| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | EZH2 | Tyr641 | KNEFISEyCGEIISQ | phosphorylation down-regulates | 24469040 | SIGNOR-202711 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| JAK2 | phosphorylation up-regulates → | EZH2 PTyr641 | phosphorylation down-regulates ⊣ | EZH2 | 24469040 | SIGNOR-202711 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| JAK2 | phosphorylation down-regulates | EZH2 | SIGNOR-202711 |
