| + |
MAPK14 |
phosphorylation
|
H3C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166602 |
Ser11 |
TKQTARKsTGGKAPR |
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
The p38 mapk pathway can positevely regulate nf-kb activity by different mechanisms, including chromatin remodelling through ser10 phosphorylation of histone h3 at nf-kb dependent promoters such as il-8 and mcp or by impinging on ikk or the p65 subunit in a direct or indirect manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity 
phosphorylation
|
PIAS2 |
0.316 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262948 |
Ser113 |
STSVTPHsPSSPVGS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16713578 |
The switch between the coactivating and inhibitory actions of PIASxα is controlled, at least in part, through PIASxα phosphorylation. PIASxα is itself phosphorylated by p38 in vitro and in vivo in response to the activation of stress signaling pathways (Figure 2, Figure 3, Figure 4). We identify Ser113 and Ser 116 as two residues that are phosphorylated by p38 and have important functional roles |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262949 |
Ser116 |
VTPHSPSsPVGSVLL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16713578 |
The switch between the coactivating and inhibitory actions of PIASxα is controlled, at least in part, through PIASxα phosphorylation. PIASxα is itself phosphorylated by p38 in vitro and in vivo in response to the activation of stress signaling pathways (Figure 2, Figure 3, Figure 4). We identify Ser113 and Ser 116 as two residues that are phosphorylated by p38 and have important functional roles |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
ESR1 |
0.627 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-136950 |
Ser118 |
LHPPPQLsPFLQPHG |
Homo sapiens |
|
| pmid |
sentence |
| 15879307 |
Conversely, constitutively active mkk6 induced p38 mapk activation that recapitulated the effects of polyphenols by inducing eralpha phosphorylation and downstream activation of akt, and enos. The key role of eralpha ser-118 phosphorylation was confirmed in enos-transfected cos-7 cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90823 |
Thr311 |
NSLALSLtADQMVSA |
Homo sapiens |
|
| pmid |
sentence |
| 12138194 |
P38 mitogen-activated protein kinase was involved in estrogen receptor activation by estrogens and mekk1. Here, we report estrogen receptor-dependent p38 activation by estrogens in endometrial adenocarcinoma cells and in vitro and in vivo phosphorylation of the estrogen receptor alpha mediated through p38. The phosphorylation site was identified as threonine-311 (thr(311)), located in helix 1 of the hormone-binding domain. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates quantity by stabilization
phosphorylation
|
CDKN1A |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89436 |
Ser130 |
SGEQAEGsPGGPGDS |
Homo sapiens |
|
| pmid |
sentence |
| 12058028 |
The stress-activated protein kinases p38 alpha and jnk1 stabilize p21(cip1) by phosphorylation.|p38 alpha and JNK1 phosphorylated p21 in vivo, and both p38 alpha and JNK1 phosphorylated p21 at Ser(130) in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
TCF3 |
0.483 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134194 |
Ser139 |
LNSPGPLsPSGMKGT |
Homo sapiens |
|
| pmid |
sentence |
| 15719023 |
Here we show that p38 mapk, whose activity is essential for myogenesis, regulates myod/e47 heterodimerization. Phosphorylation of e47 at ser140 by p38 induces myod/e47 association and activation of muscle-specific transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAPK14 | up-regulates quantity by stabilization
phosphorylation
|
TP53 |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226614 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
JB6 Cl41 Cell |
| pmid |
sentence |
| 10781582 |
Serine 15 phosphorylation of p53 leads to a stabilization of p53 by reducing its interaction with murine double minute 2, a negative regulatory partner[...]These results strongly suggest that both ERKs and p38 kinase have a direct role in UVB-induced phosphorylation of p53 at serine 15 in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, P38 Signaling |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
TP53 |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72695 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 10581258 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72699 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 10581258 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250114 |
Ser392 |
FKTEGPDsD |
|
|
| pmid |
sentence |
| 10747897 |
We demonstrate that anisomycin- and tumor necrosis factor--induced phosphorylation of p53 at Ser-392, which is important for the transcriptional activity of this growth suppressor protein, requires p38 MAP kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72703 |
Ser46 |
AMDDLMLsPDDIEQW |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 10581258 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226620 |
Ser46 |
AMDDLMLsPDDIEQW |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15642743 |
Recombinant p38 phosphorylated recombinant p53 on serine 46 in vitro. Inhibition of p38 MAPK by pharmacological inhibitors, dominant-negative p38, or small interfering RNA, suppressed p53S46P |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155246 |
Ser46 |
AMDDLMLsPDDIEQW |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 17535811 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens, |
| Pathways: | FLT3-ITD signaling, P38 Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
TP53 |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105737 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 11258706 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192057 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 22975381 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155242 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 17535811 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105741 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 11258706 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, P38 Signaling |
| + |
MAPK14 | down-regulates 
phosphorylation
|
CASP3 |
0.777 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122099 |
Ser150 |
FRGDRCRsLTGKPKL |
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 14970175 |
Consequently, p38-mapk can directly phosphorylate and inhibit the activities of caspase-8 and caspase-3 and thereby hinder neutrophil apoptosis, and, in so doing, regulate the inflammatory response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TNF-alpha Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
BAZ1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188160 |
Ser158 |
KSDGACDsPSSDKEN |
Homo sapiens |
|
| pmid |
sentence |
| 19776015 |
Moreover, this region (wac domain) was also phosphorylated by recombinant proteins of p38_? And jnk2_? But not by akt1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
PAK6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130979 |
Ser165 |
MPWPEPQsPRVLPNG |
Homo sapiens |
|
| pmid |
sentence |
| 15550393 |
The activation of pak6 by both p38 map kinase and mkk6 suggests that pak6 plays a role in the cellular response to stress-related signals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
NFATC4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250107 |
Ser168 |
QGGGAFFsPSPGSSS |
Cricetulus griseus |
BHK Cell |
| pmid |
sentence |
| 11997522 |
P38 MAP kinase phosphorylates Ser168 and Ser170 of NFATc4. Mutational replacement of Ser168,170 with Ala promotes NFATc4 nuclear localization and increases NFATc4-mediated transcription activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250108 |
Ser170 |
GGAFFSPsPGSSSLS |
Cricetulus griseus |
BHK Cell |
| pmid |
sentence |
| 11997522 |
P38 MAP kinase phosphorylates Ser168 and Ser170 of NFATc4. Mutational replacement of Ser168,170 with Ala promotes NFATc4 nuclear localization and increases NFATc4-mediated transcription activity. |
|
| Publications: |
2 |
Organism: |
Cricetulus Griseus |
| + |
MAPK14 | down-regulates
phosphorylation
|
NFATC1 |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74560 |
Ser172 |
YRDPSCLsPASSLSS |
Homo sapiens |
|
| pmid |
sentence |
| 10652349 |
We show that jnk, erk, and p38 physically associate with the nfatc n-terminal regulatory domain and can directly phosphorylate functionally important residues involved in regulating nfatc subcellular localization, namely ser(172) and the conserved nfatc ser-pro repeats. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
RPS6KA4 |
0.604 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77204 |
Ser196 |
EEKERTFsFCGTIEY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77208 |
Ser343 |
TRLEPVYsPPGSPPP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77212 |
Ser347 |
PVYSPPGsPPPGDPR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77216 |
Ser360 |
PRIFQGYsFVAPSIL |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77220 |
Thr568 |
SPGVPMQtPCFTLQY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60995 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9792677 |
Rsk-b is a p38alphamapk substrate, and activated by p38alphamapk and, more weakly, by erk1 |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
SMAD3 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250113 |
Ser204 |
NHSMDAGsPNLSPNP |
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 15520018 |
Smad3 was phosphorylated at both Ser203 and Ser207 in untreated MCF10CA1h cells and the p38 and ROCK inhibitors each down-regulated phosphorylation at these sites. we demonstrate that phosphorylation at Ser203 and Ser207 residues is required for the full transactivation potential of Smad3, and that these residues are targets of the p38 and Rho/ROCK pathways. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250112 |
Ser208 |
DAGSPNLsPNPMSPA |
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 15520018 |
Smad3 was phosphorylated at both Ser203 and Ser207 in untreated MCF10CA1h cells and the p38 and ROCK inhibitors each down-regulated phosphorylation at these sites. we demonstrate that phosphorylation at Ser203 and Ser207 residues is required for the full transactivation potential of Smad3, and that these residues are targets of the p38 and Rho/ROCK pathways. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236136 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 14512875 |
P38 mapk mediates fibrogenic signal through smad3 phosphorylation in rat myofibroblasts. the phosphorylation promoted hetero-complex formation and nuclear translocation of smad3 and smad4. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Rattus Norvegicus |
| Pathways: | TGF-beta Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
NR3C1 |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255952 |
Ser211 |
PGKETNEsPWRSDLL |
Mus musculus |
|
| pmid |
sentence |
| 20660302 |
We demonstrate here that AMPK differentially modulates glucocorticoid action by phosphorylating the human GR at serine 211 indirectly through the activation of p38 MAPK |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135198 |
Ser211 |
PGKETNEsPWRSDLL |
Homo sapiens |
|
| pmid |
sentence |
| 15817653 |
We found serine 211 of the human gr to be a substrate for p38 mapk both in vitro and intracellularly. Mutation of this site to alanine greatly diminished gr-driven gene transcription and apoptosis. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
RBSN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140143 |
Ser215 |
ESLSTHTsPSQSPNS |
Homo sapiens |
|
| pmid |
sentence |
| 16138080 |
We found that p38alpha can phosphorylate the rab5 effectors eea1 and rabenosyn-5 on thr-1392 and ser-215, respectively, and these phosphorylation events regulate the recruitment of eea1 and rabenosyn-5 to membranes |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140146 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16138080 |
We found that p38alpha can phosphorylate the rab5 effectors eea1 and rabenosyn-5 on thr-1392 and ser-215, respectively, and these phosphorylation events regulate the recruitment of eea1 and rabenosyn-5 to membranes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
CDC25C |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250091 |
Ser216 |
SGLYRSPsMPENLNR |
in vitro |
|
| pmid |
sentence |
| 9543386 |
P38 binds and phosphorylates Cdc25B at serines 309 and 361, and Cdc25C at serine 216; phosphorylation of these residues is required for binding to 14-3-3 proteins. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK14 | up-regulates quantity by stabilization
phosphorylation
|
FOXC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275913 |
Ser241 |
PSPPQPLsPAAALGS |
|
|
| pmid |
sentence |
| 31650548 |
P38 interacts with and phosphorylates the Ser241 and ser272 sites of FOXC1 to maintain its stability by inhibiting ubiquitination and degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275911 |
Ser272 |
SSLSSGSsPPGSLPS |
|
|
| pmid |
sentence |
| 31650548 |
P38 interacts with and phosphorylates the Ser241 and ser272 sites of FOXC1 to maintain its stability by inhibiting ubiquitination and degradation. |
|
| Publications: |
2 |
| + |
MAPK14 | up-regulates
phosphorylation
|
PPARGC1A |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112766 |
Ser266 |
SLPLTPEsPNDPKGS |
Homo sapiens |
|
| pmid |
sentence |
| 11741533 |
Cytokine stimulation of energy expenditure through p38 map kinase activation of ppargamma coactivator-1we show here that many cytokines activate the transcriptional ppar gamma coactivator-1 (pgc-1) through phosphorylation by p38 kinase, resulting in stabilization and activation of pgc-1 proteinp38 mapk directly phosphorylates pgc-1 on residues threonine 262, serine 265, and threonine 298 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112770 |
Thr263 |
TTLSLPLtPESPNDP |
Homo sapiens |
|
| pmid |
sentence |
| 11741533 |
Cytokine stimulation of energy expenditure through p38 map kinase activation of ppargamma coactivator-1we show here that many cytokines activate the transcriptional ppar gamma coactivator-1 (pgc-1) through phosphorylation by p38 kinase, resulting in stabilization and activation of pgc-1 proteinp38 mapk directly phosphorylates pgc-1 on residues threonine 262, serine 265, and threonine 298 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112774 |
Thr299 |
AGLTPPTtPPHKANQ |
Homo sapiens |
|
| pmid |
sentence |
| 11741533 |
Cytokine stimulation of energy expenditure through p38 map kinase activation of ppargamma coactivator-1we show here that many cytokines activate the transcriptional ppar gamma coactivator-1 (pgc-1) through phosphorylation by p38 kinase, resulting in stabilization and activation of pgc-1 proteinp38 mapk directly phosphorylates pgc-1 on residues threonine 262, serine 265, and threonine 298 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MAPKAPK2 |
0.768 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118036 |
Ser272 |
SNHGLAIsPGMKTRI |
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 14499342 |
Mapk-activated protein kinase-2 (mk2) is activated by p38 mapk in human neutrophils. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250101 |
Thr206 |
PNAILKLtDFGFAKE |
in vitro |
|
| pmid |
sentence |
| 7592979 |
In Vitro Activation of MAPKAP Kinase 2 by p38/40. the constitutively active mutant T205E,T317E shows no changes in activity after treatment with the p38/40 fraction |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118040 |
Thr222 |
TSHNSLTtPCYTPYY |
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 14499342 |
Mapk-activated protein kinase-2 (mk2) is activated by p38 mapk in human neutrophils. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-44351 |
Thr25 |
APPPQPPtPALPHPP |
Homo sapiens |
|
| pmid |
sentence |
| 8846784 |
Here we show that in vitro rk phosphorylates human gst-mapkap kinase-2 at thr25 in the proline-rich n-terminal region thr222 and ser272 in the catalytic domain and thr334 in the c-terminal domain. Using novel methodology we demonstrate that activation of mapkap kinase-2 requires the phosphorylation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250102 |
Thr317 |
PTQRMTItEFMNHPW |
in vitro |
|
| pmid |
sentence |
| 7592979 |
In Vitro Activation of MAPKAP Kinase 2 by p38/40. the constitutively active mutant T205E,T317E shows no changes in activity after treatment with the p38/40 fraction |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118044 |
Thr334 |
QSTKVPQtPLHTSRV |
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 14499342 |
Mapk-activated protein kinase-2 (mk2) is activated by p38 mapk in human neutrophils. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | FLT3-ITD signaling, P38 Signaling |
| + |
MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
CDX2 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250092 |
Ser283 |
RSVPEPLsPVSSLQA |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250093 |
Ser287 |
EPLSPVSsLQASVPG |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250094 |
Ser291 |
PVSSLQAsVPGSVPG |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250095 |
Ser295 |
LQASVPGsVPGVLGP |
Homo sapiens |
|
| pmid |
sentence |
| 16027724 |
ERK2, p38alpha and GSK-3beta can phosphorylate Cdx2 in vitro and that the 4S motif is required for phosphorylation by GSK-3beta and p38alpha|Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates
phosphorylation
|
F3 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199868 |
Ser290 |
GQSWKENsPLNVS |
Homo sapiens |
|
| pmid |
sentence |
| 23195225 |
We previously showed that the phosphorylation of ser253 within the cytoplasmic domain of human tissue factor (tf) initiates the incorporation and release of this protein into cell-derived microparticles. Furthermore, subsequent phosphorylation of ser258 terminates this process. Our current study has identified p38_ as a major kinase, responsible for the phosphorylation of ser258 within the cytoplasmic domain of tf |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
TP63 |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277414 |
Ser301 |
S-->T |
in vitro |
|
| pmid |
sentence |
| 30301786 |
P38α phosphorylates and destabilizes p63. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277414 |
Ser310 |
LYNFMCNsSCVGGMN |
in vitro |
|
| pmid |
sentence |
| 30301786 |
P38α phosphorylates and destabilizes p63. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
MAPK14 | down-regulates
phosphorylation
|
PIP4K2B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149359 |
Ser326 |
SYGTPPDsPGNLLSF |
Homo sapiens |
|
| pmid |
sentence |
| 16949365 |
Inhibition of pip4kbeta activity occurs through the direct phosphorylation of pip4kbeta at ser326 by the p38 stress-activated protein kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
DLX5 |
0.291 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255792 |
Ser34 |
MHHPSQEsPTLPESS |
Mus musculus |
|
| pmid |
sentence |
| 18056716 |
We show that Dlx5 is a novel substrate for p38 MAPK in vitro and in vivo and that Ser-34 and Ser-217 are the sites phosphorylated by p38 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK14 | down-regulates
phosphorylation
|
CASP8 |
0.549 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122103 |
Ser347 |
FTGLKCPsLAGKPKV |
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 14970175 |
P38-mapk can directly phosphorylate and inhibit the activities of caspase-8 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | TNF-alpha Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
ELK3 |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47681 |
Ser357 |
IHFWSSLsPVAPLSP |
Homo sapiens |
|
| pmid |
sentence |
| 9130707 |
Tcf sap-1a is efficiently phosphorylated by p38 map kinase in vitro and in vivo on the homologous residues ser381 and ser387. Mutation of these sites to alanine severely reduces c-fos sre-dependent transcription mediated by sap-1a and p38 map kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47685 |
Ser363 |
LSPVAPLsPARLQGP |
Homo sapiens |
|
| pmid |
sentence |
| 9130707 |
Tcf sap-1a is efficiently phosphorylated by p38 map kinase in vitro and in vivo on the homologous residues ser381 and ser387. Mutation of these sites to alanine severely reduces c-fos sre-dependent transcription mediated by sap-1a and p38 map kinase. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
RPS6KA5 |
0.611 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130736 |
Ser360 |
TEMDPTYsPAALPQS |
Homo sapiens |
|
| pmid |
sentence |
| 15568999 |
Msk1 (mitogen- and stress-activated protein kinase) is a kinase activated in cells downstream of both the erk1/2 (extracellular-signal-regulated kinase) and p38 mapk (mitogen-activated protein kinase) cascades. In the present study, we show that, in addition to being phosphorylated on thr-581 and ser-360 by erk1/2 or p38, msk1 can autophosphorylate on at least six sites |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249199 |
Ser376 |
EKLFQGYsFVAPSIL |
|
|
| pmid |
sentence |
| 15568999 |
In the present study, we show that, in addition to being phosphorylated on Thr-581 and Ser-360 by ERK1/2 or p38, MSK1 can autophosphorylate on at least six sites: Ser-212, Ser-376, Ser-381, Ser-750, Ser-752 and Ser-758. Of these sites, the N-terminal T-loop residue Ser-212 and the 'hydrophobic motif' Ser-376 are phosphorylated by the C-terminal kinase domain of MSK1, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain of MSK1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131375 |
Thr581 |
PDNQPLKtPCFTLHY |
Homo sapiens |
|
| pmid |
sentence |
| 15568999 |
Msk1 (mitogen- and stress-activated protein kinase) is a kinase activated in cells downstream of both the erk1/2 (extracellular-signal-regulated kinase) and p38 mapk (mitogen-activated protein kinase) cascades. In the present study, we show that, in addition to being phosphorylated on thr-581 and ser-360 by erk1/2 or p38, msk1 can autophosphorylate on at least six sites |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59454 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9687510 |
Mitogen- and stress-activated protein kinase-1 (msk1) is directly activated by mapk and sapk2/p38,. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens, |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
ELK1 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-85510 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 11145955 |
Subsequent studies with dominant negative elk-1, wild type, and variant gal4-elk-1 fusion proteins confirmed that phosphorylation of elk-1 at serines 383 and 389 in the c-terminal region of elk-1 is an important downstream target associated with activation of an sre by e2. Both e2 (er?-Dependent) and growth factors (er?-Independent) activated the sre in breast cancer cells via the ras/mapk pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167539 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20727996 |
Elk-1 is a member of the e-twenty-six (ets) domain superfamily of transcription factors and has been traditionally associated with mitogen-induced immediate early gene transcription upon phosphorylation by mitogen activated protein kinases (erk/mapk). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47630 |
Ser383 |
IHFWSTLsPIAPRSP |
Homo sapiens |
|
| pmid |
sentence |
| 9130707 |
We demonstrate here that elk-1 is barely activated by a third subclass of map kinases (p38), most likely because the critical residues ser383 and ser389 are poorly phosphorylated by p38 map kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47634 |
Ser389 |
LSPIAPRsPAKLSFQ |
Homo sapiens |
|
| pmid |
sentence |
| 9130707 |
We demonstrate here that elk-1 is barely activated by a third subclass of map kinases (p38), most likely because the critical residues ser383 and ser389 are poorly phosphorylated by p38 map kinase. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MEF2C |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62788 |
Ser387 |
LSLPSTQsLNIKSEP |
Homo sapiens |
|
| pmid |
sentence |
| 9858528 |
Our studies showed that p38 specifically phosphorylates serine 387 and threonines 293 and 300 within the mef2c transactivation domain |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-47136 |
Thr293 |
QSAQSLAtPVVSVAT |
Homo sapiens |
|
| pmid |
sentence |
| 9069290 |
We found that in monocytic cells, lps increases the transactivation activity of mef2c through p38-catalysed phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62792 |
Thr293 |
QSAQSLAtPVVSVAT |
Homo sapiens |
|
| pmid |
sentence |
| 9858528 |
Our studies showed that p38 specifically phosphorylates serine 387 and threonines 293 and 300 within the mef2c transactivation domain |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62796 |
Thr300 |
TPVVSVAtPTLPGQG |
Homo sapiens |
|
| pmid |
sentence |
| 9858528 |
Our studies showed that p38 specifically phosphorylates serine 387 and threonines 293 and 300 within the mef2c transactivation domain |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
As a permissive environment is created at these loci, p38 further stimulates gene expression through the phosphorylation of additional myogenic transcription factors, including mef2c and e47. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis |
| + |
MAPK14 | down-regulates
phosphorylation
|
GSK3B |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157548 |
Ser389 |
ARIQAAAsTPTNATA |
Homo sapiens |
|
| pmid |
sentence |
| 17726008 |
However p38alfa also inactivates gsk3b by direct phosphorilation of the c-terminal residue ser389. this non-canonicl p38 mapk-dependent phosphorilation of gsk3b seems to occur primarily in the brain and thymocytes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178603 |
Ser389 |
ARIQAAAsTPTNATA |
Homo sapiens |
|
| pmid |
sentence |
| 18451303 |
Here, we show that p38 mitogen-activated protein kinase (mapk) also inactivates gsk3beta by direct phosphorylation at its c terminus, and this inactivation can lead to an accumulation of beta-catenin. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| Pathways: | FLT3-ITD signaling |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
EEF2K |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249707 |
Ser396 |
TFDSLPSsPSSATPH |
in vitro |
|
| pmid |
sentence |
| 12171600 |
Inhibition of eEF2 kinase resulting from phosphorylation of Ser-396 by SAPK2a p38 was approx.25%. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK14 | up-regulates
phosphorylation
|
HBP1 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119138 |
Ser402 |
GFSKNCGsPGSSQLS |
Homo sapiens |
|
| pmid |
sentence |
| 14612426 |
A mutation of the p38 map kinase phosphorylation site at aa 401 [(s-a)401hbp1] also triggered hbp1 protein instability. While protein stability was compromised by mutation, the specific activities of (s-a)401hbp1 and of wild-type hbp1 appeared comparable for transcriptional repression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 |
phosphorylation
|
MEF2A |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98224 |
Ser408 |
SIKSEPIsPPRDRMT |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12586839 |
A p38 mapk-induced phosphopeptide with no mapk consensus the phosphorylation site is identified as ser-408 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98228 |
Ser453 |
PRQEMGRsPVDSLSS |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12586839 |
Thr-312 and thr-319 are known phosphorylation sites important for the increased transcriptional activation of mef2a by p38 mapk. Ser-453 and ser-479 are phosphorylated in vitro but were not important functionally |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
TAB1 |
0.825 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185580 |
Ser423 |
QMVNGAHsASTLDEA |
Homo sapiens |
|
| pmid |
sentence |
| 19393267 |
Egfr-mediated phosphorylation of tab1 was completely inhibited by a chemical inhibitor and sirna of p38alpha. The phosphorylation of tab1 was occurred at ser-423 and thr-431, the residues underlying the p38-mediated feedback inhibition of tak1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118922 |
Ser438 |
TPTLTNQsPTLTLQS |
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 14592977 |
Tab1, a subunit of the kinase tak1, was phosphorylated by sapk2a/p38alpha at ser423, thr431 and ser438 in vitro. the results presented here also show that sapk2a/p38? Suppresses the activity of tak1 in cells, because the activation of tak1 by proinflammatory cytokines and lps is enhanced if cells are first pre?incubated With sb 203580 or in cells that do not express sapk2a/p38?. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185584 |
Thr431 |
ASTLDEAtPTLTNQS |
Homo sapiens |
|
| pmid |
sentence |
| 19393267 |
Egfr-mediated phosphorylation of tab1 was completely inhibited by a chemical inhibitor and sirna of p38alpha. The phosphorylation of tab1 was occurred at ser-423 and thr-431, the residues underlying the p38-mediated feedback inhibition of tak1. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates activity 
phosphorylation
|
AKT2 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-91408 |
Ser474 |
RTHFPQFsYSASIRE |
Homo sapiens |
|
| pmid |
sentence |
| 12181443 |
We show [] that the kinase activity and s473 phosphorylation of akt induced by lpa and s1p requires both mitogen-activated protein (map) kinase kinase (mek) and p38 map kinase. [] among different stimuli tested, platelet-derived growth factor stimulates s473 phosphorylation of akt in a mek- and p38-dependent manner. However, epidermal growth factor, thrombin, and endothelin-1?stimulated Akt s473 phosphorylation require p38 but not mek. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
PLA2G4A |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-44673 |
Ser505 |
LNTSYPLsPLSDFAT |
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 8910365 |
These results provide the first direct evidence that p38 kinase is responsible for cpla2 phosphorylation in sfllrn-stimulated platelets and is involved in the early phosphorylation of cpla2 in thrombin-stimulated platelets |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
NCOA3 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250103 |
Ser505 |
SPVAGVHsPMASSGN |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15383283 |
P38 MAPK and JNK can phosphorylate multiple sites on SRC-3, including S505, S543, S860, and S867. Our results suggest that several kinases are important for phosphorylating SRC-3 and enhancing its interaction with DNA-dependent transcription factors and other coactivators. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250104 |
Ser543 |
SLLSTLSsPGPKLDN |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15383283 |
P38 MAPK and JNK can phosphorylate multiple sites on SRC-3, including S505, S543, S860, and S867. Our results suggest that several kinases are important for phosphorylating SRC-3 and enhancing its interaction with DNA-dependent transcription factors and other coactivators. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250105 |
Ser860 |
NRAVSLDsPVSVGSS |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15383283 |
P38 MAPK and JNK can phosphorylate multiple sites on SRC-3, including S505, S543, S860, and S867. Our results suggest that several kinases are important for phosphorylating SRC-3 and enhancing its interaction with DNA-dependent transcription factors and other coactivators. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250106 |
Ser867 |
SPVSVGSsPPVKNIS |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 15383283 |
P38 MAPK and JNK can phosphorylate multiple sites on SRC-3, including S505, S543, S860, and S867. Our results suggest that several kinases are important for phosphorylating SRC-3 and enhancing its interaction with DNA-dependent transcription factors and other coactivators. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
SNX27 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279069 |
Ser51 |
VRIVKSEsGYGFNVR |
Homo sapiens |
|
| pmid |
sentence |
| 33605979 |
Altogether, our study suggests that MAPK11 and MAPK14 mediate the phosphorylation of SNX27 at Ser51 in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
USP21 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273670 |
Ser538 |
VYNDSRVsPVSENQV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 28254948 |
In this study, we found that USP21 is an important deubiquitinating enzyme for STING and that it negatively regulates the DNA virus-induced production of type I interferons by hydrolyzing K27/63-linked polyubiquitin chain on STING. HSV-1 infection recruited USP21 to STING at late stage by p38-mediated phosphorylation of USP21 at Ser538. I |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates
phosphorylation
|
RB1 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168178 |
Ser567 |
SLAWLSDsPLFDLIK |
Homo sapiens |
|
| pmid |
sentence |
| 20871633 |
P38 bypasses the cell cycle-associated hierarchical phosphorylation and directly phosphorylates rb on ser567, which is not phosphorylated during the normal cell cycle. Phosphorylation by p38, but not cdks, triggers an interaction between rb and the human homolog of murine double minute 2 (hdm2), leading to degradation of rb, release of e2f1 and cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
EIF4EBP1 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250097 |
Ser65 |
FLMECRNsPVTKTPP |
Homo sapiens |
JB6 Cl41 Cell |
| pmid |
sentence |
| 11777913 |
4E-BP1 Is Phosphorylated in Vitro by Active p38 Kinase. In the present study we demonstrated that UVB induced 4E-BP1 phosphorylation at multiple sites, Thr-36, Thr-45, Ser-64, and Thr-69, leading to dissociation of 4E-BP1 from eIF-4E. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250098 |
Thr37 |
PPGDYSTtPGGTLFS |
Homo sapiens |
JB6 Cl41 Cell |
| pmid |
sentence |
| 11777913 |
4E-BP1 Is Phosphorylated in Vitro by Active p38 Kinase. In the present study we demonstrated that UVB induced 4E-BP1 phosphorylation at multiple sites, Thr-36, Thr-45, Ser-64, and Thr-69, leading to dissociation of 4E-BP1 from eIF-4E. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250099 |
Thr46 |
GGTLFSTtPGGTRII |
Homo sapiens |
JB6 Cl41 Cell |
| pmid |
sentence |
| 11777913 |
4E-BP1 Is Phosphorylated in Vitro by Active p38 Kinase. In the present study we demonstrated that UVB induced 4E-BP1 phosphorylation at multiple sites, Thr-36, Thr-45, Ser-64, and Thr-69, leading to dissociation of 4E-BP1 from eIF-4E. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
TWIST1 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-173409 |
Ser68 |
GGGDEPGsPAQGKRG |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21502402 |
Phosphorylation of serine 68 of twist1 by mapks stabilizes twist1 protein and promotes breast cancer cell invasiveness. this ser 68 is phosphorylated by p38, c-jun n-terminal kinases (jnk), and extracellular signal-regulated kinases1/2 in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
BCL2L11 |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260442 |
Ser69 |
GPLAPPAsPGPFATR |
Rattus norvegicus |
|
| pmid |
sentence |
| 15486195 |
Ser69 can also be phosphorylated by JNK and p38MAPK at least in vitro. Phosphorylation of BimEL on Ser69 promotes its ubiquitination. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MAPK14 | up-regulates
phosphorylation
|
FOXO |
0.523 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252960 |
Ser7 |
sPAPLSPL |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22128155 |
Ogether, our results suggest that p38 phosphorylation of foxo3a on ser-7 is essential for its nuclear relocalization in response to doxorubicin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
FOXO3 |
0.523 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177927 |
Ser7 |
sPAPLSPL |
Homo sapiens |
|
| pmid |
sentence |
| 22128155 |
Ogether, our results suggest that p38 phosphorylation of foxo3a on ser-7 is essential for its nuclear relocalization in response to doxorubicin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
STAT4 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154787 |
Ser721 |
PSDLLPMsPSVYAVL |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
SLC9A1 |
0.571 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111039 |
Ser723 |
VITIDPAsPQSPESV |
Homo sapiens |
|
| pmid |
sentence |
| 11604491 |
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates nhe1, which induces intracellular alkalinization. activated p38 mapk directly phosphorylated the c terminus of nhe1 within a 40-amino-acid region. Analysis by mass spectroscopy identified four phosphorylation sites on nhe1, thr 717, ser 722, ser 725, and ser 728. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111043 |
Ser726 |
IDPASPQsPESVDLV |
Homo sapiens |
|
| pmid |
sentence |
| 11604491 |
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates nhe1, which induces intracellular alkalinization. activated p38 mapk directly phosphorylated the c terminus of nhe1 within a 40-amino-acid region. Analysis by mass spectroscopy identified four phosphorylation sites on nhe1, thr 717, ser 722, ser 725, and ser 728. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180044 |
Ser726 |
IDPASPQsPESVDLV |
Homo sapiens |
|
| pmid |
sentence |
| 18701649 |
Such results suggest that during apoptosis, oxidative stress could activate p38 mapk, phosphorylating nhe1 at s726 and s729. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180048 |
Ser729 |
ASPQSPEsVDLVNEE |
Homo sapiens |
|
| pmid |
sentence |
| 18701649 |
Such results suggest that during apoptosis, oxidative stress could activate p38 mapk, phosphorylating nhe1 at s726 and s729. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111047 |
Ser729 |
ASPQSPEsVDLVNEE |
Homo sapiens |
|
| pmid |
sentence |
| 11604491 |
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates nhe1, which induces intracellular alkalinization. activated p38 mapk directly phosphorylated the c terminus of nhe1 within a 40-amino-acid region. Analysis by mass spectroscopy identified four phosphorylation sites on nhe1, thr 717, ser 722, ser 725, and ser 728. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111051 |
Thr718 |
KEDLPVItIDPASPQ |
Homo sapiens |
|
| pmid |
sentence |
| 11604491 |
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates nhe1, which induces intracellular alkalinization. activated p38 mapk directly phosphorylated the c terminus of nhe1 within a 40-amino-acid region. Analysis by mass spectroscopy identified four phosphorylation sites on nhe1, thr 717, ser 722, ser 725, and ser 728. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
STAT1 |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154779 |
Ser727 |
TDNLLPMsPEEFDEV |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
STAT3 |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154783 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179912 |
Ser727 |
NTIDLPMsPRTLDSL |
Homo sapiens |
|
| pmid |
sentence |
| 18691976 |
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
KRT8 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114079 |
Ser74 |
TVNQSLLsPLVLEVD |
Homo sapiens |
|
| pmid |
sentence |
| 11788583 |
Keratin 8 (k8) serine 73 occurs within a relatively conserved type ii keratin motif ((68)nqsllspl) and becomes phosphorylated in cultured cells and organs during mitosis, cell stress, and apoptosis. Here we show that ser-73 is exclusively phosphorylated in vitro by p38 mitogen-activated protein kinase.The ser-73 --> ala-associated filament reorganization defect is rescued by a ser-73 --> asp mutation. Also, disease-causing keratin mutations can modulate keratin phosphorylation and organization, which may affect disease pathogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates
phosphorylation
|
FGFR1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166598 |
Ser777 |
SMPLDQYsPSFPDTR |
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Fgfr1 translocation requires p38 mapk activation which phosphorylates the c-term tail of fgfr1 on ser777 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
DDIT3 |
0.611 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42200 |
Ser79 |
EVTSTSQsPHSPDSS |
Homo sapiens |
|
| pmid |
sentence |
| 8650547 |
...undergoes inducible phosphorylation on two adjacent serine residues (78 and 81). In vitro, chop is phosphorylated on these residues by p38 mitogen-activated protein kinase (map kinase). phosphorylation of chop on these residues enhanced its ability to function as a transcriptional activator. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250096 |
Ser82 |
STSQSPHsPDSSQSS |
in vitro |
|
| pmid |
sentence |
| 8650547 |
CHOP, a member of the C/EBP family of transcription factors, mediates effects of cellular stress on growth and differentiation. It accumulates under conditions of stress and undergoes inducible phosphorylation on two adjacent serine residues (78 and 81). In vitro, CHOP is phosphorylated on these residues by p38 mitogen-activated protein kinase (MAP kinase). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
JUNB |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-127545 |
Ser79 |
QGSDTGAsLKLASSE |
Homo sapiens |
|
| pmid |
sentence |
| 15308641 |
These results clearly demonstrate that phosphorylation by p38 kinase is essential for the regulation of dmp1 transcription by junb and p300. phosphorylation of junb at ser-79 was found to be essential for its interaction with p300. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
EPS15 |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-203315 |
Ser796 |
RSINKLDsPDPFKLN |
Homo sapiens |
|
| pmid |
sentence |
| 24269888 |
Tnf-_ induces phosphorylation of eps15 at ser-796eps15 is a substrate for p38_these results suggest an attractive model in which p38 phosphorylates both eps15 and egfr to trigger efficient endocytosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 |
phosphorylation
|
PXN |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122108 |
Ser85 |
HQQPQSSsPVYGSSA |
Homo sapiens |
|
| pmid |
sentence |
| 14970194 |
Here, we show that paxillin is phosphorylated by p38mapk in vitro and in nerve growth factor (ngf)-induced pc-12 cells. Ser 85 (ser 83 for endogenous paxillin) is identified as one of major phosphorylation sites by phosphopeptide mapping and mass spectrometry. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
BCL2 |
0.332 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184936 |
Ser87 |
AAAGPALsPVPPVVH |
Homo sapiens |
|
| pmid |
sentence |
| 19336399 |
The protein's reduced antiapoptotic capacity was related to phosphorylation of its threonine 56 and serine 87 residues by virally activated p38mapk |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146786 |
Thr56 |
FSSQPGHtPHPAASR |
Homo sapiens |
|
| pmid |
sentence |
| 16714293 |
Bcl-2 phosphorylation by p38 mapkin this study, we identify, by using mass spectrometry techniques and specific anti-phosphopeptide antibodies, ser(87) and thr(56) as the bcl-2 residues phosphorylated by p38 mapk and show that phosphorylation of these residues is always associated with a decrease in the antiapoptotic potential of bcl-2 protein. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
ATF2 |
0.795 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250090 |
Ser90 |
GLFNELAsPFENEFK |
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 10085140 |
P38 directly phosphorylates ATF-2 at Thr-69, Thr-71, and Ser-90, resulting in stimulation of its trans-activating capacity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65593 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10085140 |
On the other hand, sapks such as jnks and p38 phosphorylate atf-2 at thr-69, thr-71, and ser-90 which lie close to the n-terminal transcriptional activation domain and stimulate itstrans-activating capacity our results indicate that atf-2 not only directly binds to smad3/4 hetero-oligomers but also that atf-2 is phosphorylated by tgf- signaling via tak1 and p38. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
PTPN7 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250109 |
Ser93 |
ALQRQPPsPKQLEEE |
in vitro |
|
| pmid |
sentence |
| 10206983 |
The noncatalytic N terminus of HePTP binds Erk and p38 and is phosphorylated at Ser-72 and Thr-45 by these kinases. the N terminus of HePTP binds Erk and p38 but may release them upon phosphorylation.it is clear that phosphorylation of HePTP at Thr-45 and/or Ser-72 is not required for inhibition of MAP kinase. Rather, it seems that phosphorylation has the opposite effect, namely to lessen the inhibitory effect of HePTP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250110 |
Thr66 |
EPICSVNtPREVTLH |
in vitro |
|
| pmid |
sentence |
| 10206983 |
The noncatalytic N terminus of HePTP binds Erk and p38 and is phosphorylated at Ser-72 and Thr-45 by these kinases. the N terminus of HePTP binds Erk and p38 but may release them upon phosphorylation.it is clear that phosphorylation of HePTP at Thr-45 and/or Ser-72 is not required for inhibition of MAP kinase. Rather, it seems that phosphorylation has the opposite effect, namely to lessen the inhibitory effect of HePTP. |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
GLI1 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277916 |
Ser937 |
FLGGSQVsPSRAKAP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 38307877 |
Here, we show that SHH inactivates p38α (MAPK14) in a smoothened-dependent manner, conversely, p38α directly phosphorylates GLI1 on Ser937/Ser941 (human/mouse) to induce GLI1's proteasomal degradation and negates the transcription of SHH signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277917 |
Ser941 |
S-->A |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 38307877 |
Here, we show that SHH inactivates p38α (MAPK14) in a smoothened-dependent manner, conversely, p38α directly phosphorylates GLI1 on Ser937/Ser941 (human/mouse) to induce GLI1's proteasomal degradation and negates the transcription of SHH signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277917 |
Ser982 |
VVGANRAsHRAAAPP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 38307877 |
Here, we show that SHH inactivates p38α (MAPK14) in a smoothened-dependent manner, conversely, p38α directly phosphorylates GLI1 on Ser937/Ser941 (human/mouse) to induce GLI1's proteasomal degradation and negates the transcription of SHH signaling. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
ZNHIT1 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153899 |
Thr103 |
AEGPNYLtACAGPPS |
Homo sapiens |
|
| pmid |
sentence |
| 17380123 |
Our results indicate that p38 mapk plays an important role in the regulation of p18hamlet half?life. In particular, p38 mapk activation is required for the accumulation of p18hamlet induced by dna damage?inducing Agents such as uv. We also showed that several sites that are phosphorylated by p38? In vitro are also important for p18hamlet protein stability in cells. the high conservation of thr103 as a phosphorylation site in p18hamlet proteins from different species (figure 1a), together with the in vitro phosphorylation experiments, suggested that this residue could be an important target for p38 mapk |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20473270 |
We show that the srcap subunit named znhit1 or p18(hamlet), which is a substrate of p38 mapk, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 mapk-dependent manner. Furthermore, p18hamlet was phosphorylated during myoblast differentiation in a p38 mapk-dependent manner (dal testo pmc) |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
ELAVL1 |
0.522 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186135 |
Thr118 |
SGLPRTMtQKDVEDM |
Homo sapiens |
|
| pmid |
sentence |
| 19528229 |
P38 mapk phosphorylates the mrna binding protein hur on thr118, which results in cytoplasmic accumulation of hur and its enhanced binding to the p21cip1 mrna. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19528229 |
P38 mapk phosphorylates the mrna binding protein hur on thr118, which results in cytoplasmic accumulation of hur and its enhanced binding to the p21cip1 mrna. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GRK2 | down-regulates
phosphorylation
|
MAPK14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150152 |
Thr123 |
IVKCQKLtDDHVQFL |
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 17055984 |
Phosphorylation of p38 by grk2 at the docking groove unveils a novel mechanism for inactivating p38mapk p38 associates with grk2 endogenously and is phosphorylated by grk2 at thr-123, a residue located at its docking groove. Mimicking phosphorylation at this site impairs the binding and activation of p38 by mkk6 and diminishes the capacity of p38 to bind and phosphorylate its substrates |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
EEA1 |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140082 |
Thr1392 |
CSAKNALtPSSKKPV |
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16138080 |
We found that p38alpha can phosphorylate the rab5 effectors eea1 and rabenosyn-5 on thr-1392 and ser-215, respectively, and these phosphorylation events regulate the recruitment of eea1 and rabenosyn-5 to membranes |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK14 |
phosphorylation
|
JDP2 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250100 |
Thr148 |
VRTDSVKtPESEGNP |
in vitro |
|
| pmid |
sentence |
| 12225289 |
Wild-type JDP2 exhibited efficient phosphorylation by the p38 kinase, the mutant JDP2 T%)A did not incorporate labelled Figure 5 JDP2 C-terminal domain is necessary but not sufficient for p38 phosphorylation (A) p38 phosphorylated JDP2 at Thr-148. Bacterially purified His-JDP2 (Wt) or His-JDP2 T148A (Ala) were incubated with bacterially purified activated p38 F327S [21] in the presence of [γ- 32P]ATP for 30 min. Proteins were resolved by SDS/PAGE (12 % gel), dried and exposed to autoradiography. (B) The JDP2 C-terminal domain is necessary but not sufficient for phosphorylation by p38 kinase. Bacterially purified GST fusion proteins with full-length JDP2 (Wt) C-terminally truncated JDP2 (∆C) and JDP2 C-terminal fragment (Dock) were used in an in vitro kinase assay as described in (A). A representative experiment is presented. (C) In vitro kinase assay using GST-JDP2 (JDP2wt), JDP2 ∆C and JDP2-Dock as substrates with either activated p38 or HA-JNK2 kinases. Protein mixtures were resolved by SDS/PAGE, fixed, dried and analysed by PhosphorImaging. The results represent meansS.E.M. from three independent experiments. phosphate in the presence of activated p38 kinase. This indicates that both p38 and JNK kinases are able to integrate stress signals to JDP2 Thr-148 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
USF1 |
0.555 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185572 |
Thr153 |
EALLGQAtPPGTGQF |
Homo sapiens |
|
| pmid |
sentence |
| 19389701 |
Following uv irradiation, usf-1 is phosphorylated by the p38 stress-activated kinase on threonine 153 and directly up-regulates expression of the pomc, mc1r, tyr, tyrp-1 and dct genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
KAT5 |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278958 |
Thr158 |
VEVVSPAtPVPSETA |
Homo sapiens |
|
| pmid |
sentence |
| 25544752 |
We found that phosphorylation of Tip60-T158 was increased by p38\u03b1 isolated from Dox- or \u03b3-radiation-treated cells over that from untreated cells (Figure xref ), indicating that DNA damage induces the protein kinase activity of p38\u03b1 towards Tip60-T158. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
TP53BP1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264446 |
Thr1609 |
LGPYEAVtPLTKAAD |
in vitro |
|
| pmid |
sentence |
| 24703952 |
Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif.|Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks |phosphorylation of T1609 is likely to be mediated by p38 MAPK |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
ATF6 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276841 |
Thr166 |
NKTENGLtPKKKIQV |
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 25135476 |
This observation not only confirms the specific role for IFN-γ-induced p38 MAPK-dependent phosphorylation of ATF6 at the T166 site but also indicates a connection between phosphorylation and proteolytic activation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RET | up-regulates
phosphorylation
|
MAPK14 |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40493 |
Thr180 |
RHTDDEMtGYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 8622669 |
Dually phosphorylated on thr-180 and tyr-182 by the map2ks map2k3/mkk3, map2k4/mkk4 and map2k6/mkk6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155377 |
Thr180 |
RHTDDEMtGYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 17548358 |
Dually phosphorylated on thr-180 and tyr-182 by the map2ks map2k3/mkk3, map2k4/mkk4 and map2k6/mkk6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150875 |
Thr180 |
RHTDDEMtGYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 17126298 |
Dually phosphorylated on thr-180 and tyr-182 by the map2ks map2k3/mkk3, map2k4/mkk4 and map2k6/mkk6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-28059 |
Thr180 |
RHTDDEMtGYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 7535770 |
Dually phosphorylated on thr-180 and tyr-182 by the map2ks map2k3/mkk3, map2k4/mkk4 and map2k6/mkk6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150879 |
Tyr182 |
TDDEMTGyVATRWYR |
Homo sapiens |
|
| pmid |
sentence |
| 17126298 |
Dually phosphorylated on thr-180 and tyr-182 by the map2ks map2k3/mkk3, map2k4/mkk4 and map2k6/mkk6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40497 |
Tyr182 |
TDDEMTGyVATRWYR |
Homo sapiens |
|
| pmid |
sentence |
| 8622669 |
Dually phosphorylated on thr-180 and tyr-182 by the map2ks map2k3/mkk3, map2k4/mkk4 and map2k6/mkk6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-28063 |
Tyr182 |
TDDEMTGyVATRWYR |
Homo sapiens |
|
| pmid |
sentence |
| 7535770 |
Dually phosphorylated on thr-180 and tyr-182 by the map2ks map2k3/mkk3, map2k4/mkk4 and map2k6/mkk6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155381 |
Tyr182 |
TDDEMTGyVATRWYR |
Homo sapiens |
|
| pmid |
sentence |
| 17548358 |
Dually phosphorylated on thr-180 and tyr-182 by the map2ks map2k3/mkk3, map2k4/mkk4 and map2k6/mkk6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. |
|
| Publications: |
8 |
Organism: |
Homo Sapiens |
| + |
MAP2K6 | up-regulates activity
phosphorylation
|
MAPK14 |
0.744 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40423 |
Thr180 |
RHTDDEMtGYVATRW |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8622669 |
These data indicate that mkk6 phosphorylates p38 map kinase on thr-180 and tyr-182, the sites of phosphorylation that activate p38 map kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40427 |
Tyr182 |
TDDEMTGyVATRWYR |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8622669 |
These data indicate that mkk6 phosphorylates p38 map kinase on thr-180 and tyr-182, the sites of phosphorylation that activate p38 map kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70607 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10480932 |
We have found that p38 mitogen-activated protein kinase, and its direct activator MKK6 are rapidly activated in response to TGF-beta. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236116 |
|
|
Homo sapiens |
COS-7 Cell |
| pmid |
sentence |
| 8974401 |
A MAP kinase kinase kinase (MAPKKK), termed ASK1, was identified that activated two different subgroups of MAP kinase kinases (MAPKK), SEK1 (or MKK4) and MKK3/MAPKK6 (or MKK6), which in turn activated stress-activated protein kinase (SAPK, also known as JNK; c-Jun amino-terminal kinase) and p38 subgroups of MAP kinases, respectively. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255780 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20551513 |
Expression of a constitutively active mutant of MKK6 (MKK6-glu) (39), but not a kinase-inactive mutant of MKK6 (MKK6-K82A) (39), strongly promoted human MSC differentiation to osteoblasts as shown by increased ALP activity and extracellular matrix mineralization (Figure 4E). Furthermore, MKK6-glu–expressing osteoblasts were treated with inhibitors of p38, JNK, and MEK (Figure 4F). Only treatment with the p38 inhibitor SB203580 blocked the effects of MKK6-glu. |
|
| Publications: |
5 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TGF-beta Signaling, Toll like receptors |
| + |
MAP2K3 | up-regulates activity
phosphorylation
|
MAPK14 |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40349 |
Thr180 |
RHTDDEMtGYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 8622669 |
Mkk3 is a protein kinase that phosphorylates and activates p38 map kinase but does not phosphorylate the related jnk or erk map kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40353 |
Tyr182 |
TDDEMTGyVATRWYR |
Homo sapiens |
|
| pmid |
sentence |
| 8622669 |
Mkk3 is a protein kinase that phosphorylates and activates p38 map kinase but does not phosphorylate the related jnk or erk map kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232156 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8622669 |
Mkk3 is a protein kinase that phosphorylates and activates p38 map kinase but does not phosphorylate the related jnk or erk map kinases. MKK3 is therefore a specific activator of p38 MAP kinase that is independent of the JNK and ERK signaling pathways. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236103 |
|
|
Homo sapiens |
Neutrophil, Macrophage, Monocyte |
| pmid |
sentence |
| 7535770 |
Recently, two map kinase kinases (mkk3 and mkk4) that activate p38 map kinase have been identified. the mechanism of p38 activation is mediated by dual phosphorylation on thr-180 and tyr-182. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling, TGF-beta Signaling, Toll like receptors |
| + |
MAP3K6 | up-regulates activity
phosphorylation
|
MAPK14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260915 |
Thr180 |
RHTDDEMtGYVATRW |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8622669 |
These data indicate that MKK6 phosphorylates p38 MAP kinase on Thr-180 and Tyr-182, the sites of phosphorylation that activate p38 MAP kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260916 |
Tyr182 |
RHTDDEMtGYVATRW |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 8622669 |
These data indicate that MKK6 phosphorylates p38 MAP kinase on Thr-180 and Tyr-182, the sites of phosphorylation that activate p38 MAP kinase |
|
| Publications: |
2 |
Organism: |
Chlorocebus Aethiops |
| + |
MAP2K4 | up-regulates activity
phosphorylation
|
MAPK14 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27973 |
Thr180 |
RHTDDEMtGYVATRW |
Homo sapiens |
|
| pmid |
sentence |
| 7535770 |
Recently, two MAP kinase kinases (MKK3 and MKK4) that activate p38 MAP kinase have been identified. The mechanism of p38 activation is mediated by dual phosphorylation on Thr-180 and Tyr-182 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34121 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7839144 |
Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling, TGF-beta Signaling |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MAPKAPK5 |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58135 |
Thr182 |
IDQGDLMtPQFTPYY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9628874 |
In hela cells, prak was activated in response to cellular stress and proinflammatory cytokines. Prak activity was regulated by p38alpha and p38beta both in vitro and in vivo and thr182 was shown to be the regulatory phosphorylation site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MKNK1 |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48342 |
Thr250 |
NSCTPITtPELTTPC |
Homo sapiens |
|
| pmid |
sentence |
| 9155017 |
Mnk1, but not mnk2, also binds strongly to the stress-activated kinase, p38. Erk and p38 phosphorylate MNK1 and Mnk2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253011 |
|
|
in vitro |
|
| pmid |
sentence |
| 9155018 |
These results indicate that MNK1 is a novel class of protein kinase that is activated through both the ERK and p38 MAP kinase signaling pathways |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| + |
MAPK14 | up-regulates
phosphorylation
|
MKNK1 |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48346 |
Thr255 |
ITTPELTtPCGSAEY |
Homo sapiens |
|
| pmid |
sentence |
| 9155017 |
Mnk1, but not mnk2, also binds strongly to the stress-activated kinase, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
ZAP70 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277384 |
Thr293 |
TLNSDGYtPEPARIT |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 29440413 |
We have found that T cell p38 MAP kinase (MAPK), which is directly phosphorylated and activated by ZAP-70 downstream of the TCR, in turn phosphorylates Thr-293 in the interdomain B region of ZAP-70. These results identify a tight negative feedback loop in which ZAP-70-activated p38 reciprocally phosphorylates ZAP-70 and destabilizes the signaling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MEF2A |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62780 |
Thr312 |
QATQPLAtPVVSVTT |
Homo sapiens |
|
| pmid |
sentence |
| 9858528 |
We show that mef2a, but not mef2b or mef2d, is a substrate for p38. Threonines 312 and 319 are the key regulatory phosphorylation sites by p38 in mef2a. Phosphorylation at these sites enhances transcriptional activity of mef2a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis |
| + |
MAPK14 | up-regulates
phosphorylation
|
MEF2A |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62784 |
Thr319 |
TPVVSVTtPSLPPQG |
Homo sapiens |
|
| pmid |
sentence |
| 9858528 |
We show that mef2a, but not mef2b or mef2d, is a substrate for p38. Threonines 312 and 319 are the key regulatory phosphorylation sites by p38 in mef2a. Phosphorylation at these sites enhances transcriptional activity of mef2a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis |
| + |
MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
RBPJ |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276403 |
Thr339 |
STDKAEYtFYEGMGP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22302987 |
P38 MAPK phosphorylates RBP-Jk at Thr339 by physical binding, which subsequently induces the degradation and ubiquitylation of the RBP-Jk protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
EZH2 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255663 |
Thr367 |
NNSSRPStPTINVLE |
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 28067271 |
Here, we show that p38α kinase promotes EZH2 degradation in differentiating muscle cells through phosphorylation of threonine 372 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAPK14 | up-regulates
phosphorylation
|
ATF2 |
0.795 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65597 |
Thr69 |
SVIVADQtPTPTRFL |
Homo sapiens |
|
| pmid |
sentence |
| 10085140 |
On the other hand, sapks such as jnks and p38 phosphorylate atf-2 at thr-69, thr-71, and ser-90 which lie close to the n-terminal transcriptional activation domain and stimulate itstrans-activating capacity our results indicate that atf-2 not only directly binds to smad3/4 hetero-oligomers but also that atf-2 is phosphorylated by tgf- signaling via tak1 and p38. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163246 |
Thr69 |
SVIVADQtPTPTRFL |
Homo sapiens |
|
| pmid |
sentence |
| 20068231 |
Phosphorylation of thr-69 by mapk14 and mapk11, and at thr-71 by mapk1/erk2, mapk3/erk1, mapk11, mapk12 and mapk14 in response to external stimulus like insulin causes increased transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90521 |
Thr69 |
SVIVADQtPTPTRFL |
Homo sapiens |
|
| pmid |
sentence |
| 12110590 |
Here, we show that in fibroblasts, insulin, epidermal growth factor (egf) and serum activate atf2 via a so far unknown two-step mechanism involving two distinct ras effector pathways: the raf-mek-erk pathway induces phosphorylation of atf2 thr71, whereas subsequent atf2 thr69 phosphorylation requires the ral-ralgds-src-p38 pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65601 |
Thr71 |
IVADQTPtPTRFLKN |
Homo sapiens |
|
| pmid |
sentence |
| 10085140 |
On the other hand, sapks such as jnks and p38 phosphorylate atf-2 at thr-69, thr-71, and ser-90 which lie close to the n-terminal transcriptional activation domain and stimulate itstrans-activating capacity our results indicate that atf-2 not only directly binds to smad3/4 hetero-oligomers but also that atf-2 is phosphorylated by tgf- signaling via tak1 and p38. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90525 |
Thr71 |
IVADQTPtPTRFLKN |
Homo sapiens |
|
| pmid |
sentence |
| 12110590 |
Here, we show that in fibroblasts, insulin, epidermal growth factor (egf) and serum activate atf2 via a so far unknown two-step mechanism involving two distinct ras effector pathways: the raf-mek-erk pathway induces phosphorylation of atf2 thr71, whereas subsequent atf2 thr69 phosphorylation requires the ral-ralgds-src-p38 pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163250 |
Thr71 |
IVADQTPtPTRFLKN |
Homo sapiens |
|
| pmid |
sentence |
| 20068231 |
Phosphorylation of thr-69 by mapk14 and mapk11, and at thr-71 by mapk1/erk2, mapk3/erk1, mapk11, mapk12 and mapk14 in response to external stimulus like insulin causes increased transcriptional activity. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| Pathways: | TGF-beta Signaling |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
KHSRP |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235856 |
Thr692 |
QAAYYGQtPGPGGPQ |
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 16364914 |
KSRP, an important factor for AU-rich element (ARE)-directed mRNA decay, undergoes p38-dependent phosphorylation during muscle differentiation. KSRP phosphorylated by p38 displays compromised binding to ARE-containing transcripts and fails to promote their rapid decay, although it retains the ability to interact with the mRNA degradation machinery |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
ADAM17 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163970 |
Thr735 |
KPFPAPQtPGRLQPA |
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 20188673 |
We show that p38 MAP kinase, which is activated in response to inflammatory or stress signals, directly activates TACE, a membrane-associated metalloprotease that is also known as ADAM17 and effects shedding in response to growth factors and Erk MAP kinase activation. p38alpha MAP kinase interacts with the cytoplasmic domain of TACE and phosphorylates it on Thr(735), which is required for TACE-mediated ectodomain shedding |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis |
| + |
MAPK14 |
phosphorylation
|
EWSR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182778 |
Thr79 |
QPPTGYTtPTAPQAY |
Homo sapiens |
|
| pmid |
sentence |
| 19076070 |
Here we report that ews and ews-fli1 become phosphorylated at thr79 . but the p38_/p38_ mapks were the major kinases phosphorylating ews-fli1. It will be important to investigate how the p38_/p38_-stimulated phosphorylation of ews-fusion proteins affects their ability to transactivate and their oncogenic potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN7 | down-regulates activity
dephosphorylation
|
MAPK14 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248485 |
Tyr182 |
TDDEMTGyVATRWYR |
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 10206983 |
In Jurkat cells, LC-PTP suppressed the ERK and p38 mitogen-activated protein kinase cascades |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZAP70 | up-regulates activity
phosphorylation
|
MAPK14 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276030 |
Tyr323 |
DEPVADPyDQSFESR |
Mus musculus |
T-lymphocyte |
| pmid |
sentence |
| 15735648 |
Lck, Fyn, and Zap70 activate p38 even in the absence of Tyr182 phosphorylation.p38 is a substrate for Fyn, Lck and Zap70.Thus, T cell Src family kinases and Zap70 activate p38 by phosphorylating Tyr323. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134329 |
Tyr323 |
DEPVADPyDQSFESR |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15735648 |
Thus, phosphorylation of tyr323 dependent on the tyrosine kinase lck and mediated by zap70 serves as an important mechanism for tcr activation of p38 in t cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277385 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 29440413 |
We have found that T cell p38 MAP kinase (MAPK), which is directly phosphorylated and activated by ZAP-70 downstream of the TCR, in turn phosphorylates Thr-293 in the interdomain B region of ZAP-70. These results identify a tight negative feedback loop in which ZAP-70-activated p38 reciprocally phosphorylates ZAP-70 and destabilizes the signaling complex. |
|
| Publications: |
3 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
FYN | up-regulates
phosphorylation
|
MAPK14 |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134293 |
Tyr323 |
DEPVADPyDQSFESR |
Homo sapiens |
|
| pmid |
sentence |
| 15735648 |
T cell src family kinases and zap70 activate p38 by phosphorylating tyr323. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LCK | up-regulates activity
phosphorylation
|
MAPK14 |
0.477 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276029 |
Tyr323 |
DEPVADPyDQSFESR |
Mus musculus |
T-lymphocyte |
| pmid |
sentence |
| 15735648 |
Lck, Fyn, and Zap70 activate p38 even in the absence of Tyr182 phosphorylation.p38 is a substrate for Fyn, Lck and Zap70.Thus, T cell Src family kinases and Zap70 activate p38 by phosphorylating Tyr323. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Glucocorticoid receptor Signaling, P38 Signaling |
| + |
FYN | up-regulates activity
phosphorylation
|
MAPK14 |
0.491 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276031 |
Tyr323 |
DEPVADPyDQSFESR |
Mus musculus |
T-lymphocyte |
| pmid |
sentence |
| 15735648 |
Lck, Fyn, and Zap70 activate p38 even in the absence of Tyr182 phosphorylation.p38 is a substrate for Fyn, Lck and Zap70.Thus, T cell Src family kinases and Zap70 activate p38 by phosphorylating Tyr323. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK14 | down-regulates activity 
|
AKT |
0.634 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244461 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
On the other hand, p38 alfa may negatively modulate akt activity, indipendently of pi3k by regulating the interaction between caveolin 1 and pp2a through a mechanism dependent on cell attachment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
VX-745 | down-regulates
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11892915 |
Vx-745 was reported to be active against several isotypes of p38 mapk, including p38alpha, p38beta and p38gamma |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | down-regulates activity
|
MAPK14 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100591 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 12697749 |
Our data indicate that akt2 inhibits cisplatin-induced jnk/p38 and bax activation through phosphorylation of ask1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
DUSP10 | down-regulates
dephosphorylation
|
MAPK14 |
0.696 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68983 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10391943 |
Mkp-5 binds to p38 and sapk/jnk, but not to mapk/erk, and inactivates p38 and sapk/jnk, but not mapk/erk. p38 is a preferred substrate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(-)-anisomycin | up-regulates
chemical activation
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189699 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates quantity by expression
transcriptional regulation
|
COL1A1 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192796 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
(tak1) and tak1 binding protein 1 (tab1) play a pivotal role as upstream sig-nal transducers by activating the mkk3-p38 mapk signaling cascade that leads to the induction of type i collagen expression by tgf-beta1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP1 | down-regulates activity
dephosphorylation
|
MAPK14 |
0.806 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93873 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 12356755 |
Here we show that glucocorticoids synergistically enhance nthi-induced tlr2 expression via specific up-regulation of the mapk phosphatase-1 (mkp-1) that, in turn, leads to dephosphorylation and inactivation of p38 mapk, the negative regulator for tlr2 expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
The activity of MAPKs can be also regulated by a family of DUSPs (dual-specificity phosphatases)/MKPs (MAPK phosphatases), which dephosphorylate both phosphotyrosine and phosphothreonine residues MKPs 1, 4, 5 and 7 can dephosphorylate p38_ and p38_ in addition to JNK MAPKs. Importantly, some MKPs are transcriptionally up-regulated by stimuli that activate MAPK signalling, and are thought to play an important role limiting the extent of MAPK activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236867 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17158101 |
Our results show that Notch specifically induces expression of MKP-1, a member of the dual-specificity MAPK phosphatase, which directly inactivates p38 to negatively regulate C2C12 myogenesis. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling |
| + |
AMPK | up-regulates activity
|
MAPK14 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255951 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20660302 |
P38 MAPK mediates the effect of AMPK on Gr induced transcriptional activity |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | FLT3-ITD signaling |
| + |
PKN1 | up-regulates
phosphorylation
|
MAPK14 |
0.376 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152765 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
At the same time, rho signals to c-jun n-terminal kinase (jnk) and p38 through rock and protein kinase n (pkn), leading to the transcriptional regulation of jun |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
transcriptional regulation
|
Fibrosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255958 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 11904165 |
These data indicate that TGF-beta1-induced p38 activation is involved in TGF-beta1-stimulated collagen synthesis. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | TGF-beta Signaling |
| + |
AKT | down-regulates activity
|
MAPK14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244288 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 12697749 |
Our data indicate that akt2 inhibits cisplatin-induced jnk/p38 and bax activation through phosphorylation of ask1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
PTPRR | down-regulates
dephosphorylation
|
MAPK14 |
0.557 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111762 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11711538 |
As shown, gst-ptp-sl dephosphorylated efficiently both erk2 and p38 wild typetogether, these results indicate that the defective association of the tyrosine phosphatase ptp-sl with erk2 d319n and p38 d316n mutations impairs the retention and inactivation in the cytosol of these map kinases by ptp-sl. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP7 | down-regulates
dephosphorylation
|
MAPK14 |
0.656 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
The activity of mapks can be also regulated by a family of dusps, which dephosphorylates bot phosphotyrosine and phopsphothreonine residues |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SB-202190 | down-regulates
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-206697 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TNFRSF1A | up-regulates activity
|
MAPK14 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253600 |
|
|
|
|
| pmid |
sentence |
| 17151142 |
[...] TNF-alpha is critical for p38 activation during the early stages of myoblast differentiation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253602 |
|
|
|
|
| pmid |
sentence |
| 20887952 |
These results indicate that TNF-a-activated p38 pathway negatively controls the expansion of PAX7-positive SCs |
|
| Publications: |
2 |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
MAPT |
0.317 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166611 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
A large number of cytosolic proteins can be phosphorylated by p38 mapks, including phospholipase a2, the microtubule-associated protein tau, nhe-1, cyclin d1, cdk inhibitors, bcl2 family proteins, growth factor receptors or keratins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates
|
PPARG |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210090 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12589053 |
Specific inhibitors for p38 kinase inhibited bmp2-induced adipocytic differentiation and transcriptional activation of ppargamma, whereas overexpression of smad6 had no effect on transcriptional activity of ppargamma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SB 203580 | down-regulates activity
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258279 |
|
|
in vitro |
|
| pmid |
sentence |
| 22037378 |
Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | FLT3-ITD signaling |
| + |
TNFRSF1A | up-regulates
|
MAPK14 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226637 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11672426 |
Conversely, only activation of the TNFR1 could stimulate mitogen-activated protein kinase (MAPK) or p38 MAPK activities in a time-dependent manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235370 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 17151142 |
These results indicate that TNF-alpha regulates myogenesis and muscle regeneration as a key activator of p38. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling |
| + |
MAPK14 | down-regulates
|
EIF4EBP1 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113566 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11777913 |
Phosphorylation of 4e-bp1 is mediated by the p38/msk1 pathway in response to uvb irradiation. In the present study we demonstrated that uvb induced 4e-bp1 phosphorylation at multiple sites, thr-36, thr-45, ser-64, and thr-69, leading to dissociation of 4e-bp1 from eif-4e. Uvb-induced phosphorylation of 4e-bp1 was blocked by p38 kinase inhibitors, pd169316 and sb202190, and msk1 inhibitor, h89, but not by mitogen-activated protein kinase kinase inhibitors, pd98059 or u0126. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | down-regulates
|
MAPK14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244665 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 11842088 |
In addition, immunoblot and immunostaining analysis revealed that phosphorylation of erk was increased by treatment with sb203580;whereas pd98059 increased the phosphorylation of p38, which implies a seesaw-like balance between erk and p38 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Toll like receptors |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
SP7 |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255791 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20682789 |
We therefore propose that Osterix binds to Sp1 sequences on target gene promoters and that its phosphorylation by p38 enhances recruitment of coactivators to form transcriptionally active complexes |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK14 | up-regulates
phosphorylation
|
SIAH2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149890 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17003045 |
We show that siah2 is subject to phosphorylation by p38 mapk, which increases siah2-mediated degradation of phd3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP2K1 | down-regulates
|
MAPK14 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178636 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18481201 |
Pd98059, a specific inhibitor of mek in addition, immunoblot and immunostaining analysis revealed that phosphorylation of erk was increased by treatment with sb203580;whereas pd98059 increased the phosphorylation of p38, which implies a seesaw-like balance between erk and p38 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
|
MAPK14 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180308 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16;ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha;ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN7 | down-regulates
binding
|
MAPK14 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182525 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 19047375 |
Thus, beta(2)ar stimulation on a b cell phosphorylates and inactivates heptp in a gs/camp/pka-dependent manner to release bound p38 mapk, making more available for phosphorylation and subsequent ige regulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255745 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15824134 |
Inhibition of p38 / MAPKs (a) promotes exit from the cell cycle, (b) prevents differentiation, and (c) insulates the cell from most external stimuli allowing the satellite cell to maintain a quiescent state. Activation of satellite cells and p38 / MAPKs occurs concomitantly, providing further support that these MAPKs function as a molecular switch for satellite cell activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | FLT3-ITD signaling, Glucocorticoid receptor Signaling, P38 Signaling, TNF-alpha Signaling, TGF-beta Signaling |
| + |
DUSP4 | down-regulates
dephosphorylation
|
MAPK14 |
0.666 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147958 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16849326 |
This result suggests that dusp4 represses gluconeogenesis through dephosphorylation of p38 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP5 | down-regulates
dephosphorylation
|
MAPK14 |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
The activity of mapks can be also regulated by a family of dusps, which dephosphorylates bot phosphotyrosine and phopsphothreonine residues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MAPKAPK3 |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235451 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 11157753 |
These results, taken together, suggest the importance of the docking interaction in the efficient phosphorylation and activation of 3pk by p38. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK14 | down-regulates activity
|
MEK1/2 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263511 |
|
|
Homo sapiens |
Skin Fibroblast |
| pmid |
sentence |
| 12839928 |
Activation of p38 MAPK is required for arsenite-induced apoptosis and MEK1,2 dephosphorylation in human skin fibroblasts. Our data suggest the presence of a continuous negative feedback from p38α and p38β to MEK1,2 as simultaneous inhibition of p38α and p38β isoforms in normal quiescent cells resulted in accumulation of phosphorylated MEK1,2 (Fig. 2A) ⇓ . This negative regulation of MEK1,2 in normal cells could be considered a means to control MEK1,2-mediated proliferation and expression of transformation-related genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Toll like receptors |
| + |
4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide | down-regulates
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-128864 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15362850 |
In steady-state kinetics experiments, cmpd1 was observed to prevent the p38alpha-dependent phosphorylation (k(i)(app) = 330 nm) of the splice variant of mitogen-activated protein kinase-activated protein kinase 2 (mk2a) that contains a docking domain for p38alpha and p38beta |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
RUNX2 |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255777 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20551513 |
Mechanistic analysis revealed that the TAK1–MKK3/6–p38 MAPK axis phosphorylated Runx2, promoting its association with the coactivator CREB-binding protein (CBP), which was required to regulate osteoblast genetic programs. These findings reveal an in vivo function for p38β and establish that MAPK signaling is essential for bone formation in vivo. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | TGF-beta Signaling |
| + |
MAPK14 | up-regulates quantity by expression
transcriptional regulation
|
JUNB |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10330170 |
Moreover, in addition to jnk, erk5, p38alpha, and p38gamma were found to stimulate the c-jun promoter by acting on distinct responsive elements. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates quantity by expression
transcriptional regulation
|
HBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251837 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20162623 |
Our results demonstrate that activin A induced Hb synthesis and promoter activation of the specific erythroid gene, ζ-globin, through p38α and p38β isoforms and their activator, MKK6 (mitogen-activated protein kinase kinase 6). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
doramapimod | down-regulates activity
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258208 |
|
|
in vitro |
|
| pmid |
sentence |
| 22037378 |
Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAPK14 | up-regulates
|
HIF1A |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149887 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17003045 |
The ring finger ubiquitin ligase siah2 controls the stability of various substrates involved in stress and hypoxia responses, including the phd3, which controls the stability of hif-1alpha. In the present study we determined the role of siah2 phosphorylation in the regulation of its activity toward phd3. We show that siah2 is subject to phosphorylation by p38 mapk, which increases siah2-mediated degradation of phd3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR1A | up-regulates activity
|
MAPK14 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255785 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19620713 |
The expression of CA-BMPr1A and CA-BMPr1B mRNA was confirmed by RT-PCR using appropriate primers to distinguish expression of the constitutively active receptors from endogenous BMP receptors; specific antibodies for these receptors were not available. However, the functional effects of their expression, i.e., phosphorylation of Smad1/5/8 and p38 MAPK, verify overexpression of the constitutively active receptors (Fig. 3B). Thus, their overexpression provoked a substantial rise in the phosphorylation of Smad1/5/8 and p38 MAPK, known downstream phosphorylated intermediates in the BMP signaling pathway (Fig. 3B) (16, 17). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
DUSP8 | down-regulates
dephosphorylation
|
MAPK14 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199695 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23159405 |
M3/6 (dusp8) is a dual-specificity phosphatase implicated in the dephosphorylation and inactivation of jnk and, to a lesser extent, p38 mapk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
CDKN1C |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22820251 |
G1-s control by p38/hog1 sapks upon osmostress. Upon osmostress, activated p38 and hog1 sapks phosphorylate the s/cdk inhibitor p57 or sic1 respectively at one single residue. In mammalian cells (left panel), p57 phosphorylation on thr143 leads to an increase of the affinity of p57 towards the cyclin a/cdk2 complex leading to a g1 arrest. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)-3-pyridinecarboxamide | down-regulates
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-207681 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20162623 |
Our results demonstrate that activin A induced Hb synthesis and promoter activation of the specific erythroid gene, ζ-globin, through p38α and p38β isoforms and their activator, MKK6 (mitogen-activated protein kinase kinase 6). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1A | down-regulates activity
dephosphorylation
|
MAPK14 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9707433 |
Moreover, when expressed in mammalian cells, pp2ca inhibited the activation of the p38 and jnk cascades induced by environmental stresses. Both in vivo and in vitro observations indicated that pp2ca dephosphorylated and inactivated mapkks (mkk6 and sek1) and a mapk (p38) in the stress-responsive mapk cascades. Furthermore, a direct interaction of pp2ca and p38 was demonstrated by a co-immunoprecipitation assay |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
GATA2 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25056917 |
P38_ increases gata_2 activity at endogenous target genes by inducing gata_2 multi_site phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
VX-745 | down-regulates activity
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258310 |
|
|
in vitro |
|
| pmid |
sentence |
| 22037378 |
Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
NR3C1 | down-regulates activity
|
MAPK14 |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251675 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11742987 |
The MAP kinase p38 is also a target for negative regulation by glucocorticoids |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
MAP3K4 | up-regulates activity
|
MAPK14 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170534 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21152872 |
We found that mekk1/mekk4 as opposed to ask1, are responsible for trail-induced c-jun nh2-terminal kinase (jnk) or p38 activation, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
SPAG9 | up-regulates activity
binding
|
MAPK14 |
0.562 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149979 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 17074887 |
Cdo, jlp, and p38alpha/beta form complexes in differentiating myoblasts, and cdo and jlp cooperate to enhance levels of active p38alpha/beta in transfectants. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
TNFRSF1B | up-regulates activity
|
MAPK14 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253603 |
|
|
|
|
| pmid |
sentence |
| 20887952 |
These results indicate that TNF-a-activated p38 pathway negatively controls the expansion of PAX7-positive SCs |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253601 |
|
|
|
|
| pmid |
sentence |
| 17151142 |
[...] TNF-alpha is critical for p38 activation during the early stages of myoblast differentiation |
|
| Publications: |
2 |
| + |
MAPK14 | up-regulates
|
M2_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255447 |
|
|
|
|
| pmid |
sentence |
| 22933625 |
The IL-10-mediated shift in macrophage phenotype in injured muscle may be amplified by activation of mitogen-activated protein kinase (MAPK), especially p38 MAPK, through signaling that is antagonized by MAPK phosphatase-1 (MKP-1). |
|
| Publications: |
1 |
| + |
GSK3B | down-regulates
binding
|
MAPK14 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157544 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17726008 |
Here we show that similar to the interaction with traf4 and axin, the kinase domain of mekk4 interacts with the multifunctional serine/threonine kinase gsk3beta. Gsk3beta binding to mekk4 blocks mekk4 dimerization that is required for mekk4 activation, effectively inhibiting mekk4 stimulation of the jnk and p38 mapk pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
PPM1D | down-regulates activity
dephosphorylation
|
MAPK14 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187770 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19713933 |
In addition, wip1 can dephosphorylate atm, as well as other components of the dna damage checkpoint, such as p38. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84793 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11101524 |
Wip1 selectively inactivates p38 by specific dephosphorylation of its conserved threonine residue |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide | down-regulates activity
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262223 |
|
|
in vitro |
|
| pmid |
sentence |
| 16162000 |
A novel structural class of 4-phenyl-5-pyridyl-1,3-thiazoles was optimized as inhibitors of p38 MAP kinase and the proinflammatory cytokine TNF-α. it only significantly inhibited p38α (IC50 = 7.1 nM) and p38β (IC50 = 200 nM) in a concentration-dependent manner and was approximately 28 times more selective for p38α over p38β. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SB 203580 | down-regulates
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111064 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11606413 |
Pretreatment of hela cells with sb 203580, a pyridinyl imidazole compound that specifically inhibits p38 mitogen-activated protein kinase (mapk). It has previously been established that sb 203580 acts primarily to block the catalytic activity of p38 mapk. However, it has been suggested that in cells, the compounds could also inhibit p38 mapk activation by virtue of their ability to bind to the inactive enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75389 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10702313 |
Pretreatment of hela cells with sb 203580, a pyridinyl imidazole compound that specifically inhibits p38 mitogen-activated protein kinase (mapk). It has previously been established that sb 203580 acts primarily to block the catalytic activity of p38 mapk. However, it has been suggested that in cells, the compounds could also inhibit p38 mapk activation by virtue of their ability to bind to the inactive enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126055 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15208625 |
Pretreatment of hela cells with sb 203580, a pyridinyl imidazole compound that specifically inhibits p38 mitogen-activated protein kinase (mapk). It has previously been established that sb 203580 acts primarily to block the catalytic activity of p38 mapk. However, it has been suggested that in cells, the compounds could also inhibit p38 mapk activation by virtue of their ability to bind to the inactive enzyme. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-71024 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10512765 |
Pretreatment of hela cells with sb 203580, a pyridinyl imidazole compound that specifically inhibits p38 mitogen-activated protein kinase (mapk). It has previously been established that sb 203580 acts primarily to block the catalytic activity of p38 mapk. However, it has been suggested that in cells, the compounds could also inhibit p38 mapk activation by virtue of their ability to bind to the inactive enzyme. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
PTPN5 | up-regulates
binding
|
MAPK14 |
0.49 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-194829 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 23932588 |
First [] step prevents upstream activating kinases from promiscuously binding and activating p38a. Second, by blocking access to the mapk insert pocket, through the stepcat interaction, step can prevent the binding of allosteric signaling molecules that induce autoactivation of p38a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
|
MYOD1 |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129702 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15466486 |
Here, we show that p38 activity facilitates myod and mef2 binding at a subset of late-activated promoters, and the binding of mef2d recruits pol ii. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis |
| + |
MAPK14 | up-regulates
phosphorylation
|
CCND1 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166594 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
A large number of cytosolic proteins can be phosphorylated by p38 mapks, including phospholipase a2, the microtubule-associated protein tau, nhe-1, cyclin d1, cdk inhibitors, bcl2 family proteins, growth factor receptors or keratins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP2 | down-regulates
dephosphorylation
|
MAPK14 |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-40918 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8626452 |
We show that the in vivo substrate specificities of individual phosphatases are unique. Pac1, mkp-2, and mkp-1 recognize erk and p38, erk and jnk, and erk, p38, and jnk, respectively |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TAB1 | up-regulates activity
binding
|
MAPK14 |
0.825 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143576 |
|
|
Rattus norvegicus |
Cardiomyocyte Cell Line |
| pmid |
sentence |
| 16407200 |
In contrast to MKK3-induced p38 kinase downstream effects, TAB-1-induced p38 kinase activation does not induce expression of pro-inflammatory genes, cardiac marker gene expression, or changes in cellular morphology. Rather, TAB-1 binds to p38 and prevents p38 nuclear localization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114843 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11847341 |
Here, we report an unexpected activation mechanism for p38alpha MAPK that does not involve the prototypic kinase cascade. Rather it depends on interaction of p38alpha with TAB1 [transforming growth factor-beta-activated protein kinase 1 (TAK1)-binding protein 1] leading to autophosphorylation and activation of p38alpha. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
EZH2 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176548 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
P38 can phosphorylate the histone-lysine n-methyltransferase ezh2, the catalytic subunit of the polycomb repressive complex 2 (prc2), with phosphorylation of ezh2 necessary for prc2s association with the transcriptional repressor yy1 and subsequent chromatin remodelling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
PTPN1 | down-regulates activity
dephosphorylation
|
MAPK14 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277167 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24590766 |
Here, we show that PTP1B regulates CD40 and BAFF-R signaling and dephosphorylates the mitogen-activated protein kinase p38.|Specifically, PTP1B counteracts p38 mitogen-activated protein kinase activation by directly dephosphorylating Tyr182 of this kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRIM27 | up-regulates
|
MAPK14 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12807881 |
We found rfp-mediated activation of both exogenous and endogenous forms of the other stress-activated mapk, p38. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
TNF | up-regulates activity
|
MAPK14 |
0.648 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16813528 |
These observations suggest that tnf-alpha activates p38 map kinase during the inflammatory response at the injured growth plate, and tnf-alpha-p38 signaling seems to be required for marrow mesenchymal cell proliferation and migration at the growth plate injury site and in cell culture. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling |
| + |
MAPK14 | up-regulates activity
binding
|
DUSP1 |
0.806 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83752 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11062068 |
Here we have shown that mkp-1 associates directly with p38 map kinase both in vivo and in vitro, and that this interaction enhances the catalytic activity of mkp-1. The point mutation asp-316-->asn in the c-terminus of p38, analogous to the erk2 (extracellular-signal-regulated kinase 2) sevenmaker mutation, dramatically decreases its binding to mkp-1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling and Myogenesis, P38 Signaling |
| + |
TNFRSF17 | up-regulates
|
MAPK14 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79504 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10903733 |
Overexpression of bcma activates the p38 mapk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GADD45A | down-regulates
binding
|
MAPK14 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134333 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 15735649 |
Both phosphorylation of p38 ty323 and the activity of this phosphorylated species are inhibited by binding gadd45alpha, thus preventing these low-treshold signals from activating p38 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166584 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Gadd45alfa appears to act as an endogenous inhibitor of the alternative p38alfa-activation pathway in t-cell, by binding to p38alfa and preventing tyr323 phosphorilation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates
phosphorylation
|
MAP3K11 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166605 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Jnk and p38 mapk activation have antagonistic effects in many cases. From a mechanicistic point of view, the p38 mapk pathway can negatively regulate jnk activity at the level of map3ks, either by phosphorylating mlk3 or the tak1 regulatory subunit tab2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
EEA1 |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140085 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16138080 |
We found that p38alpha can phosphorylate the rab5 effectors eea1 and rabenosyn-5 on thr-1392 and ser-215, respectively, and these phosphorylation events regulate the recruitment of eea1 and rabenosyn-5 to membranes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
MEF2D |
0.613 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159331 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18026121 |
Targeting of ash2l to specific genes is mediated by the transcriptional regulator mef2d. Furthermore, this interaction is modulated during differentiation through activation of the p38 mapk signaling pathway via phosphorylation of mef2d. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176554 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Through phosphorylation of mef2d, p38 recruits an ash2l-containing complex to myogenic loci during differentiation, which results in the marking of these genes for expression. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | P38 Signaling and Myogenesis |
| + |
DUSP9 | down-regulates
dephosphorylation
|
MAPK14 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87150 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11988087 |
These properties define the ability of this enzyme to dephosphorylate and inactivate erk1/2 and p38a, but not jnk (c-jun n-terminal kinase) in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
STK39 | up-regulates
binding
|
MAPK14 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118848 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14563843 |
Spak, a ste20/sps1-related kinase that activates the p38 pathway. p38, one of the three major mapks, can be coimmunoprecipitated with spak and with nkcc1 in an activity-dependent manner. The amount of p38 coimmunoprecipitated with the kinase and the cotransporter significantly decreases upon cellular stress, |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81541 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10980603 |
Spak, a ste20/sps1-related kinase that activates the p38 pathway. p38, one of the three major mapks, can be coimmunoprecipitated with spak and with nkcc1 in an activity-dependent manner. The amount of p38 coimmunoprecipitated with the kinase and the cotransporter significantly decreases upon cellular stress, |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
FGF2 | up-regulates
|
MAPK14 |
0.392 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168992 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20974802 |
We show that several proline-directed mitogen-activated protein kinases (mapks), such as p38, erk1/2, and jnk1 are sufficient and required for the phosphorylation of ppps/tp motifs of lrp6. External stimuli, which control the activity of mapks, such as phorbol esters and fibroblast growth factor 2 (fgf2) control the choice of the lrp6-ppps/tp kinase and regulate the amplitude of lrp6 phosphorylation and wnt/beta-catenin-dependent transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113649 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11781339 |
In these collagen gel cultures, p38 activation was induced more potently by fgf-2 treatment compared with that in proliferating cultures |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
3a | up-regulates activity
|
MAPK14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260444 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 18632968 |
Severe Acute Respiratory Syndrome Coronavirus 3a Protein Activates the Mitochondrial Death Pathway Through p38 MAP Kinase Activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
SMARCD3 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176557 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
P38 phosphorylates the baf60 subunit of the swi-snf chromatin remodelling complex, and p38 recruits this complex to differentiation-specific loci. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAPK14 | up-regulates activity
|
AKT |
0.634 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244465 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12181443 |
We show [] that the kinase activity and s473 phosphorylation of akt induced by lpa and s1p requires both mitogen-activated protein (map) kinase kinase (mek) and p38 map kinase. [] among different stimuli tested, platelet-derived growth factor stimulates s473 phosphorylation of akt in a mek- and p38-dependent manner. However, epidermal growth factor, thrombin, and endothelin-1?stimulated Akt s473 phosphorylation require p38 but not mek. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
CDON | up-regulates activity
binding
|
MAPK14 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179867 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 18678706 |
During myoblast differentiation, the promyogenic cell surface receptor cdo binds to the p38alpha/beta pathway scaffold protein jlp and, via jlp, p38alpha/beta itself |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
Polycomb repressive complex 2 |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253599 |
|
|
Cricetulus griseus |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 20887952 |
The chromatin redistribution of PRC2 in differentiating SCs is regulated by the p38a kinase, which promotes the formation of a complex containing p38a, EZH2, and YY1, via direct phosphorylation of EZH2. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
MAPK1 | down-regulates
|
MAPK14 |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114771 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 11842088 |
In addition, immunoblot and immunostaining analysis revealed that phosphorylation of erk was increased by treatment with sb203580;whereas pd98059 increased the phosphorylation of p38, which implies a seesaw-like balance between erk and p38 phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178639 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18481201 |
In addition, immunoblot and immunostaining analysis revealed that phosphorylation of erk was increased by treatment with sb203580;whereas pd98059 increased the phosphorylation of p38, which implies a seesaw-like balance between erk and p38 phosphorylation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
MKNK2 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48349 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9155017 |
Erk and p38 phosphorylate mnk1 and mnk2, which stimulates their in vitro kinase activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 |
phosphorylation
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265338 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10806218 |
More importantly, incubation of active erk2 or p38 kinase with h3 protein resulted in phosphorylation of h3 at serine 10 in vitro. These results suggest that erk and p38 kinase are at least two important mediators of phosphorylation of h3 at serine 10. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP2 | up-regulates
|
MAPK14 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-98369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12589053 |
Specific inhibitors for p38 kinase inhibited bmp2-induced adipocytic differentiation and transcriptional activation of ppargamma, whereas overexpression of smad6 had no effect on transcriptional activity of ppargamma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates
|
MAPK10 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166608 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Jnk and p38 mapk activation have antagonistic effects in many cases. Froma a mechanicistic point of view, the p38 mapk pathway can negatively regulate jnk activity at the level of map3ks, either by phosphorylating mlk3 or the tak1 regulatory subunit tab1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 |
phosphorylation
|
H3-3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77224 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10806218 |
More importantly, incubation of active erk2 or p38 kinase with h3 protein resulted in phosphorylation of h3 at serine 10 in vitro. These results suggest that erk and p38 kinase are at least two important mediators of phosphorylation of h3 at serine 10. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates
phosphorylation
|
MAX |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7479834 |
Mxi2 phosphorylates max both in vitro and in vivo. Phosphorylation by mxi2 may affect the ability of max to oligomerize with itself and its partners, bind dna, or regulate gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates activity
|
AKT2 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166591 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
On the other hand, p38 alfa may negatively modulate akt activity, indipendently of pi3k by regulating the interaction between caveolin 1 and pp2a through a mechanism dependent on cell attachment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MAPK14 | down-regulates activity
phosphorylation
|
ZFP36 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253596 |
|
|
Cricetulus griseus |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 25815583 |
TTP appears to be a p38α/β MAPK target and pretreating skeletal muscle with a p38α/β MAPK inhibitor reduces TTP phosphorylation. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
MAPK14 | down-regulates
phosphorylation
|
EGFR |
0.505 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149089 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16932740 |
In conclusion, the use of pharmacological agents suggests that p38 mapk is the enzyme involved in egfr phosphorylation, as well as internalization, following exposure of cells to various stress-inducing conditions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PH 797804 | down-regulates
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-206079 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
GATA2 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259946 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25056917 |
P38α promotes multi‐site GATA‐2 phosphorylation, increasing its localization in nuclear foci enriched in an active form of RNA polymerase II and its capacity to regulate endogenous target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | HaematopoiesisTranscriptionalControl |
| + |
MAPK14 | up-regulates
phosphorylation
|
SUZ12/EZH2 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217676 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
P38 can phosphorylate the histone-lysine n-methyltransferase ezh2, the catalytic subunit of the polycomb repressive complex 2 (prc2), with phosphorylation of ezh2 necessary for prc2s association with the transcriptional repressor yy1 and subsequent chromatin remodelling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDC42 | up-regulates activity
|
MAPK14 |
0.605 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176501 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
Precisely how this complex results in p38 activation is not known, but complex recruitment of the gtpase cdc42 is required for p38 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
DUSP16 | down-regulates
dephosphorylation
|
MAPK14 |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108233 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11359773 |
Mkp-7 binds to and inactivates p38 mapk and jnk/sapk, but not erk inhibited by dual specificity phosphatases, such as dusp1, dusp10, and dusp16(uniprot) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
doramapimod | down-regulates
chemical inhibition
|
MAPK14 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190332 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
CFLAR |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19597496 |
Here we demonstrate that m. tuberculosis?induced Tnf triggered reactive oxygen species?dependent Activation of ask1 and the tyrosine kinase c-abl (a000161) in mouse macrophages and that flips was phosphorylated on tyr211 and ser4 by c-abl and p38, respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDON/SPAG9 | up-regulates activity
binding
|
MAPK14 |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272542 |
|
|
Homo sapiens |
Myoblast |
| pmid |
sentence |
| 17074887 |
One way this occurs is via the interaction of JLP with the Cdo cytoplasmic tail. JLP is, in turn, bound to p38α/β. This interaction facilitates p38 activation during differentiation and is important for Cdo's effects in myogenesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates quantity by repression
transcriptional regulation
|
CCND1 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43096 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8702807 |
This result suggests that the p38mapk cascade could be involved in the negative regulation of cyclin d1 transcription and thus antagonize the mitogen-dependent stimulation of cyclin d1 transcription mediated, at least in part, by the p42/p44mapk cascade. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TLR4 | up-regulates activity
phosphorylation
|
MAPK14 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263652 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28137827 |
Binding of S100A9 to TLR4 stimulates the phosphorylation of JNK, ERK1/2, and p38 MAPK, which leads to the activation of c-Jun, CREB, and NF-κB. Activation of neutrophils by S100A9 also proceeds via p38 MAPK, JNK, and ERK1/2 phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
RAC1 | up-regulates
|
MAPK14 |
0.538 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174602 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21712438 |
Hypertonicity activates p38 via a rac1-osm-mekk3-mkk3-p38 pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
MAPK14
- 
- 