| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSP1 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248794 |
| CTDSP2 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248296 |
| MAPK3 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 12193595 | SIGNOR-91742 |
| MAPK3 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 10197981 | SIGNOR-66771 |
| CTDSPL | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248309 |
| ERK1/2 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 12193595 | SIGNOR-244731 |
| MAPK1 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 12193595 | SIGNOR-91726 |
| MAPK3 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | phosphorylation up-regulates | 19115199 | SIGNOR-183000 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PThr220 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248794 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD2 PThr220 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248296 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91742 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-66771 |
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD2 PThr220 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248309 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-244731 |
| MAPK1 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91726 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PThr220 | phosphorylation up-regulates → | SMAD2 | 19115199 | SIGNOR-183000 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248794 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248296 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91742 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-66771 |
| CTDSPL | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248309 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244731 |
| MAPK1 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91726 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-183000 |
