Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
AKT	MAP3K11	Ser674	PGRERGEsPTTPPTP	phosphorylation down-regulates	12458207	SIGNOR-96062
GSK3B	MAP3K11	Ser789 View in OncoXplorer	VSAGPRPsPLPSPQP	phosphorylation up-regulates activity	17711861	SIGNOR-276071
AKT1	MAP3K11	Ser674	PGRERGEsPTTPPTP	phosphorylation down-regulates	12458207	SIGNOR-252592
MAP4K1	MAP3K11	Ser281	WHKTTQMsAAGTYAW	phosphorylation up-regulates	11053428	SIGNOR-83415
MAPK14	MAP3K11	–		phosphorylation down-regulates	20626350	SIGNOR-166605
CDK1	MAP3K11	Ser548 View in OncoXplorer	GQAWGRQsPRRLEDS	phosphorylation down-regulates activity	35843311	SIGNOR-277603
GSK3B	MAP3K11	Ser793 View in OncoXplorer	PRPSPLPsPQPAPRR	phosphorylation up-regulates activity	17711861	SIGNOR-276072
GSK3B	MAP3K11	Ser793 View in OncoXplorer	PRPSPLPsPQPAPRR	phosphorylation up-regulates activity	20005250	SIGNOR-279615
MAP4K4	MAP3K11	Thr738	EEEPRGGtVSPPPGT	phosphorylation up-regulates activity	34511598	SIGNOR-277571
MAP3K11	MAP3K11	Thr277	LAREWHKtTQMSAAG	phosphorylation up-regulates	11053428	SIGNOR-83411
CDK2	MAP3K11	Ser770	LISRPRPsPLRSRID	phosphorylation up-regulates activity	35843311	SIGNOR-277604
MAP3K11	MAP3K11	Ser281	WHKTTQMsAAGTYAW	phosphorylation up-regulates	11053428	SIGNOR-83407
GSK3B	MAP3K11	Ser789 View in OncoXplorer	VSAGPRPsPLPSPQP	phosphorylation up-regulates activity	20005250	SIGNOR-279616

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
AKT	phosphorylation up-regulates →	MAP3K11 PSer674	phosphorylation down-regulates ⊣	MAP3K11	12458207	SIGNOR-96062
GSK3B	phosphorylation up-regulates →	MAP3K11 PSer789	phosphorylation up-regulates →	MAP3K11	17711861	SIGNOR-276071
AKT1	phosphorylation up-regulates →	MAP3K11 PSer674	phosphorylation down-regulates ⊣	MAP3K11	12458207	SIGNOR-252592
MAP4K1	phosphorylation up-regulates →	MAP3K11 PSer281	phosphorylation up-regulates →	MAP3K11	11053428	SIGNOR-83415
CDK1	phosphorylation up-regulates →	MAP3K11 PSer548	phosphorylation down-regulates ⊣	MAP3K11	35843311	SIGNOR-277603
GSK3B	phosphorylation up-regulates →	MAP3K11 PSer793	phosphorylation up-regulates →	MAP3K11	17711861	SIGNOR-276072
GSK3B	phosphorylation up-regulates →	MAP3K11 PSer793	phosphorylation up-regulates →	MAP3K11	20005250	SIGNOR-279615
MAP4K4	phosphorylation up-regulates →	MAP3K11 PThr738	phosphorylation up-regulates →	MAP3K11	34511598	SIGNOR-277571
MAP3K11	phosphorylation up-regulates →	MAP3K11 PThr277	phosphorylation up-regulates →	MAP3K11	11053428	SIGNOR-83411
CDK2	phosphorylation up-regulates →	MAP3K11 PSer770	phosphorylation up-regulates →	MAP3K11	35843311	SIGNOR-277604
MAP3K11	phosphorylation up-regulates →	MAP3K11 PSer281	phosphorylation up-regulates →	MAP3K11	11053428	SIGNOR-83407
GSK3B	phosphorylation up-regulates →	MAP3K11 PSer789	phosphorylation up-regulates →	MAP3K11	20005250	SIGNOR-279616

Regulator	Mechanism/Effect	Target	SIGNOR-ID
AKT	phosphorylation down-regulates	MAP3K11	SIGNOR-96062
GSK3B	phosphorylation → up-regulates activity	MAP3K11	SIGNOR-276071
AKT1	phosphorylation down-regulates	MAP3K11	SIGNOR-252592
MAP4K1	phosphorylation → up-regulates	MAP3K11	SIGNOR-83415
MAPK14	phosphorylation down-regulates	MAP3K11	SIGNOR-166605
CDK1	phosphorylation → down-regulates activity	MAP3K11	SIGNOR-277603
GSK3B	phosphorylation → up-regulates activity	MAP3K11	SIGNOR-276072
GSK3B	phosphorylation → up-regulates activity	MAP3K11	SIGNOR-279615
MAP4K4	phosphorylation → up-regulates activity	MAP3K11	SIGNOR-277571
MAP3K11	phosphorylation → up-regulates	MAP3K11	SIGNOR-83411
CDK2	phosphorylation → up-regulates activity	MAP3K11	SIGNOR-277604
MAP3K11	phosphorylation → up-regulates	MAP3K11	SIGNOR-83407
GSK3B	phosphorylation → up-regulates activity	MAP3K11	SIGNOR-279616