| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSPL | SMAD2 | Ser245 | NQSMDTGsPAELSPT | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248310 |
| CTDSP2 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248297 |
| MAPK3 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 12193595 | SIGNOR-91730 |
| CTDSP1 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248795 |
| MAPK1 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 12193595 | SIGNOR-91714 |
| MAPK3 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 10197981 | SIGNOR-66759 |
| MAPK3 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 19115199 | SIGNOR-182988 |
| ERK1/2 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | phosphorylation up-regulates | 10197981 | SIGNOR-244719 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSPL | dephosphorylation down-regulates ⊣ | SMAD2 PSer245 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248310 |
| CTDSP2 | dephosphorylation down-regulates ⊣ | SMAD2 PSer245 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248297 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91730 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PSer245 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248795 |
| MAPK1 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 12193595 | SIGNOR-91714 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-66759 |
| MAPK3 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 19115199 | SIGNOR-182988 |
| ERK1/2 | phosphorylation up-regulates → | SMAD2 PSer245 | phosphorylation up-regulates → | SMAD2 | 10197981 | SIGNOR-244719 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CTDSPL | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248310 |
| CTDSP2 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248297 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91730 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248795 |
| MAPK1 | phosphorylation → up-regulates | SMAD2 | SIGNOR-91714 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-66759 |
| MAPK3 | phosphorylation → up-regulates | SMAD2 | SIGNOR-182988 |
| ERK1/2 | phosphorylation → up-regulates | SMAD2 | SIGNOR-244719 |
