+ |
MAP3K11 | up-regulates
phosphorylation
|
PIN1 |
0.266 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-205586 |
Ser138 |
QKPFEDAsFALRTGE |
Homo sapiens |
|
pmid |
sentence |
25519816 |
Here we demonstrate that mixed-lineage kinase 3 (mlk3), a map3k family member, phosphorylates pin1 on a ser138 site to increase its catalytic activity and nuclear translocation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAP3K11 | up-regulates
phosphorylation
|
MAP2K4 |
0.605 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-128420 |
Ser257 |
ISGQLVDsIAKTRDA |
Homo sapiens |
|
pmid |
sentence |
15328343 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-75836 |
Thr261 |
LVDSIAKtRDAGCRP |
Homo sapiens |
|
pmid |
sentence |
10727406 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
MAP3K11 | up-regulates activity
phosphorylation
|
MAP2K4 |
0.605 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-48574 |
Ser257 |
ISGQLVDsIAKTRDA |
Homo sapiens |
COS-1 Cell |
pmid |
sentence |
9003778 |
These data suggest that mlk-3 phosphorylates sek1 directly and that it does so specifically on those residues known to activate sek1 in vivo. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAP4K1 | up-regulates
phosphorylation
|
MAP3K11 |
0.551 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-83415 |
Ser281 |
WHKTTQMsAAGTYAW |
Homo sapiens |
|
pmid |
sentence |
11053428 |
Hpk1 also phosphorylated mlk-3 activation loop in vitro, and ser281 was found to be the major phosphorylation site, indicating that hpk1 also activates mlk-3 via phosphorylation of the kinase activation loop. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAP3K11 | up-regulates
phosphorylation
|
MAP3K11 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-83407 |
Ser281 |
WHKTTQMsAAGTYAW |
Homo sapiens |
|
pmid |
sentence |
11053428 |
These residues within the activation loop are critical for mlk-3 autophosphorylation and activation. In addition, when the thr277 and ser281 residues were mutated to negatively charged glutamic acid to mimic phosphorylated serine/threonine residues, the resulting mutants were fully functional, implying that these two residues may serve as the autophosphorylation sites. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-83411 |
Thr277 |
LAREWHKtTQMSAAG |
Homo sapiens |
|
pmid |
sentence |
11053428 |
These residues within the activation loop are critical for mlk-3 autophosphorylation and activation. In addition, when the thr277 and ser281 residues were mutated to negatively charged glutamic acid to mimic phosphorylated serine/threonine residues, the resulting mutants were fully functional, implying that these two residues may serve as the autophosphorylation sites. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
AKT | down-regulates
phosphorylation
|
MAP3K11 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-96062 |
Ser674 |
PGRERGEsPTTPPTP |
Homo sapiens |
Neuron |
pmid |
sentence |
12458207 |
Negative regulation of mixed lineage kinase 3 by protein kinase b/akt leads to cell survivalthe expression of activated akt1 inhibits mlk3-mediated cell death in a manner dependent on serine 674 phosphorylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
AKT1 | down-regulates
phosphorylation
|
MAP3K11 |
0.411 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252592 |
Ser674 |
PGRERGEsPTTPPTP |
Homo sapiens |
Neuron |
pmid |
sentence |
12458207 |
Negative regulation of mixed lineage kinase 3 by protein kinase b/akt leads to cell survivalthe expression of activated akt1 inhibits mlk3-mediated cell death in a manner dependent on serine 674 phosphorylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAP3K11 | up-regulates activity
phosphorylation
|
MAP2K3 |
0.467 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-45788 |
|
|
Homo sapiens |
COS-1 Cell |
pmid |
sentence |
9003778 |
Immunoprecipitated mlk-3 catalyzed the phosphorylation of sek1 in vitro, and co-transfected mlk-3 induced phosphorylation of sek1 and mkk3 at sites required for activation, suggesting direct regulation of these protein kinases. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SH3RF1 | up-regulates
binding
|
MAP3K11 |
0.522 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-97006 |
|
|
Homo sapiens |
Neuron |
pmid |
sentence |
12514131 |
Taken together, these findings support a model in which apoptotic stimuli or posh overexpression induce direct association between posh and inactive mlks. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAPK8IP3 | up-regulates
binding
|
MAP3K11 |
0.533 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-73909 |
|
|
Homo sapiens |
Neuron |
pmid |
sentence |
10629060 |
These data demonstrate that jip3 interacts with proteins that can form a mapk signaling module, including jnk, mkk7, and mlk3jip3 increases mlk3-stimulated jnk activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Brain |
+ |
MAP3K11 | up-regulates
|
MAPK9 |
0.332 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-59884 |
|
|
Homo sapiens |
|
pmid |
sentence |
9733513 |
This scaffold protein selectively enhanced jnk activation by the mlk signaling pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAP3K11 | up-regulates
|
MAPK8 |
0.607 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-45791 |
|
|
Homo sapiens |
|
pmid |
sentence |
9003778 |
The kinase-inactive mlk-3 failed to activate sapk, demonstraiting that mlk-3 catalytic activity is necessary for the induction of the sapk pathway. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MAPK14 | down-regulates
phosphorylation
|
MAP3K11 |
0.311 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-166605 |
|
|
Homo sapiens |
|
pmid |
sentence |
20626350 |
Jnk and p38 mapk activation have antagonistic effects in many cases. From a mechanicistic point of view, the p38 mapk pathway can negatively regulate jnk activity at the level of map3ks, either by phosphorylating mlk3 or the tak1 regulatory subunit tab2 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |