| Name | MAPK14 |
| ID | Q16539 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 24-308 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K3 | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates activity | 8622669 | SIGNOR-40353 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 17548358 | SIGNOR-155381 |
| MAP2K4 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 7535770 | SIGNOR-27973 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 7535770 | SIGNOR-28059 |
| FYN | MAPK14 | Tyr323 | DEPVADPyDQSFESR | phosphorylation up-regulates activity | 15735648 | SIGNOR-276031 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 17548358 | SIGNOR-155377 |
| DUSP5 | MAPK14 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-166574 | |
| DUSP1 | MAPK14 | – | dephosphorylation down-regulates activity | 17158101 | SIGNOR-236867 | |
| MAP2K6 | MAPK14 | – | phosphorylation up-regulates activity | 20551513 | SIGNOR-255780 | |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 7535770 | SIGNOR-28063 |
| MAP2K6 | MAPK14 | – | phosphorylation up-regulates activity | 8974401 | SIGNOR-236116 | |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 17126298 | SIGNOR-150879 |
| PTPN7 | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | dephosphorylation down-regulates activity | 10206983 | SIGNOR-248485 |
| DUSP9 | MAPK14 | – | dephosphorylation down-regulates | 11988087 | SIGNOR-87150 | |
| MAP2K3 | MAPK14 | – | phosphorylation up-regulates activity | 7535770 | SIGNOR-236103 | |
| MAP3K6 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-260915 |
| DUSP16 | MAPK14 | – | dephosphorylation down-regulates | 11359773 | SIGNOR-108233 | |
| FYN | MAPK14 | Tyr323 | DEPVADPyDQSFESR | phosphorylation up-regulates | 15735648 | SIGNOR-134293 |
| MAP2K6 | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates activity | 8622669 | SIGNOR-40427 |
| TLR4 | MAPK14 | – | phosphorylation up-regulates activity | 28137827 | SIGNOR-263652 | |
| MAP3K6 | MAPK14 | Tyr182 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-260916 |
| DUSP10 | MAPK14 | – | dephosphorylation down-regulates | 10391943 | SIGNOR-68983 | |
| DUSP1 | MAPK14 | – | dephosphorylation down-regulates activity | 12356755 | SIGNOR-93873 | |
| PKN1 | MAPK14 | – | phosphorylation up-regulates | 17251915 | SIGNOR-152765 | |
| DUSP7 | MAPK14 | – | dephosphorylation down-regulates | 20626350 | SIGNOR-166577 | |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 8622669 | SIGNOR-40493 |
| MAP2K6 | MAPK14 | – | phosphorylation up-regulates activity | 10480932 | SIGNOR-70607 | |
| DUSP4 | MAPK14 | – | dephosphorylation down-regulates | 16849326 | SIGNOR-147958 | |
| GRK2 | MAPK14 | Thr123 | IVKCQKLtDDHVQFL | phosphorylation down-regulates | 17055984 | SIGNOR-150152 |
| MAP2K3 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-40349 |
| PPM1D | MAPK14 | – | dephosphorylation down-regulates activity | 11101524 | SIGNOR-84793 | |
| DUSP2 | MAPK14 | – | dephosphorylation down-regulates | 8626452 | SIGNOR-40918 | |
| MAP2K4 | MAPK14 | – | phosphorylation up-regulates activity | 7839144 | SIGNOR-34121 | |
| ZAP70 | MAPK14 | – | phosphorylation up-regulates activity | 29440413 | SIGNOR-277385 | |
| MAP2K6 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-40423 |
| MAP2K3 | MAPK14 | – | phosphorylation up-regulates activity | 7839144 | SIGNOR-232156 | |
| PTPN1 | MAPK14 | – | dephosphorylation down-regulates activity | 24590766 | SIGNOR-277167 | |
| DUSP1 | MAPK14 | – | dephosphorylation down-regulates activity | 20626350 | SIGNOR-166571 | |
| MAP2K3 | MAPK14 | – | phosphorylation up-regulates activity | 8622669 | SIGNOR-40356 | |
| ZAP70 | MAPK14 | Tyr323 | DEPVADPyDQSFESR | phosphorylation up-regulates activity | 15735648 | SIGNOR-276030 |
| DUSP8 | MAPK14 | – | dephosphorylation down-regulates | 23159405 | SIGNOR-199695 | |
| PPM1D | MAPK14 | – | dephosphorylation down-regulates activity | 19713933 | SIGNOR-187770 | |
| PPM1A | MAPK14 | – | dephosphorylation down-regulates activity | 9707433 | SIGNOR-59618 | |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 17126298 | SIGNOR-150875 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 8622669 | SIGNOR-40497 |
| PTPRR | MAPK14 | – | dephosphorylation down-regulates | 11711538 | SIGNOR-111762 | |
| LCK | MAPK14 | Tyr323 | DEPVADPyDQSFESR | phosphorylation up-regulates activity | 15735648 | SIGNOR-276029 |
| ZAP70 | MAPK14 | Tyr323 | DEPVADPyDQSFESR | phosphorylation up-regulates activity | 15735648 | SIGNOR-134329 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K3 | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40353 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 17548358 | SIGNOR-155381 |
| MAP2K4 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 7535770 | SIGNOR-27973 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 7535770 | SIGNOR-28059 |
| FYN | phosphorylation up-regulates → | MAPK14 PTyr323 | phosphorylation up-regulates → | MAPK14 | 15735648 | SIGNOR-276031 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 17548358 | SIGNOR-155377 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 7535770 | SIGNOR-28063 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 17126298 | SIGNOR-150879 |
| PTPN7 | dephosphorylation down-regulates ⊣ | MAPK14 PTyr182 | dephosphorylation up-regulates → | MAPK14 | 10206983 | SIGNOR-248485 |
| MAP3K6 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-260915 |
| FYN | phosphorylation up-regulates → | MAPK14 PTyr323 | phosphorylation up-regulates → | MAPK14 | 15735648 | SIGNOR-134293 |
| MAP2K6 | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40427 |
| MAP3K6 | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-260916 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40493 |
| GRK2 | phosphorylation up-regulates → | MAPK14 PThr123 | phosphorylation down-regulates ⊣ | MAPK14 | 17055984 | SIGNOR-150152 |
| MAP2K3 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40349 |
| MAP2K6 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40423 |
| ZAP70 | phosphorylation up-regulates → | MAPK14 PTyr323 | phosphorylation up-regulates → | MAPK14 | 15735648 | SIGNOR-276030 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 17126298 | SIGNOR-150875 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40497 |
| LCK | phosphorylation up-regulates → | MAPK14 PTyr323 | phosphorylation up-regulates → | MAPK14 | 15735648 | SIGNOR-276029 |
| ZAP70 | phosphorylation up-regulates → | MAPK14 PTyr323 | phosphorylation up-regulates → | MAPK14 | 15735648 | SIGNOR-134329 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40353 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-155381 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-27973 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-28059 |
| FYN | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-276031 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-155377 |
| DUSP5 | dephosphorylation down-regulates | MAPK14 | SIGNOR-166574 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-236867 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-255780 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-28063 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-236116 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-150879 |
| PTPN7 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-248485 |
| DUSP9 | dephosphorylation down-regulates | MAPK14 | SIGNOR-87150 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-236103 |
| MAP3K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-260915 |
| DUSP16 | dephosphorylation down-regulates | MAPK14 | SIGNOR-108233 |
| FYN | phosphorylation → up-regulates | MAPK14 | SIGNOR-134293 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40427 |
| TLR4 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-263652 |
| MAP3K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-260916 |
| DUSP10 | dephosphorylation down-regulates | MAPK14 | SIGNOR-68983 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-93873 |
| PKN1 | phosphorylation → up-regulates | MAPK14 | SIGNOR-152765 |
| DUSP7 | dephosphorylation down-regulates | MAPK14 | SIGNOR-166577 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-40493 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-70607 |
| DUSP4 | dephosphorylation down-regulates | MAPK14 | SIGNOR-147958 |
| GRK2 | phosphorylation down-regulates | MAPK14 | SIGNOR-150152 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40349 |
| PPM1D | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-84793 |
| DUSP2 | dephosphorylation down-regulates | MAPK14 | SIGNOR-40918 |
| MAP2K4 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-34121 |
| ZAP70 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-277385 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40423 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-232156 |
| PTPN1 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-277167 |
| DUSP1 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-166571 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40356 |
| ZAP70 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-276030 |
| DUSP8 | dephosphorylation down-regulates | MAPK14 | SIGNOR-199695 |
| PPM1D | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-187770 |
| PPM1A | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-59618 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-150875 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-40497 |
| PTPRR | dephosphorylation down-regulates | MAPK14 | SIGNOR-111762 |
| LCK | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-276029 |
| ZAP70 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-134329 |