| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K3 | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates activity | 8622669 | SIGNOR-40353 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 8622669 | SIGNOR-40497 |
| MAP3K6 | MAPK14 | Tyr182 | RHTDDEMtGYVATRW | phosphorylation up-regulates activity | 8622669 | SIGNOR-260916 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 7535770 | SIGNOR-28063 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 17126298 | SIGNOR-150879 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 17548358 | SIGNOR-155381 |
| PTPN7 | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | dephosphorylation down-regulates activity | 10206983 | SIGNOR-248485 |
| MAP2K6 | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates activity | 8622669 | SIGNOR-40427 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP2K3 | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40353 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40497 |
| MAP3K6 | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-260916 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 7535770 | SIGNOR-28063 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 17126298 | SIGNOR-150879 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 17548358 | SIGNOR-155381 |
| PTPN7 | dephosphorylation down-regulates ⊣ | MAPK14 PTyr182 | dephosphorylation up-regulates → | MAPK14 | 10206983 | SIGNOR-248485 |
| MAP2K6 | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40427 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP2K3 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40353 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-40497 |
| MAP3K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-260916 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-28063 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-150879 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-155381 |
| PTPN7 | dephosphorylation → down-regulates activity | MAPK14 | SIGNOR-248485 |
| MAP2K6 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-40427 |
