| Name | SMAD2 |
| ID | Q15796 |
| Role | substrate |
| Enzymatic Domains |
MH1 10-176 PROSITE-ProRule
MH2 274-467 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSP2 | SMAD2 | Ser250 | TGSPAELsPTTLSPV | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248298 |
| ERK1/2 | SMAD2 | Ser250 | TGSPAELsPTTLSPV | phosphorylation up-regulates | 10197981 | SIGNOR-244723 |
| MAPK3 | SMAD2 | – | phosphorylation up-regulates activity | 19115199 | SIGNOR-217613 | |
| ACVR1B | SMAD2 | – | phosphorylation up-regulates activity | 11389842 | SIGNOR-251943 | |
| MAPK1 | SMAD2 | – | phosphorylation down-regulates | 10197981 | SIGNOR-66738 | |
| MAPK3 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates activity | 12193595 | SIGNOR-227514 |
| MAPK3 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | phosphorylation up-regulates | 10197981 | SIGNOR-66767 |
| CTDSPL | SMAD2 | Ser245 | NQSMDTGsPAELSPT | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248310 |
| CTDSP2 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248297 |
| MAPK3 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates | 10197981 | SIGNOR-66775 |
| MAPK1 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 12193595 | SIGNOR-91726 |
| CDK2 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation down-regulates activity | 19201832 | SIGNOR-279678 |
| MAPK3 | SMAD2 | Ser250 | TGSPAELsPTTLSPV | phosphorylation up-regulates | 12193595 | SIGNOR-91734 |
| CTDSPL | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248312 |
| MAPK3 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | phosphorylation up-regulates | 12193595 | SIGNOR-91738 |
| TGFBR1 | SMAD2 | Ser467 | SVRCSSMs | phosphorylation up-regulates activity | 9346908 | SIGNOR-235995 |
| MAPK3 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates | 12193595 | SIGNOR-91746 |
| CTDSP1 | SMAD2 | Ser250 | TGSPAELsPTTLSPV | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248796 |
| MAPK3 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 19115199 | SIGNOR-183000 |
| PPM1A | SMAD2 | – | dephosphorylation down-regulates activity | 16751101 | SIGNOR-217628 | |
| ERK1/2 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates | 12193595 | SIGNOR-244735 |
| ERK1/2 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | phosphorylation up-regulates | 26194464 | SIGNOR-255020 |
| ERK1/2 | SMAD2 | – | phosphorylation down-regulates | 10197981 | SIGNOR-244576 | |
| MAPK3 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 12193595 | SIGNOR-91730 |
| TGFBR1 | SMAD2 | – | phosphorylation up-regulates activity | 10973958 | SIGNOR-249549 | |
| PPM1A | SMAD2 | – | dephosphorylation down-regulates | 16751101 | SIGNOR-146919 | |
| WNK1 | SMAD2 | – | phosphorylation up-regulates quantity | 28236964 | SIGNOR-280164 | |
| CTDSPL | SMAD2 | Ser250 | TGSPAELsPTTLSPV | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248311 |
| MAPK3 | SMAD2 | – | phosphorylation down-regulates | 10197981 | SIGNOR-66778 | |
| ACVR2A | SMAD2 | – | phosphorylation up-regulates activity | 34003511 | SIGNOR-279786 | |
| CTDSP1 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248795 |
| MAPK3 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates | 19115199 | SIGNOR-183004 |
| TGFBR1 | SMAD2 | Ser465 | SPSVRCSsMS | phosphorylation up-regulates activity | 9346908 | SIGNOR-236107 |
| MAPK3 | SMAD2 | Ser250 | TGSPAELsPTTLSPV | phosphorylation up-regulates | 10197981 | SIGNOR-66763 |
| MAP3K1 | SMAD2 | – | phosphorylation up-regulates activity | 10647776 | SIGNOR-279064 | |
| PIM1 | SMAD2 | – | phosphorylation up-regulates activity | 29472550 | SIGNOR-279090 | |
| MAPK1 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 12193595 | SIGNOR-91714 |
| ARAF | SMAD2 | – | phosphorylation down-regulates quantity by destabilization | 23591895 | SIGNOR-279391 | |
| MAPK3 | SMAD2 | Ser250 | TGSPAELsPTTLSPV | phosphorylation up-regulates | 19115199 | SIGNOR-182992 |
| ACVR1B | SMAD2 | – | phosphorylation up-regulates activity | 14517293 | SIGNOR-235157 | |
| MAPK1 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | phosphorylation up-regulates | 12193595 | SIGNOR-91722 |
| MAPK3 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 10197981 | SIGNOR-66759 |
| PAK4 | SMAD2 | Ser465 | SPSVRCSsMS | phosphorylation down-regulates quantity by destabilization | 23934187 | SIGNOR-279084 |
| CTDSP1 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248797 |
| ERK1/2 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | phosphorylation up-regulates | 10197981 | SIGNOR-244727 |
| MAPK3 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 19115199 | SIGNOR-182988 |
| CTDSP1 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248794 |
| MAPK3 | SMAD2 | – | phosphorylation up-regulates activity | 10197981 | SIGNOR-236067 | |
| CAMK2A | SMAD2 | Ser260 | TLSPVNHsLDLQPVT | phosphorylation down-regulates | 11027280 | SIGNOR-82974 |
| MAPK1 | SMAD2 | Ser250 | TGSPAELsPTTLSPV | phosphorylation up-regulates | 12193595 | SIGNOR-91718 |
| Gbeta | SMAD2 | – | phosphorylation up-regulates | 10197981 | SIGNOR-270065 | |
| CTDSP2 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248299 |
| CTDSP2 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248296 |
| ERK1/2 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 10197981 | SIGNOR-244719 |
| CAMK2A | SMAD2 | Ser110 | SFSEQTRsLDGRLQV | phosphorylation down-regulates | 11027280 | SIGNOR-82966 |
| MAPK11 | SMAD2 | – | phosphorylation down-regulates | 20820849 | SIGNOR-167848 | |
| PPM1A | SMAD2 | – | dephosphorylation down-regulates activity | 25026293 | SIGNOR-277034 | |
| MAPK3 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 12193595 | SIGNOR-91742 |
| MAPK3 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 10197981 | SIGNOR-66771 |
| CTDSPL | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248309 |
| ACVR2B | SMAD2 | – | phosphorylation up-regulates activity | 21966641 | SIGNOR-254984 | |
| ERK1/2 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 12193595 | SIGNOR-244731 |
| MTMR4 | SMAD2 | – | dephosphorylation down-regulates | 20061380 | SIGNOR-163031 | |
| CAMK2A | SMAD2 | Ser240 | SDQQLNQsMDTGSPA | phosphorylation down-regulates | 11027280 | SIGNOR-82970 |
| MAPK3 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | phosphorylation up-regulates | 19115199 | SIGNOR-182996 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD2 PSer250 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248298 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PSer250 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-244723 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-227514 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer255 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-66767 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD2 PSer245 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248310 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD2 PSer245 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248297 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-66775 |
| MAPK1 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91726 |
| CDK2 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation down-regulates ⊣ | SMAD2 | 19201832 | SIGNOR-279678 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer250 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91734 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD2 PSer255 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248312 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer255 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91738 |
| TGFBR1 | phosphorylation up-regulates → | SMAD2 PSer467 | phosphorylation up-regulates → | SMAD2 | 9346908 | SIGNOR-235995 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91746 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PSer250 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248796 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 19115199 | SIGNOR-183000 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-244735 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PSer255 | phosphorylation up-regulates → | SMAD2 | 26194464 | SIGNOR-255020 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91730 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD2 PSer250 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248311 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PSer245 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248795 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 19115199 | SIGNOR-183004 |
| TGFBR1 | phosphorylation up-regulates → | SMAD2 PSer465 | phosphorylation up-regulates → | SMAD2 | 9346908 | SIGNOR-236107 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer250 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-66763 |
| MAPK1 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91714 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer250 | phosphorylation up-regulates → | SMAD2 | 19115199 | SIGNOR-182992 |
| MAPK1 | phosphorylation up-regulates → | SMAD2 PSer255 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91722 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-66759 |
| PAK4 | phosphorylation up-regulates → | SMAD2 PSer465 | phosphorylation down-regulates ⊣ | SMAD2 | 23934187 | SIGNOR-279084 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PSer255 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248797 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PSer255 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-244727 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 19115199 | SIGNOR-182988 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PThr220 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248794 |
| CAMK2A | phosphorylation up-regulates → | SMAD2 PSer260 | phosphorylation down-regulates ⊣ | SMAD2 | 11027280 | SIGNOR-82974 |
| MAPK1 | phosphorylation up-regulates → | SMAD2 PSer250 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91718 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD2 PSer255 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248299 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD2 PThr220 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248296 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-244719 |
| CAMK2A | phosphorylation up-regulates → | SMAD2 PSer110 | phosphorylation down-regulates ⊣ | SMAD2 | 11027280 | SIGNOR-82966 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91742 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-66771 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD2 PThr220 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248309 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-244731 |
| CAMK2A | phosphorylation up-regulates → | SMAD2 PSer240 | phosphorylation down-regulates ⊣ | SMAD2 | 11027280 | SIGNOR-82970 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer255 | phosphorylation up-regulates → | SMAD2 | 19115199 | SIGNOR-182996 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248298 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244723 |
| MAPK3 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-217613 |
| ACVR1B | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-251943 |
| MAPK1 | phosphorylation down-regulates | SMAD2 | SIGNOR-66738 |
| MAPK3 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-227514 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-66767 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248310 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248297 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-66775 |
| MAPK1 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91726 |
| CDK2 | phosphorylation → down-regulates activity | SMAD2 | SIGNOR-279678 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91734 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248312 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91738 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-235995 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91746 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248796 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-183000 |
| PPM1A | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-217628 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244735 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-255020 |
| ERK1/2 | phosphorylation down-regulates | SMAD2 | SIGNOR-244576 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91730 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-249549 |
| PPM1A | dephosphorylation down-regulates | SMAD2 | SIGNOR-146919 |
| WNK1 | phosphorylation → up-regulates quantity | SMAD2 | SIGNOR-280164 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248311 |
| MAPK3 | phosphorylation down-regulates | SMAD2 | SIGNOR-66778 |
| ACVR2A | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-279786 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248795 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-183004 |
| TGFBR1 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-236107 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-66763 |
| MAP3K1 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-279064 |
| PIM1 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-279090 |
| MAPK1 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91714 |
| ARAF | phosphorylation down-regulates quantity by destabilization | SMAD2 | SIGNOR-279391 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-182992 |
| ACVR1B | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-235157 |
| MAPK1 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91722 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-66759 |
| PAK4 | phosphorylation down-regulates quantity by destabilization | SMAD2 | SIGNOR-279084 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248797 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244727 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-182988 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248794 |
| MAPK3 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-236067 |
| CAMK2A | phosphorylation down-regulates | SMAD2 | SIGNOR-82974 |
| MAPK1 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91718 |
| Gbeta | phosphorylation → up-regulates | SMAD2 | SIGNOR-270065 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248299 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248296 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244719 |
| CAMK2A | phosphorylation down-regulates | SMAD2 | SIGNOR-82966 |
| MAPK11 | phosphorylation down-regulates | SMAD2 | SIGNOR-167848 |
| PPM1A | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-277034 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91742 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-66771 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248309 |
| ACVR2B | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-254984 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244731 |
| MTMR4 | dephosphorylation down-regulates | SMAD2 | SIGNOR-163031 |
| CAMK2A | phosphorylation down-regulates | SMAD2 | SIGNOR-82970 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-182996 |