| Name | STK11 |
| ID | Q15831 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 49-309 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | PTEN | Thr383 | HYRYSDTtDSDPENE | phosphorylation down-regulates activity | 18321849 | SIGNOR-161126 |
| STK11 | TP53 | Ser15 | PSVEPPLsQETFSDL | phosphorylation up-regulates | 17108107 | SIGNOR-150830 |
| STK11 | YAP1 | – | phosphorylation down-regulates activity | 23027127 | SIGNOR-280139 | |
| STK11 | GSK3B | – | phosphorylation down-regulates activity | 21272562 | SIGNOR-280148 | |
| STK11 | MARK1 | Thr215 | TVGNKLDtFCGSPPY | phosphorylation up-regulates | 14976552 | SIGNOR-122545 |
| STK11 | MELK | Thr167 | NKDYHLQtCCGSLAY | phosphorylation up-regulates | 16216881 | SIGNOR-141038 |
| STK11 | F2R | – | phosphorylation up-regulates activity | 23271647 | SIGNOR-278992 | |
| STK11 | SNRK | Thr173 | QPGKKLTtSCGSLAY | phosphorylation up-regulates activity | 15733851 | SIGNOR-247493 |
| STK11 | AMPK | – | phosphorylation up-regulates activity | 14976552 | SIGNOR-242602 | |
| STK11 | PRKAA2 | Thr172 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 14614828 | SIGNOR-119179 |
| STK11 | CDKN1A | Thr80 | LPKLYLPtGPRRGRD | phosphorylation down-regulates activity | 25329316 | SIGNOR-278253 |
| STK11 | NUAK2 | Thr208 | HQGKFLQtFCGSPLY | phosphorylation up-regulates | 14976552 | SIGNOR-122717 |
| STK11 | STRADA | Thr419 | SGIFGLVtNLEELEV | phosphorylation up-regulates activity | 12805220 | SIGNOR-247564 |
| STK11 | STK11 | Thr363 | IEDDIIYtQDFTVPG | phosphorylation up-regulates activity | 12805220 | SIGNOR-101848 |
| STK11 | PAK1 | Thr109 | QWARLLQtSNITKSE | phosphorylation down-regulates | 20400510 | SIGNOR-164814 |
| STK11 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates | 17108107 | SIGNOR-150834 |
| STK11 | PRKAA1 | Thr183 | SDGEFLRtSCGSPNY | phosphorylation up-regulates activity | 16054095 | SIGNOR-139297 |
| STK11 | PTEN | Ser380 | EPDHYRYsDTTDSDP | phosphorylation down-regulates activity | 21779440 | SIGNOR-161118 |
| STK11 | MARK2 | – | phosphorylation up-regulates | 17573348 | SIGNOR-156126 | |
| STK11 | SIK2 | Thr175 | KSGELLAtWCGSPPY | phosphorylation up-regulates | 14976552 | SIGNOR-122788 |
| STK11 | SIRT1 | Ser615 | GEKNERTsVAGTVRK | phosphorylation up-regulates activity | 34216621 | SIGNOR-277322 |
| STK11 | AMPK | – | phosphorylation up-regulates | 14614828 | SIGNOR-217469 | |
| STK11 | STK11 | Thr336 | KDRWRSMtVVPYLED | phosphorylation up-regulates activity | 12805220 | SIGNOR-101844 |
| STK11 | SIK3 | Thr221 | TPGQLLKtWCGSPPY | phosphorylation up-regulates | 14976552 | SIGNOR-122835 |
| STK11 | PRMT5 | Thr144 | VLTNHIHtGHHSSMF | phosphorylation up-regulates activity | 30289978 | SIGNOR-277412 |
| STK11 | STRADA | Thr329 | GLSDSLTtSTPRPSN | phosphorylation up-regulates activity | 12805220 | SIGNOR-261950 |
| STK11 | MARK4 | Thr214 | TLGSKLDtFCGSPPY | phosphorylation up-regulates | 14976552 | SIGNOR-122682 |
| STK11 | PRKAA2 | Thr172 | SDGEFLRtSCGSPNY | phosphorylation up-regulates | 14976552 | SIGNOR-122725 |
| STK11 | SIRT1 | Ser732 | EAINEAIsVKQEVTD | phosphorylation up-regulates activity | 34216621 | SIGNOR-277323 |
| STK11 | SIRT1 | Ser669 | EDDVLSSsSCGSNSD | phosphorylation up-regulates activity | 34216621 | SIGNOR-277321 |
| STK11 | NUAK1 | Thr211 | QKDKFLQtFCGSPLY | phosphorylation up-regulates | 14976552 | SIGNOR-122686 |
| STK11 | PRMT5 | Thr139 | TNLARVLtNHIHTGH | phosphorylation up-regulates activity | 30289978 | SIGNOR-277411 |
| STK11 | PRKAA1 | Thr183 | SDGEFLRtSCGSPNY | phosphorylation up-regulates activity | 14976552 | SIGNOR-122721 |
| STK11 | STK11 | Thr185 | KPGNLLLtTGGTLKI | phosphorylation up-regulates activity | 12805220 | SIGNOR-101840 |
| STK11 | BRSK1 | Thr189 | VGDSLLEtSCGSPHY | phosphorylation up-regulates | 14976552 | SIGNOR-122413 |
| STK11 | BRSK2 | Thr174 | VGDSLLEtSCGSPHY | phosphorylation up-regulates | 14976552 | SIGNOR-122485 |
| STK11 | STK11 | Thr189 | LLLTTGGtLKISDLG | phosphorylation down-regulates activity | 11430832 | SIGNOR-109028 |
| STK11 | ETV4 | – | phosphorylation down-regulates quantity by destabilization | 16912160 | SIGNOR-279293 | |
| STK11 | STK11 | Thr402 | TEAAQLStKSRAEGR | phosphorylation up-regulates activity | 12805220 | SIGNOR-101852 |
| STK11 | AMPK | – | phosphorylation up-regulates | 14976552 | SIGNOR-217472 | |
| STK11 | MARK2 | Thr208 | TFGNKLDtFCGSPPY | phosphorylation up-regulates | 14976552 | SIGNOR-122628 |
| STK11 | MARK3 | Ser215 | KLDTFCGsPPYAAPE | phosphorylation up-regulates activity | 12879020 | SIGNOR-104059 |
| STK11 | SIK1 | Thr182 | KSGEPLStWCGSPPY | phosphorylation up-regulates | 14976552 | SIGNOR-122784 |
| STK11 | SIK1 | Thr182 | KSGEPLStWCGSPPY | phosphorylation up-regulates activity | 18946175 | SIGNOR-262844 |
| STK11 | PTEN | Thr382 | DHYRYSDtTDSDPEN | phosphorylation down-regulates activity | 21779440 | SIGNOR-161122 |
| STK11 | SIRT1 | – | phosphorylation up-regulates activity | 34216621 | SIGNOR-279573 | |
| STK11 | MARK3 | Thr211 | TVGGKLDtFCGSPPY | phosphorylation up-regulates activity | 12879020 | SIGNOR-104063 |
| STK11 | MARK2 | Thr208 | TFGNKLDtFCGSPPY | phosphorylation up-regulates activity | 18424437 | SIGNOR-276165 |
| STK11 | SMAD4 | Thr77 | KCVTIQRtLDGRLQV | phosphorylation down-regulates activity | 20974850 | SIGNOR-278193 |
| STK11 | PTEN | Ser385 | RYSDTTDsDPENEPF | phosphorylation unknown | 15987703 | SIGNOR-247446 |
| STK11 | SNRK | Thr173 | QPGKKLTtSCGSLAY | phosphorylation up-regulates activity | 15733851 | SIGNOR-260824 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | phosphorylation up-regulates → | PTEN PThr383 | phosphorylation down-regulates ⊣ | PTEN | 18321849 | SIGNOR-161126 |
| STK11 | phosphorylation up-regulates → | TP53 PSer15 | phosphorylation up-regulates → | TP53 | 17108107 | SIGNOR-150830 |
| STK11 | phosphorylation up-regulates → | MARK1 PThr215 | phosphorylation up-regulates → | MARK1 | 14976552 | SIGNOR-122545 |
| STK11 | phosphorylation up-regulates → | MELK PThr167 | phosphorylation up-regulates → | MELK | 16216881 | SIGNOR-141038 |
| STK11 | phosphorylation up-regulates → | SNRK PThr173 | phosphorylation up-regulates → | SNRK | 15733851 | SIGNOR-247493 |
| STK11 | phosphorylation up-regulates → | PRKAA2 PThr172 | phosphorylation up-regulates → | PRKAA2 | 14614828 | SIGNOR-119179 |
| STK11 | phosphorylation up-regulates → | CDKN1A PThr80 | phosphorylation down-regulates ⊣ | CDKN1A | 25329316 | SIGNOR-278253 |
| STK11 | phosphorylation up-regulates → | NUAK2 PThr208 | phosphorylation up-regulates → | NUAK2 | 14976552 | SIGNOR-122717 |
| STK11 | phosphorylation up-regulates → | STRADA PThr419 | phosphorylation up-regulates → | STRADA | 12805220 | SIGNOR-247564 |
| STK11 | phosphorylation up-regulates → | STK11 PThr363 | phosphorylation up-regulates → | STK11 | 12805220 | SIGNOR-101848 |
| STK11 | phosphorylation up-regulates → | PAK1 PThr109 | phosphorylation down-regulates ⊣ | PAK1 | 20400510 | SIGNOR-164814 |
| STK11 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 17108107 | SIGNOR-150834 |
| STK11 | phosphorylation up-regulates → | PRKAA1 PThr183 | phosphorylation up-regulates → | PRKAA1 | 16054095 | SIGNOR-139297 |
| STK11 | phosphorylation up-regulates → | PTEN PSer380 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-161118 |
| STK11 | phosphorylation up-regulates → | SIK2 PThr175 | phosphorylation up-regulates → | SIK2 | 14976552 | SIGNOR-122788 |
| STK11 | phosphorylation up-regulates → | SIRT1 PSer615 | phosphorylation up-regulates → | SIRT1 | 34216621 | SIGNOR-277322 |
| STK11 | phosphorylation up-regulates → | STK11 PThr336 | phosphorylation up-regulates → | STK11 | 12805220 | SIGNOR-101844 |
| STK11 | phosphorylation up-regulates → | SIK3 PThr221 | phosphorylation up-regulates → | SIK3 | 14976552 | SIGNOR-122835 |
| STK11 | phosphorylation up-regulates → | PRMT5 PThr144 | phosphorylation up-regulates → | PRMT5 | 30289978 | SIGNOR-277412 |
| STK11 | phosphorylation up-regulates → | STRADA PThr329 | phosphorylation up-regulates → | STRADA | 12805220 | SIGNOR-261950 |
| STK11 | phosphorylation up-regulates → | MARK4 PThr214 | phosphorylation up-regulates → | MARK4 | 14976552 | SIGNOR-122682 |
| STK11 | phosphorylation up-regulates → | PRKAA2 PThr172 | phosphorylation up-regulates → | PRKAA2 | 14976552 | SIGNOR-122725 |
| STK11 | phosphorylation up-regulates → | SIRT1 PSer732 | phosphorylation up-regulates → | SIRT1 | 34216621 | SIGNOR-277323 |
| STK11 | phosphorylation up-regulates → | SIRT1 PSer669 | phosphorylation up-regulates → | SIRT1 | 34216621 | SIGNOR-277321 |
| STK11 | phosphorylation up-regulates → | NUAK1 PThr211 | phosphorylation up-regulates → | NUAK1 | 14976552 | SIGNOR-122686 |
| STK11 | phosphorylation up-regulates → | PRMT5 PThr139 | phosphorylation up-regulates → | PRMT5 | 30289978 | SIGNOR-277411 |
| STK11 | phosphorylation up-regulates → | PRKAA1 PThr183 | phosphorylation up-regulates → | PRKAA1 | 14976552 | SIGNOR-122721 |
| STK11 | phosphorylation up-regulates → | STK11 PThr185 | phosphorylation up-regulates → | STK11 | 12805220 | SIGNOR-101840 |
| STK11 | phosphorylation up-regulates → | BRSK1 PThr189 | phosphorylation up-regulates → | BRSK1 | 14976552 | SIGNOR-122413 |
| STK11 | phosphorylation up-regulates → | BRSK2 PThr174 | phosphorylation up-regulates → | BRSK2 | 14976552 | SIGNOR-122485 |
| STK11 | phosphorylation up-regulates → | STK11 PThr189 | phosphorylation down-regulates ⊣ | STK11 | 11430832 | SIGNOR-109028 |
| STK11 | phosphorylation up-regulates → | STK11 PThr402 | phosphorylation up-regulates → | STK11 | 12805220 | SIGNOR-101852 |
| STK11 | phosphorylation up-regulates → | MARK2 PThr208 | phosphorylation up-regulates → | MARK2 | 14976552 | SIGNOR-122628 |
| STK11 | phosphorylation up-regulates → | MARK3 PSer215 | phosphorylation up-regulates → | MARK3 | 12879020 | SIGNOR-104059 |
| STK11 | phosphorylation up-regulates → | SIK1 PThr182 | phosphorylation up-regulates → | SIK1 | 14976552 | SIGNOR-122784 |
| STK11 | phosphorylation up-regulates → | SIK1 PThr182 | phosphorylation up-regulates → | SIK1 | 18946175 | SIGNOR-262844 |
| STK11 | phosphorylation up-regulates → | PTEN PThr382 | phosphorylation down-regulates ⊣ | PTEN | 21779440 | SIGNOR-161122 |
| STK11 | phosphorylation up-regulates → | MARK3 PThr211 | phosphorylation up-regulates → | MARK3 | 12879020 | SIGNOR-104063 |
| STK11 | phosphorylation up-regulates → | MARK2 PThr208 | phosphorylation up-regulates → | MARK2 | 18424437 | SIGNOR-276165 |
| STK11 | phosphorylation up-regulates → | SMAD4 PThr77 | phosphorylation down-regulates ⊣ | SMAD4 | 20974850 | SIGNOR-278193 |
| STK11 | phosphorylation up-regulates → | PTEN PSer385 | phosphorylation down-regulates ⊣ | PTEN | 15987703 | SIGNOR-247446 |
| STK11 | phosphorylation up-regulates → | SNRK PThr173 | phosphorylation up-regulates → | SNRK | 15733851 | SIGNOR-260824 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK11 | phosphorylation → down-regulates activity | PTEN | SIGNOR-161126 |
| STK11 | phosphorylation → up-regulates | TP53 | SIGNOR-150830 |
| STK11 | phosphorylation → down-regulates activity | YAP1 | SIGNOR-280139 |
| STK11 | phosphorylation → down-regulates activity | GSK3B | SIGNOR-280148 |
| STK11 | phosphorylation → up-regulates | MARK1 | SIGNOR-122545 |
| STK11 | phosphorylation → up-regulates | MELK | SIGNOR-141038 |
| STK11 | phosphorylation → up-regulates activity | F2R | SIGNOR-278992 |
| STK11 | phosphorylation → up-regulates activity | SNRK | SIGNOR-247493 |
| STK11 | phosphorylation → up-regulates activity | AMPK | SIGNOR-242602 |
| STK11 | phosphorylation → up-regulates | PRKAA2 | SIGNOR-119179 |
| STK11 | phosphorylation → down-regulates activity | CDKN1A | SIGNOR-278253 |
| STK11 | phosphorylation → up-regulates | NUAK2 | SIGNOR-122717 |
| STK11 | phosphorylation → up-regulates activity | STRADA | SIGNOR-247564 |
| STK11 | phosphorylation → up-regulates activity | STK11 | SIGNOR-101848 |
| STK11 | phosphorylation down-regulates | PAK1 | SIGNOR-164814 |
| STK11 | phosphorylation → up-regulates | TP53 | SIGNOR-150834 |
| STK11 | phosphorylation → up-regulates activity | PRKAA1 | SIGNOR-139297 |
| STK11 | phosphorylation → down-regulates activity | PTEN | SIGNOR-161118 |
| STK11 | phosphorylation → up-regulates | MARK2 | SIGNOR-156126 |
| STK11 | phosphorylation → up-regulates | SIK2 | SIGNOR-122788 |
| STK11 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-277322 |
| STK11 | phosphorylation → up-regulates | AMPK | SIGNOR-217469 |
| STK11 | phosphorylation → up-regulates activity | STK11 | SIGNOR-101844 |
| STK11 | phosphorylation → up-regulates | SIK3 | SIGNOR-122835 |
| STK11 | phosphorylation → up-regulates activity | PRMT5 | SIGNOR-277412 |
| STK11 | phosphorylation → up-regulates activity | STRADA | SIGNOR-261950 |
| STK11 | phosphorylation → up-regulates | MARK4 | SIGNOR-122682 |
| STK11 | phosphorylation → up-regulates | PRKAA2 | SIGNOR-122725 |
| STK11 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-277323 |
| STK11 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-277321 |
| STK11 | phosphorylation → up-regulates | NUAK1 | SIGNOR-122686 |
| STK11 | phosphorylation → up-regulates activity | PRMT5 | SIGNOR-277411 |
| STK11 | phosphorylation → up-regulates activity | PRKAA1 | SIGNOR-122721 |
| STK11 | phosphorylation → up-regulates activity | STK11 | SIGNOR-101840 |
| STK11 | phosphorylation → up-regulates | BRSK1 | SIGNOR-122413 |
| STK11 | phosphorylation → up-regulates | BRSK2 | SIGNOR-122485 |
| STK11 | phosphorylation → down-regulates activity | STK11 | SIGNOR-109028 |
| STK11 | phosphorylation down-regulates quantity by destabilization | ETV4 | SIGNOR-279293 |
| STK11 | phosphorylation → up-regulates activity | STK11 | SIGNOR-101852 |
| STK11 | phosphorylation → up-regulates | AMPK | SIGNOR-217472 |
| STK11 | phosphorylation → up-regulates | MARK2 | SIGNOR-122628 |
| STK11 | phosphorylation → up-regulates activity | MARK3 | SIGNOR-104059 |
| STK11 | phosphorylation → up-regulates | SIK1 | SIGNOR-122784 |
| STK11 | phosphorylation → up-regulates activity | SIK1 | SIGNOR-262844 |
| STK11 | phosphorylation → down-regulates activity | PTEN | SIGNOR-161122 |
| STK11 | phosphorylation → up-regulates activity | SIRT1 | SIGNOR-279573 |
| STK11 | phosphorylation → up-regulates activity | MARK3 | SIGNOR-104063 |
| STK11 | phosphorylation → up-regulates activity | MARK2 | SIGNOR-276165 |
| STK11 | phosphorylation → down-regulates activity | SMAD4 | SIGNOR-278193 |
| STK11 | phosphorylation → unknown | PTEN | SIGNOR-247446 |
| STK11 | phosphorylation → up-regulates activity | SNRK | SIGNOR-260824 |