| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates | 19115199 | SIGNOR-183004 |
| MAPK3 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates activity | 12193595 | SIGNOR-227514 |
| MAPK3 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates | 10197981 | SIGNOR-66775 |
| CDK2 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation down-regulates activity | 19201832 | SIGNOR-279678 |
| MAPK3 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates | 12193595 | SIGNOR-91746 |
| ERK1/2 | SMAD2 | Thr8 | MSSILPFtPPVVKRL | phosphorylation up-regulates | 12193595 | SIGNOR-244735 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 19115199 | SIGNOR-183004 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-227514 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-66775 |
| CDK2 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation down-regulates ⊣ | SMAD2 | 19201832 | SIGNOR-279678 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91746 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PThr8 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-244735 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-183004 |
| MAPK3 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-227514 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-66775 |
| CDK2 | phosphorylation → down-regulates activity | SMAD2 | SIGNOR-279678 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91746 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244735 |
