Summary

Name SMAD2
Full Name Mothers against decapentaplegic homolog 2
Synonyms MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2 | MADH2, MADR2
Primary ID Q15796
Links - -
Type protein
Relations 98
Pathways TGFbeta Signaling, TGFb in cancer
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png acetylation SMAD2 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates activity img/direct-activation.png acetylation SMAD2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.23
Publications: 6 Organism: Homo Sapiens
Tissue: Lung, Breast, Lung
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.23
Publications: 15 Organism: Homo Sapiens
Tissue: Lung, Lung, Breast
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2 0.14
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SMAD2 0.14
Publications: 4 Organism: Homo Sapiens
Tissue: Lung
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.62
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.23
Publications: 3 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates img/direct-activation.png binding SMAD2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD2 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deubiquitination SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD2 0.48
Publications: 2 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD2 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: HEK-293 Cell
Pathways:TGFbeta Signaling
+ down-regulates activity img/direct_inhibition.png binding SMAD2 0.54
Publications: 2 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates activity img/direct-activation.png binding SMAD4 0.76
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ up-regulates activity img/direct-activation.png binding SMAD2 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD2 0.52
Publications: 1 Organism: Homo Sapiens
Tissue: HEK-293 Cell
+ up-regulates activity img/direct-activation.png relocalization SMAD2 0.61
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates activity img/direct-activation.png binding SMAD2 0.5
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization SMAD2 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SMAD2 0.35
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding SMAD2/SMAD4 0.31
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling, TGFb in cancer
+ up-regulates img/direct-activation.png binding SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.55
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ form complex img/form-complex.png binding SMAD2/STAT3/EP300 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SMAD2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD2 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png deubiquitination SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MEF2A 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Myotube
+ up-regulates activity img/direct-activation.png binding SMAD2 0.38
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png ubiquitination SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CREB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Lung, Breast
+ up-regulates activity img/indirect-activation.png LEF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD2 0.31
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD2 0.35
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding SMURF2 0.48
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination SMAD2 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD2 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination SMAD2 0.34
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SMAD2/SMURF2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SMAD2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMAD2 0.39
Publications: 1 Organism: Homo Sapiens
Pathways:TGFbeta Signaling, TGFb in cancer
+ up-regulates img/indirect-activation.png SMAD2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png SMAD2 0.22
Publications: 1 Organism: Homo Sapiens