Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CAMK4	HMGB1	–		phosphorylation up-regulates activity	18802105	SIGNOR-278510
CAMK4	HNRNPL	Ser544	GKSERSSsGLLEWES	phosphorylation up-regulates	22570490	SIGNOR-197367
CAMK4	CREB1	Ser119	EILSRRPsYRKILND	phosphorylation up-regulates	17389598	SIGNOR-153940
CAMK4	CREB1	Ser119	EILSRRPsYRKILND	phosphorylation up-regulates activity	12835716	SIGNOR-102722
CAMK4	STMN1	Ser16	KELEKRAsGQAFELI	phosphorylation down-regulates	7925472	SIGNOR-34743
CAMK4	NOS1	Ser852	SYKVRFNsVSSYSDS	phosphorylation down-regulates activity	10400690	SIGNOR-250713
CAMK4	NOTCH1	–		phosphorylation up-regulates quantity by stabilization	23103515	SIGNOR-279596
CAMK4	GSK3B	Ser9	SGRPRTTsFAESCKP	phosphorylation down-regulates activity	32531122	SIGNOR-279142
CAMK4	LIMK1	Thr508	PDRKKRYtVVGNPYW	phosphorylation up-regulates activity	19696021	SIGNOR-280201
CAMK4	HDAC4	–		phosphorylation down-regulates	11062529	SIGNOR-83837
CAMK4	HDAC4	Ser467	RPLGRTQsAPLPQNA	phosphorylation down-regulates activity	11470791	SIGNOR-250711
CAMK4	HDAC4	Ser632	RPLSRAQsSPASATF	phosphorylation down-regulates activity	11470791	SIGNOR-250712
CAMK4	CREBBP	Ser302	PQLASKQsMVNSLPT	phosphorylation up-regulates activity	11970865	SIGNOR-250710
CAMK4	PHB2	Ser91	RARPRKIsSPTGSKD	phosphorylation down-regulates	21689744	SIGNOR-174437
CAMK4	NOVA2	Ser194	EQVHKAVsAIVQKVQ	phosphorylation unknown	32492405	SIGNOR-273519
CAMK4	NOVA2	Ser25	EVVCTKRsNTGEEGE	phosphorylation up-regulates quantity	32492405	SIGNOR-273521
CAMK4	NOVA2	Thr27	VCTKRSNtGEEGEYF	phosphorylation up-regulates quantity	32492405	SIGNOR-273520
CAMK4	HDAC5	Ser259	FPLRKTAsEPNLKVR	phosphorylation down-regulates	11114197	SIGNOR-85106
CAMK4	HDAC5	Ser498	RPLSRTQsSPLPQSP	phosphorylation down-regulates	11114197	SIGNOR-85110
CAMK4	HDAC5	Ser259	FPLRKTAsEPNLKVR	phosphorylation down-regulates	12058061	SIGNOR-236571
CAMK4	HDAC5	Ser498	RPLSRTQsSPLPQSP	phosphorylation down-regulates	12058061	SIGNOR-236575

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CAMK4	phosphorylation up-regulates →	HNRNPL PSer544	phosphorylation up-regulates →	HNRNPL	22570490	SIGNOR-197367
CAMK4	phosphorylation up-regulates →	CREB1 PSer119	phosphorylation up-regulates →	CREB1	17389598	SIGNOR-153940
CAMK4	phosphorylation up-regulates →	CREB1 PSer119	phosphorylation up-regulates →	CREB1	12835716	SIGNOR-102722
CAMK4	phosphorylation up-regulates →	STMN1 PSer16	phosphorylation down-regulates ⊣	STMN1	7925472	SIGNOR-34743
CAMK4	phosphorylation up-regulates →	NOS1 PSer852	phosphorylation down-regulates ⊣	NOS1	10400690	SIGNOR-250713
CAMK4	phosphorylation up-regulates →	GSK3B PSer9	phosphorylation down-regulates ⊣	GSK3B	32531122	SIGNOR-279142
CAMK4	phosphorylation up-regulates →	LIMK1 PThr508	phosphorylation up-regulates →	LIMK1	19696021	SIGNOR-280201
CAMK4	phosphorylation up-regulates →	HDAC4 PSer467	phosphorylation down-regulates ⊣	HDAC4	11470791	SIGNOR-250711
CAMK4	phosphorylation up-regulates →	HDAC4 PSer632	phosphorylation down-regulates ⊣	HDAC4	11470791	SIGNOR-250712
CAMK4	phosphorylation up-regulates →	CREBBP PSer302	phosphorylation up-regulates →	CREBBP	11970865	SIGNOR-250710
CAMK4	phosphorylation up-regulates →	PHB2 PSer91	phosphorylation down-regulates ⊣	PHB2	21689744	SIGNOR-174437
CAMK4	phosphorylation up-regulates →	NOVA2 PSer194	phosphorylation down-regulates ⊣	NOVA2	32492405	SIGNOR-273519
CAMK4	phosphorylation up-regulates →	NOVA2 PSer25	phosphorylation up-regulates →	NOVA2	32492405	SIGNOR-273521
CAMK4	phosphorylation up-regulates →	NOVA2 PThr27	phosphorylation up-regulates →	NOVA2	32492405	SIGNOR-273520
CAMK4	phosphorylation up-regulates →	HDAC5 PSer259	phosphorylation down-regulates ⊣	HDAC5	11114197	SIGNOR-85106
CAMK4	phosphorylation up-regulates →	HDAC5 PSer498	phosphorylation down-regulates ⊣	HDAC5	11114197	SIGNOR-85110
CAMK4	phosphorylation up-regulates →	HDAC5 PSer259	phosphorylation down-regulates ⊣	HDAC5	12058061	SIGNOR-236571
CAMK4	phosphorylation up-regulates →	HDAC5 PSer498	phosphorylation down-regulates ⊣	HDAC5	12058061	SIGNOR-236575

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CAMK4	phosphorylation → up-regulates activity	HMGB1	SIGNOR-278510
CAMK4	phosphorylation → up-regulates	HNRNPL	SIGNOR-197367
CAMK4	phosphorylation → up-regulates	CREB1	SIGNOR-153940
CAMK4	phosphorylation → up-regulates activity	CREB1	SIGNOR-102722
CAMK4	phosphorylation down-regulates	STMN1	SIGNOR-34743
CAMK4	phosphorylation → down-regulates activity	NOS1	SIGNOR-250713
CAMK4	phosphorylation → up-regulates quantity by stabilization	NOTCH1	SIGNOR-279596
CAMK4	phosphorylation → down-regulates activity	GSK3B	SIGNOR-279142
CAMK4	phosphorylation → up-regulates activity	LIMK1	SIGNOR-280201
CAMK4	phosphorylation down-regulates	HDAC4	SIGNOR-83837
CAMK4	phosphorylation → down-regulates activity	HDAC4	SIGNOR-250711
CAMK4	phosphorylation → down-regulates activity	HDAC4	SIGNOR-250712
CAMK4	phosphorylation → up-regulates activity	CREBBP	SIGNOR-250710
CAMK4	phosphorylation down-regulates	PHB2	SIGNOR-174437
CAMK4	phosphorylation → unknown	NOVA2	SIGNOR-273519
CAMK4	phosphorylation → up-regulates quantity	NOVA2	SIGNOR-273521
CAMK4	phosphorylation → up-regulates quantity	NOVA2	SIGNOR-273520
CAMK4	phosphorylation down-regulates	HDAC5	SIGNOR-85106
CAMK4	phosphorylation down-regulates	HDAC5	SIGNOR-85110
CAMK4	phosphorylation down-regulates	HDAC5	SIGNOR-236571
CAMK4	phosphorylation down-regulates	HDAC5	SIGNOR-236575