Summary

Name MAPK14
Full Name Mitogen-activated protein kinase 14
Synonyms MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a | CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Primary ID Q16539
Links - -
Type protein
Relations 279
Pathways HaematopoiesisTranscriptionalControl, FAP: BMP, FAP: TGF beta, FLT3-ITD signaling, Glucocorticoid receptor Signaling, Macrophage: IL10, NOTCH Signaling and Myogenesis, Osteoblast: BMP, Osteoblast: TGF beta, P38 Signaling, P38 Signaling and Myogenesis, Satellite: NOTCH, Satellite: TNFA, TNF-alpha Signaling, TGF-beta Signaling, Toll like receptors
Inhibitors SB 203580; VX-745; 6-(N-carbamoyl-2,6-difluoroanilino)-2-(2,4-difluorophenyl)-3-pyridinecarboxamide; 4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide; doramapimod; PH 797804; N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide; SB-202190
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation H3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PIAS2 0.321
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.608
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.457
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation TCF3 0.452
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.758
Publications: 6 Organism: Homo Sapiens,
Pathways:FLT3-ITD signaling, P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation TP53 0.758
Publications: 4 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, P38 Signaling
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation TP53 0.758
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, P38 Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CASP3 0.762
Publications: 1 Organism: Homo Sapiens
Pathways:TNF-alpha Signaling
+ up-regulates img/direct-activation.png phosphorylation BAZ1B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PAK6 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NFATC4 0.417
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.604
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA4 0.591
Publications: 6 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMAD3 0.551
Publications: 3 Organism: Homo Sapiens, Rattus Norvegicus
Pathways:TGF-beta Signaling
+ up-regulates img/direct-activation.png phosphorylation NR3C1 0.484
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png phosphorylation RBSN 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDC25C 0.454
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PPARGC1A 0.567
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates activity img/direct-activation.png phosphorylation MAPKAPK2 0.767
Publications: 6 Organism: Homo Sapiens, In Vitro
Pathways:FLT3-ITD signaling, P38 Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CDX2 0.424
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation F3 0.292
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PIP4K2B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DLX5 0.292
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.566
Publications: 1 Organism: Homo Sapiens
Pathways:TNF-alpha Signaling
+ up-regulates img/direct-activation.png phosphorylation ELK3 0.392
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.598
Publications: 4 Organism: Homo Sapiens,
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.509
Publications: 4 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates activity img/direct-activation.png phosphorylation MEF2C 0.682
Publications: 5 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation GSK3B 0.295
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.343
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation HBP1 0.403
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MEF2A 0.646
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation TAB1 0.812
Publications: 3 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/indirect-activation.png phosphorylation AKT2 0.411
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation PLA2G4A 0.651
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NCOA3 0.507
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation USP21 0.254
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.52
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1 0.446
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TWIST1 0.27
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BCL2L11 0.321
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png phosphorylation FOXO 0.504
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation FOXO3 0.504
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT4 0.581
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SLC9A1 0.554
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.594
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.703
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation KRT8 0.574
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DDIT3 0.592
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation JUNB 0.494
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EPS15 0.357
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PXN 0.332
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2 0.344
Publications: 2 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation ATF2 0.781
Publications: 2 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation PTPN7 0.589
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ZNHIT1 0.324
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ELAVL1 0.539
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAPK14 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EEA1 0.47
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation JDP2 0.395
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation USF1 0.526
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation TP53BP1 0.283
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.721
Publications: 5 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling, TGF-beta Signaling, Toll like receptors
+ up-regulates img/direct-activation.png phosphorylation MAPK14 0.342
Publications: 8 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.74
Publications: 5 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TGF-beta Signaling, Toll like receptors
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.2
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.573
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling, TGF-beta Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAPKAPK5 0.624
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MKNK1 0.664
Publications: 2 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation MKNK1 0.664
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MEF2A 0.646
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation MEF2A 0.646
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation EZH2 0.376
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation ATF2 0.781
Publications: 6 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation KHSRP 0.544
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation ADAM17 0.406
Publications: 1 Organism: Cricetulus Griseus
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ img/unknown.png phosphorylation EWSR1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.589
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK14 0.463
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.454
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/indirect-activation.png MAPK14 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GATA2 0.272
Publications: 1 Organism: Homo Sapiens
Pathways:HaematopoiesisTranscriptionalControl
+ up-regulates img/indirect-activation.png HIF1A 0.308
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MEF2D 0.594
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation RUNX2 0.369
Publications: 1 Organism: Mus Musculus
Pathways:TGF-beta Signaling
+ down-regulates activity img/indirect_inhibition.png MEK1/2 0.663
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Toll like receptors
+ up-regulates img/indirect-activation.png PPARG 0.399
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK14 0.473
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK14 0.616
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ down-regulates activity img/indirect_inhibition.png AKT2 0.411
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/indirect_inhibition.png MAPK14 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling, Toll like receptors
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 4 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.554
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ZFP36 0.363
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/indirect-activation.png MAPK14 0.315
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png AKT 0.635
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/indirect_inhibition.png MAPK14 0.491
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/indirect-activation.png AKT 0.635
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png binding MAPK14 0.49
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK14 0.513
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MAPK14 0.484
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/indirect-activation.png M2_polarization 0.7
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CCND1 0.428
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png MAPK14 0.579
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.528
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:FLT3-ITD signaling, Glucocorticoid receptor Signaling, P38 Signaling, TNF-alpha Signaling, TGF-beta Signaling
+ up-regulates activity img/indirect-activation.png MAPK14 0.301
Publications: 2
+ up-regulates img/direct-activation.png phosphorylation CDKN1C 0.263
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MAPK14 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation MAPK14 0.392
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK14 0.301
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png MAPK10 0.399
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: In Vitro
Pathways:FLT3-ITD signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBA1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation COL1A1 0.274
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPT 0.317
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation CFLAR 0.381
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation Fibrosis 0.7
Publications: 1 Organism: Rattus Norvegicus
Pathways:TGF-beta Signaling
+ up-regulates img/direct-activation.png phosphorylation SUZ12/EZH2 0.376
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GATA2 0.272
Publications: 1 Organism: Homo Sapiens
Pathways:HaematopoiesisTranscriptionalControl
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK14 0.376
Publications: 2
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png binding DUSP1 0.795
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling
+ up-regulates img/indirect-activation.png MAPK14 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MAPK14 0.663
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation H3-3A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAPK14 0.812
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation SIAH2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MKNK2 0.431
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MAPK14 0.411
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.795
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.422
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K11 0.309
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK14 0.393
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAPK14 0.451
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAPK14 0.419
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png phosphorylation EZH2 0.376
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding MAPK14 0.436
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png chemical activation MAPK14 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.57
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.681
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK14 0.398
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/indirect-activation.png MAPK14 0.273
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png binding MAPK14 0.295
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.792
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.527
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.658
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation Polycomb repressive complex 2 0.33
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png phosphorylation SP7 0.413
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation MAX 0.613
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAPK14 0.543
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding MAPK14 0.374
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK14 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation JUNB 0.494
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAPK14 0.376
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ up-regulates img/indirect-activation.png MAPK14 0.265
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SMARCD3 0.377
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ img/unknown.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MAPK14 0.285
Publications: 1 Organism: Mus Musculus
Pathways:FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.651
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EEA1 0.47
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPKAPK3 0.71
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding MAPK14 0.479
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MYOD1 0.456
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
Pathways:NOTCH Signaling and Myogenesis, P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.693
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation CCND1 0.428
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK14 0.589
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MAPK14 0.607
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png EIF4EBP1 0.446
Publications: 1 Organism: Homo Sapiens