-276422 |
| CHEK2 | phosphorylation up-regulates → | ELAVL1 PThr118 | phosphorylation down-regulates ⊣ | ELAVL1 | 21745814 | SIGNOR-278162 |
| PRKCD | phosphorylation up-regulates → | ELAVL1 PSer318 | phosphorylation up-regulates → | ELAVL1 | 20086103 | SIGNOR-163528 |
| CHEK2 | phosphorylation up-regulates → | ELAVL1 PSer100 | phosphorylation up-regulates → | ELAVL1 | 21745814 | SIGNOR-278161 |
| PRKCD | phosphorylation up-regulates → | ELAVL1 PSer221 | phosphorylation up-regulates → | ELAVL1 | 20086103 | SIGNOR-163524 |
| MAPK14 | phosphorylation up-regulates → | ELAVL1 PThr118 | phosphorylation up-regulates → | ELAVL1 | 19528229 | SIGNOR-186135 |
| CHEK2 | phosphorylation up-regulates → | ELAVL1 PSer88 | phosphorylation down-regulates ⊣ | ELAVL1 | 21745814 | SIGNOR-278163 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → down-regulates activity | ELAVL1 | SIGNOR-279014 |
| CHUK | phosphorylation down-regulates quantity by destabilization | ELAVL1 | SIGNOR-276422 |
| MAPK15 | phosphorylation → down-regulates activity | ELAVL1 | SIGNOR-278314 |
| CHEK2 | phosphorylation → down-regulates activity | ELAVL1 | SIGNOR-278162 |
| PRKCD | phosphorylation → up-regulates | ELAVL1 | SIGNOR-163528 |
| MAPK14 | phosphorylation → up-regulates | ELAVL1 | SIGNOR-186138 |
| CHEK2 | phosphorylation → up-regulates activity | ELAVL1 | SIGNOR-278161 |
| PRKCD | phosphorylation → up-regulates | ELAVL1 | SIGNOR-163524 |
| MAPK14 | phosphorylation → up-regulates | ELAVL1 | SIGNOR-186135 |
| MAPKAPK2 | phosphorylation → up-regulates | ELAVL1 | SIGNOR-166622 |
| CHEK2 | phosphorylation → down-regulates activity | ELAVL1 | SIGNOR-278163 |