| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-252805 |
| MAPK1 | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-209876 |
| MAPK3 | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-209880 |
| ERK1/2 | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-244595 |
| STRADA | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation up-regulates quantity | 17482549 | SIGNOR-280149 |
| PRKACA | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation up-regulates activity | 11297520 | SIGNOR-250055 |
| PRKCZ | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation up-regulates activity | 18250273 | SIGNOR-160681 |
| RPS6KA1 | STK11 | Ser428 | SSKIRRLsACKQQ | phosphorylation down-regulates activity | 25846811 | SIGNOR-209871 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6K | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-252805 |
| MAPK1 | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-209876 |
| MAPK3 | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-209880 |
| ERK1/2 | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-244595 |
| STRADA | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation up-regulates → | STK11 | 17482549 | SIGNOR-280149 |
| PRKACA | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation up-regulates → | STK11 | 11297520 | SIGNOR-250055 |
| PRKCZ | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation up-regulates → | STK11 | 18250273 | SIGNOR-160681 |
| RPS6KA1 | phosphorylation up-regulates → | STK11 PSer428 | phosphorylation down-regulates ⊣ | STK11 | 25846811 | SIGNOR-209871 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6K | phosphorylation → down-regulates activity | STK11 | SIGNOR-252805 |
| MAPK1 | phosphorylation → down-regulates activity | STK11 | SIGNOR-209876 |
| MAPK3 | phosphorylation → down-regulates activity | STK11 | SIGNOR-209880 |
| ERK1/2 | phosphorylation → down-regulates activity | STK11 | SIGNOR-244595 |
| STRADA | phosphorylation → up-regulates quantity | STK11 | SIGNOR-280149 |
| PRKACA | phosphorylation → up-regulates activity | STK11 | SIGNOR-250055 |
| PRKCZ | phosphorylation → up-regulates activity | STK11 | SIGNOR-160681 |
| RPS6KA1 | phosphorylation → down-regulates activity | STK11 | SIGNOR-209871 |
