| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | ELAVL1 | Thr118 | SGLPRTMtQKDVEDM | phosphorylation up-regulates | 19528229 | SIGNOR-186135 |
| CHEK2 | ELAVL1 | Thr118 | SGLPRTMtQKDVEDM | phosphorylation down-regulates activity | 21745814 | SIGNOR-278162 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | ELAVL1 PThr118 | phosphorylation up-regulates → | ELAVL1 | 19528229 | SIGNOR-186135 |
| CHEK2 | phosphorylation up-regulates → | ELAVL1 PThr118 | phosphorylation down-regulates ⊣ | ELAVL1 | 21745814 | SIGNOR-278162 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → up-regulates | ELAVL1 | SIGNOR-186135 |
| CHEK2 | phosphorylation → down-regulates activity | ELAVL1 | SIGNOR-278162 |
