Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
GSK3B	EZH2	Thr367 View in OncoXplorer	NNSSRPStPTINVLE	phosphorylation down-regulates activity	27494834	SIGNOR-278175
MELK	EZH2	Ser220	RPPRKFPsDKIFEAI	phosphorylation up-regulates quantity by stabilization	31434700	SIGNOR-277480
MAPK14	EZH2	Thr367 View in OncoXplorer	NNSSRPStPTINVLE	phosphorylation down-regulates quantity by destabilization	28067271	SIGNOR-255663
ATM	EZH2	Ser729	LFFDYRYsQADALKY	phosphorylation down-regulates quantity by destabilization	24162653	SIGNOR-276602
ATM	EZH2	Ser734	S-->L	phosphorylation down-regulates quantity	24162653	SIGNOR-279586
CDK1	EZH2	Thr345 View in OncoXplorer	LTAERIKtPPKRPGG	phosphorylation down-regulates	21659531	SIGNOR-174054
AKT1	EZH2	Ser21	CWRKRVKsEYMRLRQ	phosphorylation down-regulates activity	16224021	SIGNOR-141043
JAK2	EZH2	Tyr641	KNEFISEyCGEIISQ	phosphorylation down-regulates	24469040	SIGNOR-202711
CDK20	EZH2	–		phosphorylation up-regulates activity	25500144	SIGNOR-279017
GSK3B	EZH2	Ser363 View in OncoXplorer	GRLPNNSsRPSTPTI	phosphorylation down-regulates activity	27494834	SIGNOR-278176
MAPK14	EZH2	–		phosphorylation up-regulates activity	21902831	SIGNOR-176548
AKT	EZH2	Ser21	CWRKRVKsEYMRLRQ	phosphorylation down-regulates activity	16224021	SIGNOR-244259
CDK2	EZH2	Thr416	EANSRCQtPIKMKPN	phosphorylation up-regulates activity	23241245	SIGNOR-255656
CDK1	EZH2	Thr487 View in OncoXplorer	APAEDVDtPPRKKKR	phosphorylation down-regulates	21659531	SIGNOR-174058
JAK3	EZH2	Tyr244	AEELKEKyKELTEQQ	phosphorylation up-regulates activity	28868240	SIGNOR-278518

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
GSK3B	phosphorylation up-regulates →	EZH2 PThr367	phosphorylation down-regulates ⊣	EZH2	27494834	SIGNOR-278175
MELK	phosphorylation up-regulates →	EZH2 PSer220	phosphorylation up-regulates →	EZH2	31434700	SIGNOR-277480
MAPK14	phosphorylation up-regulates →	EZH2 PThr367	phosphorylation down-regulates ⊣	EZH2	28067271	SIGNOR-255663
ATM	phosphorylation up-regulates →	EZH2 PSer729	phosphorylation down-regulates ⊣	EZH2	24162653	SIGNOR-276602
ATM	phosphorylation up-regulates →	EZH2 PSer734	phosphorylation down-regulates ⊣	EZH2	24162653	SIGNOR-279586
CDK1	phosphorylation up-regulates →	EZH2 PThr345	phosphorylation down-regulates ⊣	EZH2	21659531	SIGNOR-174054
AKT1	phosphorylation up-regulates →	EZH2 PSer21	phosphorylation down-regulates ⊣	EZH2	16224021	SIGNOR-141043
JAK2	phosphorylation up-regulates →	EZH2 PTyr641	phosphorylation down-regulates ⊣	EZH2	24469040	SIGNOR-202711
GSK3B	phosphorylation up-regulates →	EZH2 PSer363	phosphorylation down-regulates ⊣	EZH2	27494834	SIGNOR-278176
AKT	phosphorylation up-regulates →	EZH2 PSer21	phosphorylation down-regulates ⊣	EZH2	16224021	SIGNOR-244259
CDK2	phosphorylation up-regulates →	EZH2 PThr416	phosphorylation up-regulates →	EZH2	23241245	SIGNOR-255656
CDK1	phosphorylation up-regulates →	EZH2 PThr487	phosphorylation down-regulates ⊣	EZH2	21659531	SIGNOR-174058
JAK3	phosphorylation up-regulates →	EZH2 PTyr244	phosphorylation up-regulates →	EZH2	28868240	SIGNOR-278518

Regulator	Mechanism/Effect	Target	SIGNOR-ID
GSK3B	phosphorylation → down-regulates activity	EZH2	SIGNOR-278175
MELK	phosphorylation → up-regulates quantity by stabilization	EZH2	SIGNOR-277480
MAPK14	phosphorylation down-regulates quantity by destabilization	EZH2	SIGNOR-255663
ATM	phosphorylation down-regulates quantity by destabilization	EZH2	SIGNOR-276602
ATM	phosphorylation → down-regulates quantity	EZH2	SIGNOR-279586
CDK1	phosphorylation down-regulates	EZH2	SIGNOR-174054
AKT1	phosphorylation → down-regulates activity	EZH2	SIGNOR-141043
JAK2	phosphorylation down-regulates	EZH2	SIGNOR-202711
CDK20	phosphorylation → up-regulates activity	EZH2	SIGNOR-279017
GSK3B	phosphorylation → down-regulates activity	EZH2	SIGNOR-278176
MAPK14	phosphorylation → up-regulates activity	EZH2	SIGNOR-176548
AKT	phosphorylation → down-regulates activity	EZH2	SIGNOR-244259
CDK2	phosphorylation → up-regulates activity	EZH2	SIGNOR-255656
CDK1	phosphorylation down-regulates	EZH2	SIGNOR-174058
JAK3	phosphorylation → up-regulates activity	EZH2	SIGNOR-278518