| Name | STK11 |
| ID | Q15831 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 49-309 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | STK11 | Thr336 | KDRWRSMtVVPYLED | phosphorylation up-regulates activity | 12805220 | SIGNOR-101844 |
| ATM | STK11 | Thr367 | IIYTQDFtVPGQVPE | phosphorylation up-regulates | 12234250 | SIGNOR-92873 |
| RPS6KA1 | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-209871 |
| STK11 | STK11 | Thr185 | KPGNLLLtTGGTLKI | phosphorylation up-regulates activity | 12805220 | SIGNOR-101840 |
| RPS6K | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-252805 |
| FYN | STK11 | Tyr261 | PFEGDNIyKLFENIG | phosphorylation down-regulates activity | 20142099 | SIGNOR-278477 |
| STK11 | STK11 | Thr189 | LLLTTGGtLKISDLG | phosphorylation down-regulates activity | 11430832 | SIGNOR-109028 |
| MAPK1 | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-209876 |
| STK11 | STK11 | Thr402 | TEAAQLStKSRAEGR | phosphorylation up-regulates activity | 12805220 | SIGNOR-101852 |
| MAPK3 | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-209880 |
| ERK1/2 | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-244595 |
| PRKCZ | STK11 | Ser307 | IRQIRQHsWFRKKHP | phosphorylation up-regulates | 19414597 | SIGNOR-185640 |
| STRADA | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation up-regulates quantity | 17482549 | SIGNOR-280149 |
| PRKACA | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation up-regulates activity | 11297520 | SIGNOR-250055 |
| ATM | STK11 | Thr363 | IEDDIIYtQDFTVPG | phosphorylation unknown | 12234250 | SIGNOR-92877 |
| STK11 | STK11 | Thr363 | IEDDIIYtQDFTVPG | phosphorylation up-regulates activity | 12805220 | SIGNOR-101848 |
| Gbeta | STK11 | – | phosphorylation down-regulates activity | 25846811 | SIGNOR-270071 | |
| PRKCZ | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation up-regulates activity | 18250273 | SIGNOR-160681 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| STK11 | phosphorylation up-regulates → | STK11 PThr336 | phosphorylation up-regulates → | STK11 | 12805220 | SIGNOR-101844 |
| ATM | phosphorylation up-regulates → | STK11 PThr367 | phosphorylation up-regulates → | STK11 | 12234250 | SIGNOR-92873 |
| RPS6KA1 | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-209871 |
| STK11 | phosphorylation up-regulates → | STK11 PThr185 | phosphorylation up-regulates → | STK11 | 12805220 | SIGNOR-101840 |
| RPS6K | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-252805 |
| FYN | phosphorylation up-regulates → | STK11 PTyr261 | phosphorylation down-regulates ⊣ | STK11 | 20142099 | SIGNOR-278477 |
| STK11 | phosphorylation up-regulates → | STK11 PThr189 | phosphorylation down-regulates ⊣ | STK11 | 11430832 | SIGNOR-109028 |
| MAPK1 | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-209876 |
| STK11 | phosphorylation up-regulates → | STK11 PThr402 | phosphorylation up-regulates → | STK11 | 12805220 | SIGNOR-101852 |
| MAPK3 | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-209880 |
| ERK1/2 | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-244595 |
| PRKCZ | phosphorylation up-regulates → | STK11 PSer307 | phosphorylation up-regulates → | STK11 | 19414597 | SIGNOR-185640 |
| STRADA | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation up-regulates → | STK11 | 17482549 | SIGNOR-280149 |
| PRKACA | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation up-regulates → | STK11 | 11297520 | SIGNOR-250055 |
| ATM | phosphorylation up-regulates → | STK11 PThr363 | phosphorylation down-regulates ⊣ | STK11 | 12234250 | SIGNOR-92877 |
| STK11 | phosphorylation up-regulates → | STK11 PThr363 | phosphorylation up-regulates → | STK11 | 12805220 | SIGNOR-101848 |
| PRKCZ | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation up-regulates → | STK11 | 18250273 | SIGNOR-160681 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| STK11 | phosphorylation → up-regulates activity | STK11 | SIGNOR-101844 |
| ATM | phosphorylation → up-regulates | STK11 | SIGNOR-92873 |
| RPS6KA1 | phosphorylation → down-regulates activity | STK11 | SIGNOR-209871 |
| STK11 | phosphorylation → up-regulates activity | STK11 | SIGNOR-101840 |
| RPS6K | phosphorylation → down-regulates activity | STK11 | SIGNOR-252805 |
| FYN | phosphorylation → down-regulates activity | STK11 | SIGNOR-278477 |
| STK11 | phosphorylation → down-regulates activity | STK11 | SIGNOR-109028 |
| MAPK1 | phosphorylation → down-regulates activity | STK11 | SIGNOR-209876 |
| STK11 | phosphorylation → up-regulates activity | STK11 | SIGNOR-101852 |
| MAPK3 | phosphorylation → down-regulates activity | STK11 | SIGNOR-209880 |
| ERK1/2 | phosphorylation → down-regulates activity | STK11 | SIGNOR-244595 |
| PRKCZ | phosphorylation → up-regulates | STK11 | SIGNOR-185640 |
| STRADA | phosphorylation → up-regulates quantity | STK11 | SIGNOR-280149 |
| PRKACA | phosphorylation → up-regulates activity | STK11 | SIGNOR-250055 |
| ATM | phosphorylation → unknown | STK11 | SIGNOR-92877 |
| STK11 | phosphorylation → up-regulates activity | STK11 | SIGNOR-101848 |
| Gbeta | phosphorylation → down-regulates activity | STK11 | SIGNOR-270071 |
| PRKCZ | phosphorylation → up-regulates activity | STK11 | SIGNOR-160681 |