| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K4 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 7535770 | SIGNOR-27973 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 7535770 | SIGNOR-28059 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 17548358 | SIGNOR-155377 |
| MAP3K6 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-260915 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 8622669 | SIGNOR-40493 |
| MAP2K3 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-40349 |
| MAP2K6 | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-40423 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 17126298 | SIGNOR-150875 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K4 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 7535770 | SIGNOR-27973 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 7535770 | SIGNOR-28059 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 17548358 | SIGNOR-155377 |
| MAP3K6 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-260915 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40493 |
| MAP2K3 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40349 |
| MAP2K6 | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40423 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 17126298 | SIGNOR-150875 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K4 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-27973 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-28059 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-155377 |
| MAP3K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-260915 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-40493 |
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40349 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40423 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-150875 |
