Entity Details

Name PAK4_Ser465
ID Q15796
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
TGFBR1SMAD2Ser465SPSVRCSsMSphosphorylation
up-regulates activity		9346908SIGNOR-236107
PAK4SMAD2Ser465SPSVRCSsMSphosphorylation
down-regulates quantity by destabilization		23934187SIGNOR-279084
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
TGFBR1phosphorylation
up-regulates
→
SMAD2
PSer465		phosphorylation
up-regulates
→		SMAD29346908SIGNOR-236107
PAK4phosphorylation
up-regulates
→
SMAD2
PSer465		phosphorylation
down-regulates
⊣		SMAD223934187SIGNOR-279084
Regulator Mechanism/Effect Target SIGNOR-ID
TGFBR1phosphorylation
→
up-regulates activity 		SMAD2SIGNOR-236107
PAK4phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		SMAD2SIGNOR-279084