Summary

Name CAMK4
Full Name Calcium/calmodulin-dependent protein kinase type IV
Synonyms CaMK IV, CaM kinase-GR | CAMK, CAMK-GR, CAMKIV
Primary ID Q16566
Links - -
Type protein
Relations 18
Pathways IGF and Myogenesis
Function Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CREB1 0.37
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STMN1 0.51
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC5 0.35
Publications: 4 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Muscle
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation CREBBP 0.20
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation HDAC4 0.23
Publications: 2
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation HNRNPL 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS1 0.14
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation PHB2 0.52
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation CAMK4 0.84
Publications: 3 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation CAMK4 0.93
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation HDAC4 0.23
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis