Summary

Name STK11
Full Name Serine/threonine-protein kinase STK11
Synonyms Liver kinase B1, LKB1, hLKB1, Renal carcinoma antigen NY-REN-19 | LKB1, PJS
Primary ID Q15831
Links - -
Type protein
Relations 49
Pathways AMPK Signaling
Function Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TP53 0.56
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MARK3 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STK11 0.37
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Smooth Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.44
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTEN 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STK11 0.14
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ down-regulates img/direct_inhibition.png phosphorylation PAK1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SIK3 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MELK 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKAA2 0.48
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SNRK 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRSK2 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SIK2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SIK1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PRKAA1 0.42
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation STK11 0.14
Publications: 4 Organism: Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates img/direct-activation.png phosphorylation BRSK1 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation STK11 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Intestinal Epithelium
Pathways:AMPK Signaling
+ up-regulates img/direct-activation.png phosphorylation MARK2 0.28
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NUAK2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NUAK1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MARK4 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MARK1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STRADA 0.39
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation STK11 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STK11 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png GSK3B 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation STK11 0.14
Publications: 1
Pathways:AMPK Signaling
+ up-regulates img/direct-activation.png phosphorylation AMPK 0.28
Publications: 2 Organism: In Vitro, Homo Sapiens
Pathways:AMPK Signaling
+ up-regulates img/direct-activation.png binding STK11 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation AMPK 0.28
Publications: 1 Organism: In Vitro
Pathways:AMPK Signaling